Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemistry, Biophysics, and Structural Biology (12)
- Molecular Biology (9)
- Medicine and Health Sciences (8)
- Medicinal Chemistry and Pharmaceutics (6)
- Medical Specialties (5)
-
- Oncology (5)
- Cell Biology (4)
- Cell and Developmental Biology (4)
- Toxicology (4)
- Biochemistry (3)
- Medical Sciences (2)
- Neurosciences (2)
- Alternative and Complementary Medicine (1)
- Bioinformatics (1)
- Biology (1)
- Environmental Health and Protection (1)
- Environmental Sciences (1)
- Genetics (1)
- Genetics and Genomics (1)
- Mental and Social Health (1)
- Microbiology (1)
- Nutrition (1)
- Physical Sciences and Mathematics (1)
- Physiology (1)
- Psychiatric and Mental Health (1)
- Virology (1)
- Keyword
-
- Antifolate (2)
- Breast cancer (2)
- Cancer (2)
- Diabetes (2)
- Folate (2)
-
- Proteolysis (2)
- ROS (2)
- Triple negative breast cancer (2)
- 3D culture (1)
- 5-HT1AR (1)
- 6-substituted pyrrolo[2,3-d]pyrimidine antifolates, acidic tumor microenvironment, antifolates, Proton-coupled folate transporter, solid tumor targeting (1)
- ALDH5A1, Breast, Ductal Carcinoma in situ, microarray, RNA Sequencing (1)
- AMPK (1)
- ARF6 (1)
- ARNO (1)
- Acidic pH (1)
- Adenosine A2B receptor (1)
- Adverse remodeling (1)
- Alpha-Glucosidases (1)
- Alternative splicing (1)
- Antioxidant (1)
- Apoptosis (1)
- Arsenic (1)
- Autophagosome, Autophagy, Cationic amphiphilic drugs, Cytoskeleton, Niemann Pick Type C, Trafficking (1)
- Autoreceptor (1)
- Beas-2B (1)
- Breast Cancer (1)
- CaMKK beta (1)
- Calcium channel blockers (1)
- Cancer biology (1)
Articles 31 - 33 of 33
Full-Text Articles in Pharmacology
Small Gtp-Binding Proteins In Insulin Secretion, Bhavaani Jayaram
Small Gtp-Binding Proteins In Insulin Secretion, Bhavaani Jayaram
Wayne State University Dissertations
Type 2 diabetes mellitus is marked by a substantial beta-cell failure which is characterized by defective insulin secretion and resistance to insulin. Understanding the molecular events leading to Glucose-stimulated insulin secretion [GSIS] might serve as therapeutic potential towards diabetes. GSIS involves interplay between small G-proteins and their regulatory factors. Herein, I tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange factor [GEF] for the small G-protein Arf6, mediates the activation of Arf6, and that ARNO/Arf6 signaling axis, in turn, controls the activation of downstream effectors. Salient features of my study are: [i] ARNO/Arf6 is expressed …
Mechanisms Of Regulation Of Islet Function By Nadph Oxidase, Ismail Syed
Mechanisms Of Regulation Of Islet Function By Nadph Oxidase, Ismail Syed
Wayne State University Dissertations
Glucose stimulated insulin secretion (GSIS) involves a series of metabolic and cationic events, leading to translocation of insulin-laden secretory granules from a distal site toward the plasma membrane for fusion and release of insulin into circulation. Vesicular transport and fusion events are tightly regulated by signals which coordinate between vesicle- and membrane-associated docking proteins. It is now being accepted that reactive oxygen species [ROS] plays a second messenger role in islet â-cell function. Further, evidence from multiple laboratories suggests a tonic increase in ROS generation is necessary for GSIS and fatty acid-induced insulin secretion. On the other hand, excessive ROS …
A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer, Mary Elizabeth Irwin
A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer, Mary Elizabeth Irwin
Wayne State University Dissertations
Breast cancer can be divided into genetic sub-types including luminal, HER2+, and basal-type. With the introduction of targeted therapies against estrogen receptor and HER2 receptor mortality rates of American women with breast cancer have declined. Unfortunately, basal-type breast cancers, which have the worst clinical outcome, do not express estrogen receptor or HER2, and as such, have no targeted therapeutic option. The epidermal growth factor receptor is an attractive target for therapeutics in basal-type breast cancer, as it is over-expressed in 60% of these cases. Also, over-expression of EGFR correlates with poor patient prognosis. Unfortunately, inhibitors of EGFR have shown little …