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The Role Of Mmp-2, 9, And 13, In The Regulation Of Skeltal Muscle Hypertrophy Following Functional Overload, Reilly Fitzpatrick
The Role Of Mmp-2, 9, And 13, In The Regulation Of Skeltal Muscle Hypertrophy Following Functional Overload, Reilly Fitzpatrick
Summer Research
PURPOSE: Skeletal muscle is the most abundant tissue in vertebrates that functions primarily to generate locomotion, and exhibits a high degree of structural and functional plasticity that is largely dependent on the level of activity placed on it. Recent studies have shown that a family of enzymes known as matrix metalloproteinases (MMPs) play an important role in regulating this plasticity. Specifically, MMP-2 and MMP-9 degrade components of the extracellular matrix (ECM) surrounding muscle fiber during periods of growth and repair. However, the mechanisms by which these MMPs mediate this response and how each contributes to muscle repair and remodeling remains …