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Full-Text Articles in Physiology

Bilateral Striatal Necrosis Due To Homoplasmic Mitochondrial 3697g>A Mutation Presents With Incomplete Penetrance And Sex Bias, Shanshan Zhong, Shumeng Wen, Yusen Qiu, Yanyan Yu, Ling Xin, Yang He, Xuguang Gao, Hezhi Fang, Daojun Hong, Jun Zhang Mar 2019

Bilateral Striatal Necrosis Due To Homoplasmic Mitochondrial 3697g>A Mutation Presents With Incomplete Penetrance And Sex Bias, Shanshan Zhong, Shumeng Wen, Yusen Qiu, Yanyan Yu, Ling Xin, Yang He, Xuguang Gao, Hezhi Fang, Daojun Hong, Jun Zhang

Faculty and Student Publications

© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. Background: Heteroplasmic mitochondrial 3697G>A mutation has been associated with leber hereditary optic neuropathy (LHON), mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS), and LHON/MELAS overlap syndrome. However, homoplasmic m.3697G>A mutation was only found in a family with Leigh syndrome, and the phenotype and pathogenicity of this homoplasmic mutation still need to be investigated in new patients. Methods: The clinical interviews were conducted in 12 individuals from a multiple-generation inherited family. Mutations were screened through exome next-generation sequencing and subsequently confirmed by PCR-restriction fragment length …


Sex Comparisons Of Agonist And Antagonist Muscle Electromyographic Parameters During Two Different Submaximal Isometric Fatiguing Tasks, Sunggun Jeon, Xin Ye, William M. Miller Mar 2019

Sex Comparisons Of Agonist And Antagonist Muscle Electromyographic Parameters During Two Different Submaximal Isometric Fatiguing Tasks, Sunggun Jeon, Xin Ye, William M. Miller

Faculty and Student Publications

© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. To examine the task failure time of the force- and position-based submaximal elbow flexion fatiguing tasks for both sexes, twelve men and eight women visited the laboratory for two separate experimental occasions. During the experiment, they pulled against a rigid restraint for the force task and maintained a constant elbow joint angle to support an equivalent inertial load for the position task. For both fatiguing tasks (50% of the isometric strength at the elbow joint angle of 135 …


Association Between Perceived Physical Activity And Cognitive Function In Older Adults, Paul D. Loprinzi, Emily Frith Feb 2019

Association Between Perceived Physical Activity And Cognitive Function In Older Adults, Paul D. Loprinzi, Emily Frith

Faculty and Student Publications

© The Author(s) 2018. There is irrefutable evidence that regular participation in physical activity is favorably associated with numerous positive health outcomes, including cognitive function. Emerging work suggests that perceived physical activity, independent of actual physical activity behavior, is inversely associated with mortality risk. In this study, we evaluate whether perceived physical activity, independent of actual physical activity, is associated with cognitive function, a robust indicator of mortality risk. Data from the cross-sectional 1999–2002 National Health and Nutrition Examination Survey were employed (N = 2352; 60+ years of age). Actual physical activity was assessed via a validated survey. Perceived physical …


Acute Exercise And Mindfulness Meditation On Learning And Memory: Randomized Controlled Intervention, Malina Austin, Paul D. Loprinzi Jan 2019

Acute Exercise And Mindfulness Meditation On Learning And Memory: Randomized Controlled Intervention, Malina Austin, Paul D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). Background: The purpose of this experiment was to evaluate the potential combined effects of acute exercise and mindfulness mediation on episodic memory. Methods: All data collection occurred in the authors’ laboratory (January to May of 2019). In this three-arm, within-subject design, participants (N=20; Mage=21.6 years) completed three counterbalanced laboratory visits, including Exercise Only, Exercise + Meditation and Control. Learning and memory were assessed from a word-list task. A one-factor repeated-measures ANOVA was computed for two memory outcomes, including the learning outcome (average performance across the 6 trials) and the long-term memory recall (10-minute delay). Results: The …