Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (17)
- Biochemistry, Biophysics, and Structural Biology (5)
- Cell and Developmental Biology (5)
- Physiology (5)
- Toxicology (5)
-
- Biochemistry (4)
- Diseases (4)
- Medical Sciences (4)
- Neuroscience and Neurobiology (4)
- Psychiatry and Psychology (4)
- Social and Behavioral Sciences (4)
- Cancer Biology (3)
- Chemicals and Drugs (3)
- Medicinal Chemistry and Pharmaceutics (3)
- Mental and Social Health (3)
- Molecular and Cellular Neuroscience (3)
- Pharmacy and Pharmaceutical Sciences (3)
- Psychology (3)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (2)
- Behavior and Behavior Mechanisms (2)
- Behavioral Neurobiology (2)
- Biological Psychology (2)
- Cell Biology (2)
- Immunology and Infectious Disease (2)
- Medical Specialties (2)
- Mental Disorders (2)
- Molecular Biology (2)
- Institution
-
- Chulalongkorn University (93)
- University of Kentucky (4)
- Wayne State University (4)
- Aga Khan University (2)
- Old Dominion University (2)
-
- The Texas Medical Center Library (2)
- University at Albany, State University of New York (2)
- University of South Florida (2)
- California Polytechnic State University, San Luis Obispo (1)
- Chapman University (1)
- Connecticut College (1)
- Dartmouth College (1)
- Eastern Illinois University (1)
- Himmelfarb Health Sciences Library, The George Washington University (1)
- Lehigh Valley Health Network (1)
- Linfield University (1)
- Philadelphia College of Osteopathic Medicine (1)
- Southern Adventist University (1)
- St. Mary's University (1)
- Technological University Dublin (1)
- University of Connecticut (1)
- University of Mississippi (1)
- University of Nebraska - Lincoln (1)
- Utah State University (1)
- West Chester University (1)
- Keyword
-
- Zanthoxylum limonella (7)
- Chitosan (5)
- Phyllanthus emblica (5)
- Piperine (3)
- Anti-inflammation (2)
-
- Anti-microbial (2)
- Anti-oxidant (2)
- Antibacterial activity (2)
- Antioxidant (2)
- Caffeine (2)
- Cytochrome P-450 (2)
- Drug delivery (2)
- Effervescent tablet (2)
- Gallic acid (2)
- Glomerular filtration rate (2)
- HPTLC (2)
- Hair conditioner (2)
- Hair tonic (2)
- Impulsivity (2)
- Mice as laboratory animals (2)
- Neurodegeneration (2)
- Obesity (2)
- Oxyresveratrol (2)
- RP-HPLC (2)
- Rice bran oil (2)
- Stability (2)
- Validation (2)
- 2'-N-(2 (1)
- 3 (1)
- 3D culture (1)
- Publication
-
- The Thai Journal of Pharmaceutical Sciences (93)
- Theses and Dissertations--Pharmacy (3)
- Wayne State University Dissertations (3)
- Department of Emergency Medicine (2)
- Dissertations and Theses (Open Access) (2)
-
- Legacy Theses & Dissertations (2009 - 2024) (2)
- USF Tampa Graduate Theses and Dissertations (2)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (1)
- Articles (1)
- Behavioral Neuroscience Honors Papers (1)
- Bioelectrics Publications (1)
- Biology Faculty Publications (1)
- Capstone Research Projects (1)
- Chemistry & Biochemistry Faculty Publications (1)
- Dartmouth Scholarship (1)
- Department of Biological & Biomedical Sciences (1)
- Department of Psychology: Faculty Publications (1)
- Electronic Theses and Dissertations (1)
- Faculty Publications (1)
- Honors Program Theses and Research Projects (1)
- Master's Theses (1)
- PCOM Physician Assistant Studies Student Scholarship (1)
- Pharmacology and Physiology Faculty Publications (1)
- Pharmacy Faculty Articles and Research (1)
- STAR Program Research Presentations (1)
- Theses and Dissertations--Pharmacology and Nutritional Sciences (1)
- Undergraduate Honors Theses (1)
- Wayne State University Theses (1)
- Publication Type
Articles 31 - 60 of 128
Full-Text Articles in Pharmacology
Novel Cis-Restricted Β-Lactam Combretastatin A-4 Analogues Display Anti-Vascular And Anti-Metastatic Properties In Vitro, Seema M. Nathwani, Lisa M. Greene, Linda Hughes, Miriam Carr, Niamh O'Boyle, Susan Mcdonnell, Mary J. Meegan, Daniela M. Zisterer
Novel Cis-Restricted Β-Lactam Combretastatin A-4 Analogues Display Anti-Vascular And Anti-Metastatic Properties In Vitro, Seema M. Nathwani, Lisa M. Greene, Linda Hughes, Miriam Carr, Niamh O'Boyle, Susan Mcdonnell, Mary J. Meegan, Daniela M. Zisterer
Articles
No abstract provided.
Anti-Lipase Activity Of Quercus Infectoria G.Olivier Extract, Sirinan Thubthimthed., Sarunya Laovitthayanggoon, Parkpoom Siriarchavatana, Konlawit Chaithongsri, Chuleratana Banchonglikitkul
Anti-Lipase Activity Of Quercus Infectoria G.Olivier Extract, Sirinan Thubthimthed., Sarunya Laovitthayanggoon, Parkpoom Siriarchavatana, Konlawit Chaithongsri, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Antibacterial Activity Of A-Mangostin From The Pericarp Extract Of Garcinia Mangostana L. Against Drug Resistant Bacteria, Griangsak Eumkeb, Sineewan Phitaktim
Antibacterial Activity Of A-Mangostin From The Pericarp Extract Of Garcinia Mangostana L. Against Drug Resistant Bacteria, Griangsak Eumkeb, Sineewan Phitaktim
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Gene Cloning And Expression Of A Triterpene Synthase From Alangium Lamarckii, Nattaon Tansakul, Pimpimon Tansakul, Wanchai De-Eknamkul
Gene Cloning And Expression Of A Triterpene Synthase From Alangium Lamarckii, Nattaon Tansakul, Pimpimon Tansakul, Wanchai De-Eknamkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Investigation On Phytochemical, Antioxidant And Cytotoxic Properties Of Momordica Cochinchinensis (Gac) Fruit Extracted By Supercritical Fluid Carbon Dioxide (Scf-Co2) Method, Prapaipat Klungsupya., Worawan Tiatragoon, Thanchanok Muangman, Jirawat. Eiamwat, Sarunya Laovitthayanggoon, Jeerayu Thongdo-A, Srisak Trangwacharakul
Investigation On Phytochemical, Antioxidant And Cytotoxic Properties Of Momordica Cochinchinensis (Gac) Fruit Extracted By Supercritical Fluid Carbon Dioxide (Scf-Co2) Method, Prapaipat Klungsupya., Worawan Tiatragoon, Thanchanok Muangman, Jirawat. Eiamwat, Sarunya Laovitthayanggoon, Jeerayu Thongdo-A, Srisak Trangwacharakul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Meloxicam-Loaded Ph Sensitive Polymeric Micelles: Solvents And Entrapment Methods, Thisirak Woraphatphadung, Warayuth Sajomsang, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit
Meloxicam-Loaded Ph Sensitive Polymeric Micelles: Solvents And Entrapment Methods, Thisirak Woraphatphadung, Warayuth Sajomsang, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Stability Evaluation Of A Hair Conditioner Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limon Ella, Sitthiphong Soradech, Buppachart Potduang, Itsara Keeta, Wanlapha Saisin, Suchipha Wannaphatchaiyong, Cholticha Niwaspragrit
Stability Evaluation Of A Hair Conditioner Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limon Ella, Sitthiphong Soradech, Buppachart Potduang, Itsara Keeta, Wanlapha Saisin, Suchipha Wannaphatchaiyong, Cholticha Niwaspragrit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Pharmacokinetic And Bioequivalence Evaluation Of Two Formulations Of Levocetirizine 5 Mg In Healthy Thai Volunteers, Chutima Jantarat, Thitima Keskanokwong
Pharmacokinetic And Bioequivalence Evaluation Of Two Formulations Of Levocetirizine 5 Mg In Healthy Thai Volunteers, Chutima Jantarat, Thitima Keskanokwong
The Thai Journal of Pharmaceutical Sciences
Pharmacokinetics of levoceterizine have been studied, however, obtained information was only from the Western people. เท addition, the license of this drug formulation was expired few years ago. For approval of this new generic drug, the bioequivalen...
Compulsory Licensing Of Chronic Diseases Pharmaceuticals Thailand, Sakda Thanicul, Matthew Lim Braslow
Compulsory Licensing Of Chronic Diseases Pharmaceuticals Thailand, Sakda Thanicul, Matthew Lim Braslow
The Thai Journal of Pharmaceutical Sciences
For pharmaceutical companies, obtaining patent protection for the pharmaceuticals they develop is essential. Patent protection assures that the pharmaceutical company will have a reasonable opportunity to recoup their most likely quite heavy investment in the new drug and allow the company to control the wholesale market price of the drugs. These key intellectual property rights are truly at the heart of the internationally recognized intellectual property regime. For patent right holders in general merchandise, say an innovative paperclip or mousetrap, the absolute right of the patent holder as to the distribution and price is perfectly acceptable. Pharmaceutical patents however, with …
Detection Of Esterase Activity Converting Cytotoxic Renieramycin M To Jorunnamycin A In The Crude Enzyme Of The Nudibranch Jorunna Funebris, Dalad Waropastrakul., Khanit Suwanborirux, Wanchai De-Eknamkul, Taksina Chuanasa
Detection Of Esterase Activity Converting Cytotoxic Renieramycin M To Jorunnamycin A In The Crude Enzyme Of The Nudibranch Jorunna Funebris, Dalad Waropastrakul., Khanit Suwanborirux, Wanchai De-Eknamkul, Taksina Chuanasa
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Use Of Three Thai Indigenous Vegetables As Potential Dietary Fiber Sources For Health Food Product, Jeeravu Thongdon-A., Prapaipat Klungsupya, Thanchanok Muangman, Arkachai Tantrawong, Srisak Trangvacharakul
Use Of Three Thai Indigenous Vegetables As Potential Dietary Fiber Sources For Health Food Product, Jeeravu Thongdon-A., Prapaipat Klungsupya, Thanchanok Muangman, Arkachai Tantrawong, Srisak Trangvacharakul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Solubility And Dissolution Enhancement Of Quercetin Via Preparation Of Spray Dried Microstructured Solid Dispersions, Ahmed Shawky Mohamed Ghanem, Hany Saleh, Sohair Mostafa El-Shanawany, El-Sayed Ali Ibrahim
Solubility And Dissolution Enhancement Of Quercetin Via Preparation Of Spray Dried Microstructured Solid Dispersions, Ahmed Shawky Mohamed Ghanem, Hany Saleh, Sohair Mostafa El-Shanawany, El-Sayed Ali Ibrahim
The Thai Journal of Pharmaceutical Sciences
Quercetin (QC) is a bioflavonoid characterized with poor water solubility that limits its oral bioavailability and hence its therapeutic applications. เท an attempt to enhance its solubility and dissolution rate, both binary and ternary microstructur...
Bioequivalence Study Of 300 Mg Irbesartan Film-Coated Tablets Preparations In Healthy Thai Volunteers, Porranee Puranajoti, Peerawong Werarak, Burapat Intawong, Jarunee Hongrapipat, Rungrudee Talubsri, Soravee Sangsuriyawong, Temsiri Kuamsuk
Bioequivalence Study Of 300 Mg Irbesartan Film-Coated Tablets Preparations In Healthy Thai Volunteers, Porranee Puranajoti, Peerawong Werarak, Burapat Intawong, Jarunee Hongrapipat, Rungrudee Talubsri, Soravee Sangsuriyawong, Temsiri Kuamsuk
The Thai Journal of Pharmaceutical Sciences
Irbesartan, an angiotensin II receptor antagonist, is indicated for the treatment of essential hypertension alone or in combination with other antihypertensive agents. The purpose of this study was to compare the bioavailability of two formulations of ir...
Quantitative Analysis Of Epigallocatechin Gallate In Young And Mature Assam Tea Leaf Extracts, Pattra Ahmadi Pirshahid, Thongchai Hemthanon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul
Quantitative Analysis Of Epigallocatechin Gallate In Young And Mature Assam Tea Leaf Extracts, Pattra Ahmadi Pirshahid, Thongchai Hemthanon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Pilot Study Of Antibacterial And Antiinflammatory Activities Of Indian Gooseberry (Phyllanthus Emblica L. Extract) Against Bacteria Associated With Pitted Keratolysis, Rattanasiri Giwanon., Krittiva Thisayakom, Pongsatom Limsiriwong, Saowaluck Ruengsri, Vichein Kheuynok, Kanchana Sriyam, Marudech Srisom, Darunee Pahusee, Sawai Nakakaew, Natthachest Ketmanee, Sontaya Peungsumrong, Chulerattana Banchonglikitkul
Pilot Study Of Antibacterial And Antiinflammatory Activities Of Indian Gooseberry (Phyllanthus Emblica L. Extract) Against Bacteria Associated With Pitted Keratolysis, Rattanasiri Giwanon., Krittiva Thisayakom, Pongsatom Limsiriwong, Saowaluck Ruengsri, Vichein Kheuynok, Kanchana Sriyam, Marudech Srisom, Darunee Pahusee, Sawai Nakakaew, Natthachest Ketmanee, Sontaya Peungsumrong, Chulerattana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Radical-Scavenging And Cellular Dna Protective Activities Of Active Fractions From Lansivm Domesticum Corr. Fruit, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul
Radical-Scavenging And Cellular Dna Protective Activities Of Active Fractions From Lansivm Domesticum Corr. Fruit, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Cytotoxic Evaluation Of A Fruit Extract From Zanthoxylum Limonella In Human Dermal Fibroblast Cell Line Using Mtt Assay, Sarunva Laovitthayanggoon., Buppachart Potduang, Natthachest Ketmanee, Chuleratana Banchonglikitkul
Cytotoxic Evaluation Of A Fruit Extract From Zanthoxylum Limonella In Human Dermal Fibroblast Cell Line Using Mtt Assay, Sarunva Laovitthayanggoon., Buppachart Potduang, Natthachest Ketmanee, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Fabrication Of Meloxicam Taste-Masked Oral Fast Disintegrating Tablet By Ion Exchange Resin And Cyclodextrin, Wipada Samprasit, Theerasak Rojanarata, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Praneet Opanasopit
Fabrication Of Meloxicam Taste-Masked Oral Fast Disintegrating Tablet By Ion Exchange Resin And Cyclodextrin, Wipada Samprasit, Theerasak Rojanarata, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Praneet Opanasopit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Development Of Garcinia Mangostana Extract In Liquid Crystal Cream For Topical Delivery System, Napa Bunma, Jirapan Moungjaroen, Prasan Tanguenyongwatana
Development Of Garcinia Mangostana Extract In Liquid Crystal Cream For Topical Delivery System, Napa Bunma, Jirapan Moungjaroen, Prasan Tanguenyongwatana
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Formulation Of Ketoprofen Matrix Membrane For Transdermal Delivery Systems, Jirapomehai Suksaeree, Wiwat Pichayakorn, Chaowalit Monton, Apirak Sakunpak, Tun Chusut, Worawan Saingam, Fameera Madaka
Formulation Of Ketoprofen Matrix Membrane For Transdermal Delivery Systems, Jirapomehai Suksaeree, Wiwat Pichayakorn, Chaowalit Monton, Apirak Sakunpak, Tun Chusut, Worawan Saingam, Fameera Madaka
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Cosmeceutical Development Of Oxyresveratrol From Mahad (Artocarpus Lakoocha Roxb.), Surapol Natakankitkul, Nicha Chareonmuang, Tawan Panyakhong, Worrapon Wangkananon
Cosmeceutical Development Of Oxyresveratrol From Mahad (Artocarpus Lakoocha Roxb.), Surapol Natakankitkul, Nicha Chareonmuang, Tawan Panyakhong, Worrapon Wangkananon
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Time Kill Study Of The In Vitro Activity Of Tigecycline Against Carbapenem-Resistant Klebsiella Pneumoniae, Maimun Halee, Wanchai Treyaprasert, Pompan Koomanachai, Duangdao Waywa
Time Kill Study Of The In Vitro Activity Of Tigecycline Against Carbapenem-Resistant Klebsiella Pneumoniae, Maimun Halee, Wanchai Treyaprasert, Pompan Koomanachai, Duangdao Waywa
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma, Jennifer M. Rothberg
Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma, Jennifer M. Rothberg
Wayne State University Dissertations
Among the non-cellular microenvironmental factors that contribute to malignancy of solid tumors is an acidic peritumoral pH. The first objective was to determine if an acidic extracellular pH observed in vivo (i.e., pHe 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when grown in biologically relevant three-dimensional cultures. At pHe 6.8 there were increases in pericellular active cysteine cathepsins and in degradation of DQ-collagen IV, which was partially blocked by a cathepsin B inhibitor. Imaging probes for active cysteine cathepsins localized to tumors in vivo. The amount of …
Progress Towards Understanding Of Mechanisms Of Action Of Potent Multifunctional Disease Modifying Therapeutics For Parkinson's Disease & Investigating The Methamphetamine-Induced Striatal Microglia Activation., Mrudang M. Shah
Wayne State University Dissertations
PROGRESS TOWARDS UNDERSTANDING OF MECHANISMS OF ACTION OF POTENT MULTIFUNCTIONAL DISEASE MODIFYING
THERAPEUTICS FOR PARKINSON'S DISEASE.
by
MRUDANG MANOJKUMAR SHAH
December 2013
Advisor: Dr. Aloke Dutta
Major: Pharmaceutical Sciences
Degree: Doctor of Philosophy
Our long term goal is to design and develop potent multifunctional disease modifying therapeutics for Parkinson's disease. The objective of my dissertation was to understand the mechanisms of action of some potent small molecules (synthesized in our lab) as a disease modifying Parkinson's disease therapeutic. The objective was achieved by pursuing the following two specific aims:
1. Investigating anti-oxidant and neuroprotective effects of a lead molecule (D-512) …
Formulation And Evaluation Of Verapamil Hydrochloride Transmucosal Drug Delivery System, Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru
Formulation And Evaluation Of Verapamil Hydrochloride Transmucosal Drug Delivery System, Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru
The Thai Journal of Pharmaceutical Sciences
Verapamil hydrochloride is an antihypertensive agent which undergoes extensive first pass metabolism making it a possible candidate for buccal delivery. Verapamil mucoadhesive buccal patches were prepared using hydroxypropyl methylcellulose, Eudragit RL ...
Development And Validation Of A Simple Stability Indicating Uplc Method For The Determination Of Repaglinide In Pharmaceuticals, Cjjo M. Xavier, Kanakapura Basavaiah
Development And Validation Of A Simple Stability Indicating Uplc Method For The Determination Of Repaglinide In Pharmaceuticals, Cjjo M. Xavier, Kanakapura Basavaiah
The Thai Journal of Pharmaceutical Sciences
A simple, precise and accurate stability-indicating isocratic reverse phase ultra-performance liquid chromatographic (RP-UPLC) method was developed for the determination of repaglinide (RPG) in bulk drug and in its tablets. The method was developed using Waters Aquity BEH C18 (100 Ó 2.1) mm, 1.7 μm column with mobile phase consisting of a mixture of potassium dihydrogen phosphate buffer of pH 3.2 and acetonitrile (40:60 v/v). The total run time for the assay was only 4 min. The eluted compound was detected at 245 nm with an UV detector. The standard curve of mean peak area versus concentration showed an excellent linearity …
Selective And Sensitive Assay Of Mebendazole In Pharmaceuticals Using Bromocresol Green By Spectrophotometry, N. Swamy, K. Basavaiah
Selective And Sensitive Assay Of Mebendazole In Pharmaceuticals Using Bromocresol Green By Spectrophotometry, N. Swamy, K. Basavaiah
The Thai Journal of Pharmaceutical Sciences
Three new, simple, rapid and sensitive spectrophotometric methods have been developed for the assay of mebendazole (MBD) in bulk drug, tablets and suspension. First method (method A) is based on the formation of a colored ion-pair complex (1:1 drug/dye) ...
Effect Of Ethanol Concentration On Cyanidin-3-Glucoside, Total Monomeric Anthocyanins, Total Phenolic Content And Radical Scavenging Properties In Purple Corn (Zea Mays L.) Seed And Cob., Penpan Srithong, Tanwarat Kajsongkram, Chuleratana Bangchonglikitkul, Waraporn Boonsupthip
Effect Of Ethanol Concentration On Cyanidin-3-Glucoside, Total Monomeric Anthocyanins, Total Phenolic Content And Radical Scavenging Properties In Purple Corn (Zea Mays L.) Seed And Cob., Penpan Srithong, Tanwarat Kajsongkram, Chuleratana Bangchonglikitkul, Waraporn Boonsupthip
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Comparison Of Hplc And Tlc Densitometric Methods For The Quantification Of Rhein In Cassia Fistula Pod Pulp Extract, Savita Chewchinda, Pongtip Sithisam, Wandee Gritsanapan
Comparison Of Hplc And Tlc Densitometric Methods For The Quantification Of Rhein In Cassia Fistula Pod Pulp Extract, Savita Chewchinda, Pongtip Sithisam, Wandee Gritsanapan
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Nutritional Values And Tlc Fingerprint Of Scaphium Scaphigerum Fruit Gel, Wichittra Phlicharoenphon., Wandee Gritsanapan, Pongtip Sithisarn
Nutritional Values And Tlc Fingerprint Of Scaphium Scaphigerum Fruit Gel, Wichittra Phlicharoenphon., Wandee Gritsanapan, Pongtip Sithisarn
The Thai Journal of Pharmaceutical Sciences
No abstract provided.