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Articles 31 - 60 of 1530
Full-Text Articles in Pharmacology
Anti-Diabetic Effect Of Interruptins A And B From Cyclosorus Terminans On Mouse Hepatocytes, Sujinda Songtrai, Sireewan Kaewsuwan
Anti-Diabetic Effect Of Interruptins A And B From Cyclosorus Terminans On Mouse Hepatocytes, Sujinda Songtrai, Sireewan Kaewsuwan
The Thai Journal of Pharmaceutical Sciences
Interruptin B from the fern Cyclosorus terminans has been indicated as a ligand of peroxisome proliferator-activated receptor (PPAR)-α and -γ that is known to regulate glucose homeostasis. Interruptin B was previously been implicated to promote glucose consumption into adipocytes. This study aimed to examine the anti-diabetic impact of interruptins A and B on glucose uptake and glycogen synthesis in mouse hepatocytes. Cell viability of FL83B hepatocytes affected by interruptins A and B was determined. The glucose consumption after 12–24 h treatment with compounds was evaluated by glucose oxidase method. The glycogen content was assessed after 24 h incubation using anthrone …
Assessment Of Risk Factors And Prescription Analysis Among Embolic And Atherosclerotic Stroke Patients In A Charitable Hospital-A Retrospective Study, Shanty Mary Jose, Amala Johnson, Akshay Abraham, Uday Venkat Mateti, Adithi Kellarai, Raushan Kumar Chaudhary, Shraddha Shetty
Assessment Of Risk Factors And Prescription Analysis Among Embolic And Atherosclerotic Stroke Patients In A Charitable Hospital-A Retrospective Study, Shanty Mary Jose, Amala Johnson, Akshay Abraham, Uday Venkat Mateti, Adithi Kellarai, Raushan Kumar Chaudhary, Shraddha Shetty
The Thai Journal of Pharmaceutical Sciences
Purpose: Despite the burden of stroke globally, there is a lack of data on the current clinical profile of stroke in middle and low-income countries including, India. Hence, the purpose of this study was to identify risk factors, clinical presentations, and importantly, prescription trends in ischemic stroke patients. Methods: A retrospective study was conducted for six months using data of 350 ischemic stroke patients for the analysis of risk factors and prescription pattern. Results: The incidence of ischemic stroke was higher (66%) in males in compared to (34%) females with mean age of 61.07 ± 11.460. Further the atherosclerotic stroke …
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur
The Thai Journal of Pharmaceutical Sciences
Objectives: Methotrexate (MTX) is a biopharmaceutics classification system Class IV drug having potential cytotoxic action against cancer cells. However, short half-life and poor bioavailability have limited its application. The object of this work was to entrap MTX and an herbal bioenhancer in a nanoparticle system to improve its bioavailability. Methods: We prepared the nanoparticles (NPs) by emulsion solvent evaporation method with Eudragit RLPO (ERLPO) polymer. Results: The result revealed good in vitro properties with 110 to 228 nm particle size range. The percentage of drugs released from all the batches in 72 h was within the range of 82.71 to …
Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil
Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil
The Thai Journal of Pharmaceutical Sciences
Aim: The current investigation work sums up the enumerating improvement and depiction of brinzolamide and brimonidine tartrate ophthalmic nanoemulsion giving widened helpful effect and improved visual penetration for treating glaucoma. Methodology: Nanoemulsion was formulated using polysorbate 80, castor oil and glycerol using the continuous emulsification technique. Preliminary batches were screened subject to in vitro medication release, globule size, zeta potential, and stability with regards to accelerated and long time. Nanoemulsions were evaluated for ex vivo optical irritancy using the hen’s egg chorioallantois membrane test model. Results: Screened nanoemulsion batches showed a low mean globule width (<220 nm), higher penetrability (>75%) in comparison with …
A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar
A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar
The Thai Journal of Pharmaceutical Sciences
Background: Synergism is a well-known concept in Herbal therapies. Polyherbal aqueous extract (PH-AE) containing Gymnema sylvestre (GS), Momordica charantia, Syzygium cumini, and Mangifera indica was evaluated for Antidiabetic activity. Objective: In our continuous research, an attempt has been made to explore GS aqueous extract (GS-AE) and its Polyherbal composite for diabetes to achieve greater efficacy. Methods: The antidiabetic activity was assessed in Streptozotocin induced diabetic rats and histopathological changes in Pancreas were documented after screening acute toxicity of both extracts. Results: Chromatographic separation and identification of GS-AE revealed the presence of Saponins and glycosides, which have also been confirmed in …
Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini
Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini
The Thai Journal of Pharmaceutical Sciences
Oral cancer is the sixth-largest kind globally of cancer and a major health issue in India as well and affects a large population that is very vulnerable to recurrences and a lower survival rate among all the other malignancies. Milk thistle is a phytochemical herb of interest that has been used as folk medicine since ancient times. Due to its potential benefits, the pharmaceutical industrial world is widely using silymarin (an active component of milk thistle) for commercial preparations. Knowing the quantity and identity of active components is of utmost importance. Therefore, robust, accurate, and precise analytical methods are needed …
Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya
Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya
The Thai Journal of Pharmaceutical Sciences
Diabetes is the third most customary non-infectious disease occurring worldwide and leads to untimely disability and mortality. This metabolic disorder is characterized by impaired insulin secretions and high blood glucose levels. Among others, type 2 diabetes is the most common. Various chemical and biochemical hypoglycemic drugs are utilized to control and treat hyperglycemia but required further interventions to reduce their toxicity and side effects on the users. Edible mushrooms have been employed from ancient times to heal many diseases as it composed of anti-oxidant, alkaloids, fibers, triterpenoids, and other phytochemicals. The bioactive secondary metabolites of mushrooms can improve insulin resistance …
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
The Thai Journal of Pharmaceutical Sciences
In this study, sugars (glucose, fructose, and sucrose) and amino acids in plum and yuzu wines were quantified with a new and simple method involving an electrochemical detector (ECD) and core–shell column (S-30/70 = Styrene/divinylbenzene – 5 tetramethyldiaminohexane). Analysis was conducted under the following conditions: A column temperature (40°C), flow rate (0.3 mL/min), injection volume (20 μL), and mobile phase (0.1 mol/L NaOH). Glucose, fructose, and sucrose had retention times of 14.68 min, 16.22 min, and 19.29 min, respectively, when measured using an ECD. When the sugar content was compared among the plum wines, plum wine A had the lowest …
Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain
Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain
The Thai Journal of Pharmaceutical Sciences
Background: Tithonia diversifolia has been widely developed as an anticancer therapy. Our previous study before showed that T. diversifolia was able to inhibit cell proliferation and collagen accumulation of keloid fibroblasts and decrease the index of rabbit scar hypertrophy. The acute dermal toxicity study of T. diversifolia gel formulation did not show toxic effect for 14 days and the LD50 was estimated more than 2%. However, toxicity data subchronic dermal toxicity study was not available for this T. diversifolia gel formulation. Objectives: Our study aimed to evaluate the subchronic dermal toxicity of T. diversifolia gel formulation in rats. Materials and …
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone
The Thai Journal of Pharmaceutical Sciences
Purpose: Fluocinolone acetonide (FA) preparations were developed in the forms of premicroemulsion concentrates and microemulsions and their stabilities were evaluated. Materials and Methods: A pseudoternary diagram of clove oil, surfactant mixture (containing polysorbate80: Polyethylene glycol 400 [PEG400] at the ratio of 2:1), and water was constructed for the formulation of FA premicroemulsion concentrates and microemulsions. Physical properties and chemical stabilities of the preparations were monitored in the absence and presence of three antioxidants. Their beyond-use dates were determined. Results and Discussion: The premicroemulsion concentrates and microemulsions containing polysorbate 80, PEG400, and clove oil successfully improved FA solubility. Average diameters of …
Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar
Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar
The Thai Journal of Pharmaceutical Sciences
Background: The objective of the present investigation was to design and evaluate the antiurolithiatic activity of extract of Tribulus terrestris, Bryophyllum pinnatum, and Cyperus rotundus on ethylene glycol-induced urolithiasis in Wistar albino rats using Box Behnken Design. To induce urolithiasis, 0.75% w/v ethylene glycol was administered orally to the rats for 28 days. Cystone 750 mg/kg was selected as the reference standard as a preventive dose. On the 28th day, urine discharged in 24 h was collected and subjected for estimation of various biochemical parameters which were evaluated using urine, serum, and kidney homogenate. The kidneys were also sectioned and …
Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu
Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu
The Thai Journal of Pharmaceutical Sciences
Objectives: Dexamethasone (Dex) is an anti-inflammatory drug with serious side effects. The aim of this study was to investigate, antioxidants status, antihyperlipidemic activity, and serum electrolyte levels of rats treated with Vitamin E in Dex-induced oxidative stress. Materials and Methods: Wistar rats of both sexes were assigned to four groups (n = 6). The control group was fed with standard rat feed and water, while Dex group received 30 μg/kg of Dex. Vitamin E group received 300 IU/kg of vitamin E, while Dex + Vitamin E group received 30 μg/kg of Dex and 300 IU/kg of vitamin E. After 14 …
Diversity And Lipolytic Activity Of Lactic Acid Bacteria Isolated From Fermented Foods And Plant Materials In Thailand, Sujitra Techo, Nattakorn Kuncharoen, Somboon Tanasupawat
Diversity And Lipolytic Activity Of Lactic Acid Bacteria Isolated From Fermented Foods And Plant Materials In Thailand, Sujitra Techo, Nattakorn Kuncharoen, Somboon Tanasupawat
The Thai Journal of Pharmaceutical Sciences
Lactic acid bacteria (LAB) originated from fermented foods, are generally known to possess the lipolytic activity which provides the desirable flavor of the products. However, the researches on their lipolytic activity are limited. Therefore, LAB with lipolytic activity derived from traditional fermented foods and plants in Thailand were isolated and identified based on the phenotypic characteristics and 16S rRNA gene sequences. The isolates were identified as Lactiplantibacillus pentosus (four isolates), Lactiplantibacillus plantarum (three isolates), Limosilactobacillus fermentum (four isolates), Enterococcus hirae (two isolates), and each isolate of Lactiplantibacillus paraplantarum, Companilactobacillus tucceti, Companilactobacillus farciminis, Lacticaseibacillus porcinae, Lactobacillus amylovorus, Pediococcus pentosaceus, and Enterococcus …
Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel
Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel
The Thai Journal of Pharmaceutical Sciences
Background: Cardiovascular diseases (CVDs) are a category of heart and blood vessel disorders that include coronary disorders, cerebrovascular diseases, rheumatic pain, and other conditions. One of the major risk factors for CVDs is high blood pressure (BP). Furthermore, it is poorly managed due to a lack of understanding of hypertension, a lack of proper primary care, and a lack of follow-up. The patient education improves the patient’s response to the disease and its management and their quality of life. Objectives: The objectives of this study were to evaluate the effect of clinical pharmacist intervention by the provision of patient counseling, …
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Thai Journal of Pharmaceutical Sciences
Brevundimonas diminuta (B. diminuta) is found in the health-care environment and in the community. At present, there are few reports of infections caused by this microorganism, especially in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A 44-year-old woman undergoing CAPD was diagnosed with a B. diminuta infection. Ceftriaxone was given both intravenously and intraperitoneally. After treatment with ceftriaxone, the peritoneal dialysis fluid white cell count, neutrophil count, and symptoms improved. To the best of our knowledge, this is the first case report of a B. diminuta infection in a patient had undergoing CAPD in Thailand
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit
The Thai Journal of Pharmaceutical Sciences
Objective: Regardless of effective harm reduction services (HRS) in Thanyarak Hospital, difficulties exist while implementing them in community hospitals. This study aimed to investigate the complexities of HRS implementation in two community hospitals in Mae Hong Son. Methods: Phase 1, in-depth interviews were conducted with 21 participants to investigate the complexity of HRS dissemination. An interview guide was developed from the seven domains of the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework, and thematic analysis was used. Phase 2 involved two rounds of a Delphi technique with 17 experts to evaluate the HRS’s complexity level (complex, complicated, simple). Results: Although …
In Situ Hyaluronic Acid-Based Hydrogel Incorporated With Insulin-Like Growth Factor-1 For Three-Dimensional Encapsulation Of Keratinocytes, Pornsuda Lengwan, Pithi Chanvorachote
In Situ Hyaluronic Acid-Based Hydrogel Incorporated With Insulin-Like Growth Factor-1 For Three-Dimensional Encapsulation Of Keratinocytes, Pornsuda Lengwan, Pithi Chanvorachote
The Thai Journal of Pharmaceutical Sciences
Background/Aim: This work aimed to establish in situ hydrogel formation based on crosslinking of methacrylated hyaluronic acid (MeHA) and the polymer incorporated with insulin-like growth factor 1 (IGF-1) for keratinocyte three-dimension (3D) culture. Materials and Methods: The compatibility of human keratinocytes with developed hydrogel was determined by PrestoBlueTM cell viability assay. The live and dead cells were determined by Calcein AM, Propidium Iodide and Hoechst 33342 staining. The physical properties including gelation time, microstructure (porosity and interconnectivity), swelling ratio, and stability of the different concentration hydrogel were determined and correlated to cell viability. Results: Three percent w/v MeHA for in …
Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty
Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty
The Thai Journal of Pharmaceutical Sciences
Background: Compelling evidence has implicated oxidative stress as a leading mechanism for arsenic (As)-induced pathologies. We evaluated antioxidant effect of virgin coconut oil (VCO) against arsenic-induced oxidative stress-mediated hepatorenal damage in rats. Methods: Rats were randomly divided into three groups: Control group, as group, and VCO + As group. VCO was orally administered before and along with arsenic (10 mg/kg body weight, orally) for 21 days. Subsequently, serum liver enzymes, albumin (ALB), creatinine, urea, antioxidant enzymes, malondialdehyde, and nitric oxide (NO) level were evaluated. The histology of the tissues was analyzed with standard procedures. Results: Arsenic caused marked increases in …
Recent Advancements On Biological Activity Of Indole And Their Derivatives: A Review, Punet Kumar, Md Iftekhar Ahma, Sangam Singh, Mohammad Rizki Fadhil Pratam, Arun K. Mishra
Recent Advancements On Biological Activity Of Indole And Their Derivatives: A Review, Punet Kumar, Md Iftekhar Ahma, Sangam Singh, Mohammad Rizki Fadhil Pratam, Arun K. Mishra
The Thai Journal of Pharmaceutical Sciences
Indole, a versatile outstanding heterocyclic compound, engaged in numerous pharmacological properties due to their multiple biochemical processes. The remarkable indole moiety resembles with numerous protein structures. The fascinating molecular framework of indole makes its suitable for drug development. Indole derivatives mimic the peptides structure and bind reversibly to several enzymes, which contribute enormous opportunities to develop novel drugs with distinct mechanism of action. The presence of nitrogen-based heterocycles in several compounds has been investigated enormously as the core structures comprise several biologically appropriate molecules found active in different diseases. The investigations conducted worldwide have shown outstanding impact for scientists, working …
Metabolite Profiling And Activity Study Of Ethanol Extract Of Chrysophyllum Cainito L. Leaves In Increasing Bone Density In Male Mice, Burhan Ma’Arif, Kurniawan Hidayat Perdana Putra, Miftah Saiful ‘Arifin, Rukiana, Reyhan Amiruddin, Weka Sidha Bhagawan, Arief Suryadinata, Fidia Rizkia Inayatilah, Roihatul Muti’Ah, Agnis Aditama
Metabolite Profiling And Activity Study Of Ethanol Extract Of Chrysophyllum Cainito L. Leaves In Increasing Bone Density In Male Mice, Burhan Ma’Arif, Kurniawan Hidayat Perdana Putra, Miftah Saiful ‘Arifin, Rukiana, Reyhan Amiruddin, Weka Sidha Bhagawan, Arief Suryadinata, Fidia Rizkia Inayatilah, Roihatul Muti’Ah, Agnis Aditama
The Thai Journal of Pharmaceutical Sciences
Phytoestrogen is a group compound which has an estrogen-like structure or function. One of its roles was in the bone formation. Chrysophyllum cainito L. is a plant that contains phytoestrogen. The purpose of this research is to determine the metabolite profile and activity of1ethanolpextract of C. cainitoxleaves to increase trabecular femur bone density in male mice. The metabolite profiling analysis was done using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry/mass spectrometry and analyzed using Masslynx 4.1 software. Four doses of ethanol extract of C. cainito leaves were prepared for treatment. Which are 2,14,48, and 316 mg/ body weight (BW) mice/day …
Acute And Sub-Acute Toxicity Profile Of Methanol Leaf Extract Of Geophila Obvallata On Renal And Hepatic Indices In Wistar Rats, Osafanme Lucky Iserhienrhien, Paulinus Ngozi Okolie
Acute And Sub-Acute Toxicity Profile Of Methanol Leaf Extract Of Geophila Obvallata On Renal And Hepatic Indices In Wistar Rats, Osafanme Lucky Iserhienrhien, Paulinus Ngozi Okolie
The Thai Journal of Pharmaceutical Sciences
Introduction: Geophila obvallata (Rubiaceae) is a medicinal herb used for the treatment of diseases associated with oxidative damage. Objective: The study investigated the toxic effects of acute and sub-acute oral doses of methanol extracts of G. obvallata (GOE) in rats. Materials and Methods: In acute toxicity study, extract doses of 1600, 2900, and 5000 mg/kg were orally administered. The rats were observed for signs of toxicity for 2 weeks. In sub-acute toxicity study, the extract was administered to rats at doses of 100, 500, and 1000 mg/kg for 28 days, while control rats received only water. At the end of …
Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line, Dini Kesuma, Anwar Medika, Tegar Achsendo Yuniarta
Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line, Dini Kesuma, Anwar Medika, Tegar Achsendo Yuniarta
The Thai Journal of Pharmaceutical Sciences
Introduction: Urea- and thiourea-based compound has shown a potency to be further developed as anticancer compound. Objective: Another novel phenylthiourea analog (N-(2,4-dichloro)benzoyl-N’-phenylthiourea) was synthesized through Schotten-Baumann reaction followed by the assessment of its cytotoxic activity. Methods: N-(2,4-dichloro)benzoyl-N’-phenylthiourea was synthesized using N-Phenylthiourea and 2,4-dichlorobenzoyl chloride as starting materials. The reaction started at low temperature for 30 min followed by reflux for 8 h to yield target compound. Cytotoxicity assay was then performed against MCF-7, T47D, and Vero normal cell line. Results: The compound has been synthesized and its structure has been verified using infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR, various 2D …
Job Scheduling For Stability Testing Of Pharmaceutical Products Using Mathematical Model, Kantanat Pridaphatrakun, Nuchanad Bunkerd, Netnawee Umin, Narueporn Sutanthavibul, Wipawee Tharmmaphornphilas, Phanphen Wattanaarsakit
Job Scheduling For Stability Testing Of Pharmaceutical Products Using Mathematical Model, Kantanat Pridaphatrakun, Nuchanad Bunkerd, Netnawee Umin, Narueporn Sutanthavibul, Wipawee Tharmmaphornphilas, Phanphen Wattanaarsakit
The Thai Journal of Pharmaceutical Sciences
The pharmaceutical industry plays an important role in the nation’s economy and society since pharmaceutical products are one of the factors that affect people’s lives and their health. At present, the domestic pharmaceutical industry is developing and adapting to meet the needs of customers and is also very competitive. Therefore, each stage of the production process must be as efficient as possible to achieve competitive advantages without compromising the product quality. One important process in production is pharmaceutical product stability testing, which ensures that the products have the necessary quality, efficacy, and safety. Managing time in a way that maximizes …
Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin, Rungpetch Sakulbumrungsil
Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
Inventory management analysis for a state-level hospital pharmacy of Myanmar was conducted using ABC-VEN matrix analysis to identify the drug categories that require stringent management control. The annual expenditure of all drug items managed by pharmacy department for the years 2016 and 2017 was analyzed and application of ABC, VEN, and ABC-VEN matrix analysis was performed. The study showed that the average annual expenditure was 288,414 USD. Of the total 297 items of medicines, 7.7% (23), 16.8% (50), and 75.4% (224) were classified as A, B, and C category items, respectively, accounting for 70.4%, 19.7%, and 9.9% of drug expenditure. …
Effects Of The Mobile Serious Game (Herbarian) With Location-Based Learning On Students’ Retention Of Botanical Terms And Their Experiences, Sornkanok Vimolmangkang, Nattanichcha Kulthanachairojana, Taksina Chuanasa, Supotchana Sitthigool, Anuchai Theeraroungchaisri
Effects Of The Mobile Serious Game (Herbarian) With Location-Based Learning On Students’ Retention Of Botanical Terms And Their Experiences, Sornkanok Vimolmangkang, Nattanichcha Kulthanachairojana, Taksina Chuanasa, Supotchana Sitthigool, Anuchai Theeraroungchaisri
The Thai Journal of Pharmaceutical Sciences
Background: A serious game was developed from the use of learning through drill and practice principle to enhance the knowledge memorizing together with the principle of game-based learning in education application. The aim of this study was to investigate the effectiveness of using game-based and location-based learning concepts on the student knowledge score and knowledge retention score. Methods: A mobile application game named “Herbarian” was developed and used in the pharmaceutical botany course as a part of the undergraduate pharmacy curriculum. The content in the game was botanical jargon linked to plant morphology. Twenty-one and 51 undergraduate students voluntarily used …
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
The Thai Journal of Pharmaceutical Sciences
Black cumin seed oil (BSCO) is widely used to maintain health and strengthen the people of Indonesia’s immune system and proved to be safe for kidneys. However, the effect of BSCO usage in a healthy kidney is remaining unknown. This study was aimed to determine the impact of the 20-day administration of BCSO on kidney function in healthy volunteers. We conducted a pre- and post-control design trial in 36 healthy volunteers. The volunteers had to hold a valid health certificate from the hospital, be willing to be involved in the research as evidenced by their willingness to complete and sign …
Improved Virus Inhibition By Microencapsulated Monoclonal Antibody Against Porcine Epidemic Diarrhea Virus, Rachatapan Junchay, Patcharapong Thangsunan, Kittipat Supchukun, Jakarwan Yostawonkul, Sasithon Temisak, Kaewta Rattnapisit, Teerapong Yata, Waranyoo Phoolcharoen
Improved Virus Inhibition By Microencapsulated Monoclonal Antibody Against Porcine Epidemic Diarrhea Virus, Rachatapan Junchay, Patcharapong Thangsunan, Kittipat Supchukun, Jakarwan Yostawonkul, Sasithon Temisak, Kaewta Rattnapisit, Teerapong Yata, Waranyoo Phoolcharoen
The Thai Journal of Pharmaceutical Sciences
Porcine epidemic diarrhea virus (PEDV) has been affecting the swine industry, especially in suckling pigs with a high mortality rate. Among all the strategies to overcome PEDV, boosting mucosal immunity in the pig intestines through oral administration appears to be more efficient than other routes. However, there are biological obstacles such as an acidic environment that could damage biologics, a product from organisms often used for PEDV treatment. The plant-derived 2C10 monoclonal antibody (mAb) from Nicotiana benthamiana produced by transient expression was revealed as one of the potential candidates against PEDV through oral delivery. Herein, we demonstrated the calcium-alginate microencapsulation …
The Impact Of Pharmacists’ Interventions In Female Internal Medicine Ward At University-Based Hospital On Cost Savings And Cost Avoidance, Tanatape Wanishayakorn, Orawan Sae-Lim, Onnicha Suntornlohanakul, Pastraporn Yiengkulchao, Prayut Muangming, Natayu Chuerdee
The Impact Of Pharmacists’ Interventions In Female Internal Medicine Ward At University-Based Hospital On Cost Savings And Cost Avoidance, Tanatape Wanishayakorn, Orawan Sae-Lim, Onnicha Suntornlohanakul, Pastraporn Yiengkulchao, Prayut Muangming, Natayu Chuerdee
The Thai Journal of Pharmaceutical Sciences
Background: Several studies have been conducted regarding the role of clinical pharmacist in the reduction of medical costs, the impact of clinical pharmacists in internal medicine wards on cost saving had been rarely studied. Objective: The objective of this study was to define the characteristics of drug-related problem (DRPs) and evaluate the effect on cost savings and cost avoidance by clinical pharmacists in female internal medicine ward at Songklanagarind Hospital. Materials and Methods: A retrospective analysis of pharmacists’ interventions recorded for 6 months was conducted. DRPs were categorized based on Pharmaceutical Care Network Europe V9.00. The interventions that were accepted …
Plaque Reduction Neutralization Test As A Method For Detecting Functional Neutralizing Antibodies Against Live Sars-Cov-2 Virus, Supaporn Phumiamorn, Skalin Trisiriwanich, Kornnika Kulabutar, Asmah Usoo, Thitiporn Somporn, Wipawee Wongchana, Sompong Sapsutthipas
Plaque Reduction Neutralization Test As A Method For Detecting Functional Neutralizing Antibodies Against Live Sars-Cov-2 Virus, Supaporn Phumiamorn, Skalin Trisiriwanich, Kornnika Kulabutar, Asmah Usoo, Thitiporn Somporn, Wipawee Wongchana, Sompong Sapsutthipas
The Thai Journal of Pharmaceutical Sciences
Introduction and objective: Since 2020, little is known about neutralizing antibody (NAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus emerging and causing COVID-19 in humans. Here, we established a plaque reduction neutralization test (PRNT) to use as a method for detecting functional NAbs to SARS-CoV-2. Materials and Method: Vero cells were used as target cells for infection with the new coronavirus and cytopathic effects were obviously exhibited. Results: The development of plaque reduction after neutralization of virus with diluted specific antiserum was assessed according to a dose-response effect and consistency of test results with pooled …