Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (48)
- Toxicology (15)
- Medical Sciences (14)
- Pharmacy and Pharmaceutical Sciences (13)
- Neuroscience and Neurobiology (12)
-
- Diseases (10)
- Physical Sciences and Mathematics (10)
- Environmental Health (9)
- Medicinal Chemistry and Pharmaceutics (9)
- Physiology (9)
- Medical Pharmacology (8)
- Chemicals and Drugs (7)
- Medical Specialties (7)
- Social and Behavioral Sciences (7)
- Biology (6)
- Medical Physiology (6)
- Psychology (6)
- Environmental Sciences (5)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (4)
- Biochemistry, Biophysics, and Structural Biology (4)
- Bioinformatics (4)
- Biomedical Engineering and Bioengineering (4)
- Cell Biology (4)
- Cell and Developmental Biology (4)
- Engineering (4)
- Genetics and Genomics (4)
- Molecular and Cellular Neuroscience (4)
- Institution
-
- Chulalongkorn University (31)
- Virginia Commonwealth University (9)
- University of Kentucky (8)
- University of Dar es Salaam (7)
- University of Louisville (6)
-
- Himmelfarb Health Sciences Library, The George Washington University (5)
- The Texas Medical Center Library (4)
- East Tennessee State University (3)
- Children's Mercy Kansas City (2)
- Grand Valley State University (2)
- Old Dominion University (2)
- Purdue University (2)
- Tennessee State University (2)
- West Virginia University (2)
- Western Kentucky University (2)
- City University of New York (CUNY) (1)
- Duquesne University (1)
- Eastern Michigan University (1)
- Fordham University (1)
- New Jersey Institute of Technology (1)
- Nova Southeastern University (1)
- Rollins College (1)
- Sacred Heart University (1)
- Southern Illinois University Edwardsville (1)
- Touro College and University System (1)
- University of New Mexico (1)
- University of South Florida (1)
- University of Texas at El Paso (1)
- University of the Incarnate Word (1)
- Vocational Training Council (1)
- Keyword
-
- Cancer (5)
- Heavy metals (5)
- Physical Sciences (5)
- Tanzania (4)
- Cisplatin (3)
-
- Aging (2)
- Animals (2)
- Biological Sciences (2)
- CLEFMA (2)
- Cell Culture (2)
- Drug Discovery (2)
- EF-24 (2)
- EGFR (2)
- Heteromer (2)
- Humans (2)
- Pain (2)
- Proteomics (2)
- Tolerance (2)
- 2 (1)
- 2-arylpyrimidine;phosphodiesterase;phosphodiesterase 4B;phosphodiesterase 4D;quantitative structure–activity relationship;S-triazine (1)
- 2-diphenyl-1-picrylhydrazyl;2 (1)
- 2’-azino-bis-(3-ethyl);benzothiazoline-6-sulfonic acid;antioxidant;Lagenaria siceraria;metal chelating;phenolic compounds;phosphomolybdenum (1)
- 5-HT2A (1)
- ABCB1 (1)
- AML (1)
- AMP-activated protein kinase (1)
- Abdominal aortic aneurysm (1)
- Absurdity (1)
- Acetylcholine (1)
- Acute graft vs. host disease (1)
- Publication
-
- The Thai Journal of Pharmaceutical Sciences (31)
- Electronic Theses and Dissertations (9)
- Theses and Dissertations (8)
- Tanzania Journal of Science (7)
- Pharmacology and Physiology Faculty Publications (5)
-
- Dissertations and Theses (Open Access) (4)
- Biology Faculty Research (2)
- Mahurin Honors College Capstone Experience/Thesis Projects (2)
- Manuscripts, Articles, Book Chapters and Other Papers (2)
- Peer Reviewed Articles (2)
- Purdue Journal of Service-Learning and International Engagement (2)
- Theses and Dissertations--Pharmacy (2)
- Appalachian Student Research Forum (1)
- Bioelectrics Publications (1)
- Community & Environmental Health Faculty Publications (1)
- Dissertations (1)
- Doctor of Nursing Practice Projects (1)
- Faculty & Staff Scholarship (1)
- Faculty of Science & Technology (THEi) (1)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (1)
- HPD Articles (1)
- Master of Liberal Studies Theses (1)
- Master's Theses and Doctoral Dissertations (1)
- NYMC Faculty Publications (1)
- Open Access Theses & Dissertations (1)
- Pharmaceutical Sciences ETDs (1)
- Pharmaceutical Sciences Faculty Publications (1)
- Physical Therapy Faculty Publications (1)
- Physiology and Pharmacology Publications (1)
- Publications and Research (1)
- Publication Type
Articles 91 - 104 of 104
Full-Text Articles in Pharmacology
Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong
Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong
The Thai Journal of Pharmaceutical Sciences
Fluocinolone acetonide (FA) buccal solution was prepared for treatment of oral lichen planus using cosolvents and surfactant to enhance FA solubility. Based on solubility power (s), cosolvents enhanced FA solubility in the order; polyethylene glycol 400 .
Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane
Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane
The Thai Journal of Pharmaceutical Sciences
Objective: The aim of the present study was to evaluate the phytochemicals and antioxidant activity of leaf and fruit of wild Bottle gourd. Methods: Successive extraction of dried material was done by soxhlet apparatus and phytochemicals such as total p..
Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung
Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung
The Thai Journal of Pharmaceutical Sciences
Introduction: The history of Dendropanax morbifera LEV., which is indigenous plant in Korea, is quit old and simultaneously, known for locals as remedy of various diseases such as migraine and inflammation. The aim of this study is evaluating the antioxi.
Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara
Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara
The Thai Journal of Pharmaceutical Sciences
The diabetic animal model is very useful for developing functional foods and medicinal drugs. Spontaneously Diabetic Torii (SDT) rat, a non-obese type 2 diabetic model, is one of the hopeful models to play an important role for research and development o.
Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds, Suwijiyo Pramono, Fitriana Hayyu Arifah, Fitrawan Hernuza Pribadi, Agung Endro Nugroho
Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds, Suwijiyo Pramono, Fitriana Hayyu Arifah, Fitrawan Hernuza Pribadi, Agung Endro Nugroho
The Thai Journal of Pharmaceutical Sciences
Paracetamol is a widely used drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Curcuma xanthorrhiza Roxb. is the one of Indonesian medicinal plants that traditionally used to treat liver disorders. The present study .
Insulin Modulates The Strong Reinforcing Effects Of Nicotine And Changes In Insulin Biomarkers In A Rodent Model Of Diabetes, Bryan Cruz
Open Access Theses & Dissertations
This study examined whether the strong reinforcing effects of nicotine and changes in insulin biomarkers observed in diabetic rats are modulated via insulin. A model of diabetes was employed involving administration of streptozotocin (STZ), which produces hypoinsulinemia in rats. The present study included vehicle- or STZ-treated rats that received sham surgery or an insulin pellet. Two-weeks later, the rats were given extended access to intravenous self-administration (IVSA) of saline or nicotine. Concomitant changes in food intake, water responses, and body weight were assessed during 12 days of IVSA. After the last session, plasma levels of insulin, leptin, amylin, and glucagon-like …
Potential Candidates For Treating Deficits Associated With Developmental Ethanol Exposure In A Rodent Model: Solidago Nemoralis & Dimethoxybenzylidene-Anabasine, Logan James Fields
Potential Candidates For Treating Deficits Associated With Developmental Ethanol Exposure In A Rodent Model: Solidago Nemoralis & Dimethoxybenzylidene-Anabasine, Logan James Fields
Theses and Dissertations--Psychology
Prenatal alcohol exposure (Fetal Alcohol Syndrome [FAS] and Fetal Alcohol Spectrum Disorders [FASD’s]) represents the leading preventable cause of intellectual disabilities in the western world, with FASDs estimated to affect approximately 2-5% of live births in the United States at an approximate annual cost of $3.6 billion (CDC, 2015; May et al., 2009). Ethanol (ETOH) exposure during development can lead to a variety of long-term behavioral impairments including problems with executive functioning, motor coordination, spatial learning, attention, and hyperactivity (Jones, 2011; Mattson & Riley, 1998). Much research has been conducted to develop pharmacological and/or environmental interventions to reduce these deficits, …
Role Of C121a In Mglur2 Homodimeric Expression And Function, Jong M. Shin
Role Of C121a In Mglur2 Homodimeric Expression And Function, Jong M. Shin
Theses and Dissertations
The group II metabotropic glutamate receptors are known for their involvement in various psychiatric disorders. The mGluR2 in particular is linked with etiology of schizophrenia especially in the context of crosstalk with 5-HT2A. Thus, the mGluR2 has attracted attentions for its potential therapeutic applications. Despite numerous physiological evidences on the actions of mGluR2, its mechanism is still unclear to this day. It is partially due to the lack of understanding in characteristics of mGluR2 homodimer which is its functionally active form. Therefore, the characterization of dimeric interaction serves as a foundation to advanced understanding of the role of mGluR2. On …
Decoding The Signaling Of The D2r-2ar Heteromer: Relevance To Schizophrenia, Miao Huang
Decoding The Signaling Of The D2r-2ar Heteromer: Relevance To Schizophrenia, Miao Huang
Theses and Dissertations
Schizophrenia is a severe mental disorder affecting ~1% of world population. Two G protein coupled receptors (GPCRs): Gi-coupled dopamine D2 receptor (D2R), and Gq-coupled serotonin 2A receptor (2AR), are targeted by the typical and atypical antipsychotic drugs to treat schizophrenia. These two receptors have been shown to co-localize in brain regions relevant to schizophrenia, including the ventral tegmental area (VTA), striatum, and prefrontal cortex (PFC). Studies in our lab characterized the integrated signaling of the D2R-2AR heteromer and found that both the Gi activity of D2R and the Gq activity of 2AR were potentiated …
Targeting Monoacylglycerol Lipase For The Reversal And Prevention Of Paclitaxel-Induced Allodynia In Mice, Zachary Curry
Targeting Monoacylglycerol Lipase For The Reversal And Prevention Of Paclitaxel-Induced Allodynia In Mice, Zachary Curry
Theses and Dissertations
Chemotherapy-induced peripheral neuropathy (CIPN) is a side-effect of chemotherapy causing pain in the hands and feet. In particular, paclitaxel causes CIPN lasting for years without effective treatment. There is a strong need for analgesics to both treat and prevent CIPN. One system containing multiple targets to treat CIPN is the endogenous cannabinoid system. This system consists of cannabinoid type 1 (CB1) and type 2 (CB2) receptors primarily expressed on presynaptic neurons and cells of the immune system, respectively. Inhibition of monoacylglycerol lipase (MAGL), which hydrolyzes the endogenous cannabinoid 2- arachidonoylglycerol (2-AG), with JZL184 or MJN110 produces …
Metabotropic Glutamate Receptor 2 Activation: Computational Predictions And Experimental Validation, Amr Ellaithy
Metabotropic Glutamate Receptor 2 Activation: Computational Predictions And Experimental Validation, Amr Ellaithy
Theses and Dissertations
G protein-coupled receptors (GPCRs) are the largest family of signaling proteins in animals and represent the largest family of druggable targets in the human genome. Therefore, it is of no surprise that the molecular mechanisms of GPCR activation and signal transduction have attracted close attention for the past few decades. Several stabilizing interactions within the GPCR transmembrane (TM) domain helices regulate receptor activation. An example is a salt bridge between 2 highly conserved amino acids at the bottom of TM3 and TM6 that has been characterized for a large number of GPCRs. Through structural modeling and molecular dynamics (MD) simulations, …
Complexities Of Chronic Opioid Exposure, Maciej Gonek
Complexities Of Chronic Opioid Exposure, Maciej Gonek
Theses and Dissertations
Studies on repeated exposure to opioids have been carried out for decades yet the mechanisms for certain phenomena such as tolerance are still not fully understood. Furthermore, different medications, such as frequently prescribed benzodiazepines, or different disease states, such as HIV, have their own effects and interactions with chronic opioid exposure that are not fully understood. The overall objective of this dissertation was to investigate the complexities of chronic opioid exposure and how different disease states and medications may modulate the effects of chronic opioids. Our findings demonstrate that the administration of diazepam, at doses that are not antinociceptive or …
Delay Discounting And Cannabinoid Enzyme Inhibitors, Devin Andrew Galdieri
Delay Discounting And Cannabinoid Enzyme Inhibitors, Devin Andrew Galdieri
Graduate Theses, Dissertations, and Problem Reports (ETD)
Delay discounting is a measure of impulsive choice that is correlated with maladaptive behavior and psychological disorders. Disruptions to serotonin and dopamine pathways can cause changes in delay discounting, as can lesions to the prefrontal cortex and nucleus accumbens. The endocannabinoid system modulates other neurotransmitter systems, including dopamine and serotonin pathways. Cannabinoid receptors type 1 are found in relatively high concentrations in the nucleus accumbens and the prefrontal cortex. These receptors are activated by endogenous cannabinoids, which are synthesized on demand and broken down by catabolic enzymes. The action of these enzymes can be inhibited by a class of drugs …
Individual Understanding Of The Risks Associated With Polypharmacy, Michelle Patricia Mchenry
Individual Understanding Of The Risks Associated With Polypharmacy, Michelle Patricia Mchenry
Walden Dissertations and Doctoral Studies
With many individuals experiencing multimorbidity, individuals are being prescribed more medications. Although there are benefits to taking medications to manage symptoms and treat disease processes, there are also risks to taking multiple medications. The purpose of this phenomenological study was to explore participants' understanding of the risks associated with practicing polypharmacy. Game theory, credibility theory, and belief bias were the conceptual frameworks used to explain how individuals experienced their care and being prescribed 5 or more medications. Eight participants residing in subsidized housing in a small Midwest city, who were taking 5 or more medications volunteered to take part in …