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Articles 61 - 70 of 70
Full-Text Articles in Pharmacology
Denervation Supersensitivity Of The Rat Vas Deferens: A Role For Protein Kinase C, Sonny T. Abraham
Denervation Supersensitivity Of The Rat Vas Deferens: A Role For Protein Kinase C, Sonny T. Abraham
Electronic Theses and Dissertations
A role for protein kinase C (PKC) in the denervation-induced supersensitivity of the rat vas deferens was investigated. Chronic, surgical denervation of the rat vas deferens (up to 8 days) resulted in tissues that produced enhanced contractile responses to norepinephrine (NE) in isolated organ baths. Single challenges of NE (10 $\mu$M) produced 0.6 $\pm$ 0.1 g of maximal tension in the control vas whereas in the paired, denervated tissue 2.2 $\pm$ 0.3 g of tension was recorded (n = 6). Cumulative concentration-effect curves to NE produced in the denervated vas deferens were shifted 18-fold to the left of the control …
Differential Role Of The Endothelium In Regulating Microvascular Blood Flow, Tao Tang
Differential Role Of The Endothelium In Regulating Microvascular Blood Flow, Tao Tang
Electronic Theses and Dissertations
The vascular endothelial cell (EC) plays an important role in regulating vascular tone and local blood flow by sensing chemical and mechanical stimuli on the vascular wall and releasing a host of vasoactive substances upon activations of endogenous or exogenous vasoactive substances. The central hypothesis is that local control of blood now and autoregulatory behavior in the microcirculation is distinctive at different levels of the vasculature and is dependent on the cellular activities of the EC and its interaction with the local environment. The in vivo as well as the ex vivo, flow-controlled preparations of the hamster cheek pouch were …
Co-Sensitization Of Dopamine And Serotonin Receptors Occurs In The Absence Of A Change In The Dopamine D1 Receptor Complex After A Neonatal 6-Ohda Lesion, Li Gong
Electronic Theses and Dissertations
To test whether SKF 38393 could ontogenetically sensitize dopamine (DA) D$\sb1$ receptors and whether this sensitization would be associated with biochemical changes, intact and neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats (200 $\mu$g i.c.v.) were treated daily from birth with SKF 38393 (3.0 mg/kg i.p. x 28 days) or its vehicle. In DA D$\sb1$ neonatally sensitized 6-OHDA rats, enhanced locomotor responses were observed with the first SKF 38393 challenge dose (3.0 mg/kg i.p.) at 6 weeks. This response increased further with weekly SKF 38393 treatments. Enhanced stereotyped behaviors were seen in both lesioned and sensitized rats at 8 weeks. There was no change …
Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi
Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi
Electronic Theses and Dissertations
Dopamine (DA) agonist-induced behavioral supersensitivity in the adult rat has served as the standard model for certain of the motor and behavioral side effects associated with long-term exposure to DA agonists in humans. The mechanisms relating receptor events with behavior mediation, however, remain unclear. The striatum of rats progresses through a prolonged and varied postnatal developmental period. In order to examine the relative contribution of D1 and D2 receptor-mediated mechanisms to behavioral changes which follow chronic dopamine agonist exposure, developing rats were treated daily from birth with a D1 agonist, SKF 38393 hydrochloride (3.0 mg/kg $\times$ 32d, i.p.), or a …
Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi
Dopamine Agonists Modify The Development Of Brain D1 And D2 Receptor Responsiveness, Anwar A. Hamdi
Electronic Theses and Dissertations
Dopamine (DA) agonist-induced behavioral supersensitivity in the adult rat has served as the standard model for certain of the motor and behavioral side effects associated with long-term exposure to DA agonists in humans. The mechanisms relating receptor events with behavior mediation, however, remain unclear. The striatum of rats progresses through a prolonged and varied postnatal developmental period. In order to examine the relative contribution of D1 and D2 receptor-mediated mechanisms to behavioral changes which follow chronic dopamine agonist exposure, developing rats were treated daily from birth with a D1 agonist, SKF 38393 hydrochloride (3.0 mg/kg $\times$ 32d, i.p.), or a …
Attenuation Of Antagonist-Induced Impairment Of Dopamine Receptors By L-Prolyl - L-Leucyl-Glycinamide, Mohamad I. Saleh
Attenuation Of Antagonist-Induced Impairment Of Dopamine Receptors By L-Prolyl - L-Leucyl-Glycinamide, Mohamad I. Saleh
Electronic Theses and Dissertations
It has been shown by others that the prenatal treatment of rats with haloperidol, a dopamine D2 receptor antagonist, leads to a permanent reduction in the number of striatal dopamine D2 receptors in adulthood. Conversely, postnatal treatment of lactating dams with haloperidol from birth for 21 days, leads to an increase in the number of striatal dopamine D2 receptors in the litters, when assessed as adults. The present study was undertaken in order to determine whether chronic, long-term postnatal challenge of rat pups per se, with specific dopamine D1 and D2 receptor antagonists, would modify the ontogeny of the respective …
Lung Paraquat Content And Effects On The Lung Glutathione Antioxidant System, Nadph, And Polyamines Resulting From Intravenous Coinfusion Of Paraquat And Putrescine To Rats, Jacob R. Dunbar
Electronic Theses and Dissertations
Paraquat was administered to male, Sprague-Dawley rats via continous infusion, at dosage rates of 250 (LoPQ) or 500 (HiPQ) nmoles/hr for seven days. The purpose was to characterize the effects of prolonged, low blood levels of the herbicide on selected lung biochemical parameters. The efficacy of putrescine as an inhibitor of pulmonary paraquat accumulation, in vivo, was assessed in these animals by I.V. coinfusion of 2500 or 5000 nmoles putrescine/hr. Dose-dependent levels of both paraquat and putrescine were achieved by 18 hours and were maintained throughout the exposure period. Terminal lung paraquat content was also dose-dependent and up to 18-fold …
Cisplatin Ototoxicity In The Guinea Pig: An Electrophysiological, Morphological, And Biochemical Study, Sarah E. Barron
Cisplatin Ototoxicity In The Guinea Pig: An Electrophysiological, Morphological, And Biochemical Study, Sarah E. Barron
Electronic Theses and Dissertations
The purpose of this study was to determine changes induced by cisplatin on hair cell (HC) morphology, compound action potential (CAP), Preyer reflex (PR), and Na,K-ATPase activity in the cochlear lateral wall. Guinea pigs were treated with either 0.42, 0.83, 1.17, 1.50 mg/kg cisplatin, i.p. or sterile water for 12 consecutive days and tested on day 13. HC condition was visualized with scanning electron microscopy (SEM), CAP was initiated with a 1 volt click, and Na,K-ATPase activity was measured by the method of Fiske and SubbaRow. HC damage was linear with dose and occurred throughout the turns of the cochlea …
Failure Of Opioids To Modify Noradrenergic Neuronal Recovery From A Dorsal Bundle Lesion In Neonatal Rats, Ellen L. Kunkel-Bagden
Failure Of Opioids To Modify Noradrenergic Neuronal Recovery From A Dorsal Bundle Lesion In Neonatal Rats, Ellen L. Kunkel-Bagden
Electronic Theses and Dissertations
Morphine and exogenous opioid peptides alter the development of central noradrenergic neurons damaged by neonatal treatment with the neurotoxin 6-hydroxydopa. Transection of the dorsal noradrenergic bundle (DNB) in neonatal rats produces nearly the same alteration in the developmental pattern. It was of interest to determine whether morphine or an exogenous opioid peptide (metenkephalin) was able to modify the recovery of noradrenergic neurons after neonatal surgical transection of the DNB. Neonatal rats were divided into two groups. Both groups received saline (0.85%) or naloxone (2.0 mg/kg) by the intraperitoneal (i.p.) route. In the first group the animals received an additional i.p. …
Enantiomeric Influences In Neuroleptic Binding To Models Of The Dopamine Receptor, Timothy A. Robert
Enantiomeric Influences In Neuroleptic Binding To Models Of The Dopamine Receptor, Timothy A. Robert
Electronic Theses and Dissertations
No abstract provided.