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Other Pharmacology, Toxicology and Environmental Health Commons™

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2022

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Articles 1 - 17 of 17

Full-Text Articles in Other Pharmacology, Toxicology and Environmental Health

Antibacterial, Antioxidant, And Repellency Potential Of The Essential Oil From Spartium Junceum L. Grown In Lebanon, Hawraa Zahrddin, Mahmoud Khalil, Akram Hijazi Dec 2022

Antibacterial, Antioxidant, And Repellency Potential Of The Essential Oil From Spartium Junceum L. Grown In Lebanon, Hawraa Zahrddin, Mahmoud Khalil, Akram Hijazi

BAU Journal - Science and Technology

The goal of our present study is to assess the pharmacological potential of essential oil extracted from Spartium junceum cultivated in Lebanon. This oil was obtained by hydrodistillation using the Clevenger apparatus. Then, an organoleptic characterization and an evaluation of its antioxidant, repellent/insecticidal, and antibacterial activities have been evaluated. The obtained results showed that this oil had an antioxidant activity reaching 82 % dependent on the dilution used. In addition, it showed an insecticidal effect and an antibacterial effect.

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Health Effects Of Neonicotinoids On An Agricultural Community, Jocelyn Rodriguez-Paar Dec 2022

Health Effects Of Neonicotinoids On An Agricultural Community, Jocelyn Rodriguez-Paar

Capstone Experience: Master of Public Health

Mead, Nebraska, a small United States agricultural community consisting of approximately 600 people, was accidentally exposed to high amounts of neonicotinoids when AltEn, an ethanol plant that used neonicotinoid coated corn and soybean seeds for biofuel, was discovered not disposing of the toxic byproduct safely. Coincidentally, there was also a leak in their wastewater system that also contaminated the nearby areas. Although neonicotinoids are not considered highly dangerous with low dose exposures, large dose exposures can cause symptoms similarly to nicotine poisonings, such as difficulty breathing, vomiting, nausea, hypertension, tachycardia, and lethargy (Imamura, T. et al., 2010). Neonicotinoid poisoning can …

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What Makes Mad Honey “Mad”? An Investigation Into The Obsession Of The Himalayan Wild Cliff Honey, Codi Farmer Oct 2022

What Makes Mad Honey “Mad”? An Investigation Into The Obsession Of The Himalayan Wild Cliff Honey, Codi Farmer

Independent Study Project (ISP) Collection

Mad honey is a rare variety of cliff honey found in the mountainous regions of Turkey and Nepal and has been harvested by Indigenous groups for centuries. In Nepal, it is found on high-hanging cliffs that people risk their lives to face, but what makes this honey so special to cause generations of Nepalis to brave the formidable heights? Through a series of reading primary and secondary sources, watching first-hand accounts of honey hunting, and interviewing honey hunters, filmmakers, authors, and laypeople alike, I work to find the answer to the puzzling question – what makes mad honey "mad"? In …

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Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi Sep 2022

Synthesis Of Alginate/Hydroxyapatite Beads For Acetaminophen Delivery, Anesylvia Angan, Nonni Soraya Sambudi

Makara Journal of Science

Conventional drug delivery systems usually involve the intake of multiple drugs, which could amplify the risk of overdosing. Acetaminophen is a widely used pain relief substance that is prone to accidental overdosing. Hence, a controlled drug delivery system is needed to ensure its efficacy. A nanocomposite hydroxyapatite/alginate system that was used as a drug carrier for acetaminophen was synthesized through the sol-gel method, and the mechanism underlying its controlled drug delivery was investigated. Spherical nanocomposite bead samples were synthesized by incorporating 5 wt%, 10 wt%, and 15 wt% hydroxyapatite into mixtures containing alginate. The mixtures were then dropped into calcium …

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The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr. Sep 2022

The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.

Faculty and Staff Scholarship

We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and age-related diseases which contribute to increased morbidity with age. Geriatric populations are rarely considered in the development of environmental regulations or in toxicology research. Today, life expectancy is often into one’s 80s or beyond, which means multiple decades living as a geriatric individual. Hence, adverse health effects and late-onset diseases might be due to environmental exposures as a geriatric, and we currently have no way of …

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Roles Of Oxidative Stress And Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression, Mary Figueroa Aug 2022

Roles Of Oxidative Stress And Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression, Mary Figueroa

Dissertations and Theses (Open Access)

Acute myeloid leukemia (AML) is a commonly diagnosed cancer in smokers. When current or former smokers have AML, they have worse survival compared to never smoking patients. This has been observed clinically for decades, but then it is unknown how smoking leads to worsened AML survival. Smoking causes oxidative stress and altered DNA methylation that persists for decades in peripheral blood mononuclear cells, but these changes from smoking have not been evaluated in the context of AML. We hypothesize that smoking-induced molecular changes, including altered DNA methylation associated with poor AML prognosis, promote AML. We developed a novel model to …

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Lc-Ms/Ms Method For The Detection And Quantification Of Pharmaceuticals And Drugs Of Abuse In New York City Waterways, Natalie M. Fernandez Jun 2022

Lc-Ms/Ms Method For The Detection And Quantification Of Pharmaceuticals And Drugs Of Abuse In New York City Waterways, Natalie M. Fernandez

Student Theses

The use of licit and illicit drugs has been increasing significantly over the past few years within the United States. Due to this increase, these drugs are emerging as contaminants in surface and ground water. The presence of pharmacologically active compounds in this environment can be extremely harmful to aquatic life as they are continuously exposed to these substances. The goal of this study was two-fold: 1) Develop and validate an analytical method for 28 different drugs including cocaine, amphetamines, opioids, cannabis, and prescription medicines, in river water; 2) Identify and quantify drugs found in New York City waterways over …

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Chiral Analysis Of Methamphetamine In Hair Samples, Kristen Payes May 2022

Chiral Analysis Of Methamphetamine In Hair Samples, Kristen Payes

Student Theses

Methamphetamine (MAMP) is a highly addictive illicit drug typically abused for its nervous system stimulating effects. Conversely, methamphetamine has therapeutic use treating attention deficit hyperactivity disorder, controlling appetite and assisting with weight loss, and is available as the pure l-isomer in over-the-counter (OTC) nasal inhalers due to its decongestant activity. Because l-methamphetamine (l-MAMP) is available in OTC form, forensic guidelines require a sample to contain greater than 20% d-methamphetamine (d-MAMP) when classifying results as consistent with illicit MAMP use. Chiral chromatographic analysis is capable of distinguishing between l-MAMP and d-MAMP. This …

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Assessment Of Soil, Water Contamination And Land Cover Changes In The Urban And Suburban Watersheds Of Houston, Texas, Felica Rena Davis May 2022

Assessment Of Soil, Water Contamination And Land Cover Changes In The Urban And Suburban Watersheds Of Houston, Texas, Felica Rena Davis

Dissertations (2016-Present)

Intense urbanization and increased anthropogenic activity are two important factors contributing to the decline of soil and water quality in Houston watersheds, which poses a great environmental and human health risks. This study, therefore, was designed to: 1) determine nutrient and metal concentrations in soil and water samples along Carpenters Bayou (CaB), Cedar Bayou (CB), Sims Bayou (SB), Spring Creek Bayou (SC) and Vince Bayou (VB), 2) analyze land cover changes in watersheds using Landsat image analysis and 3) evaluate socio-economic characteristics and human health risks for each watershed. Soil and water samples were collected from three different locations with …

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The Roles Of Pon2 In Mitochondrial Physiology, Lung Tumor Cell Proliferation, And Lung Tumorigenesis., Aaron Whitt May 2022

The Roles Of Pon2 In Mitochondrial Physiology, Lung Tumor Cell Proliferation, And Lung Tumorigenesis., Aaron Whitt

Electronic Theses and Dissertations

Paraoxonase 2 (PON2) is an intracellular, multifunctional enzyme with near-ubiquitous tissue distribution. Within cells, PON2 is localized to mitochondria and endoplasmic reticulum (ER), where it mitigates the formation of reactive oxygen species (ROS). PON2’s chief enzymatic function is its lactonase activity, through which it catalyzes the hydrolysis of a bacterial quorum-sensing molecule, N-(3-oxododecanoyl)-l-homoserine lactone (C12), effectively disrupting bacterial intercellular communication and protecting against infection. C12 is produced by the opportunistic pathogen Pseudomonas aeruginosa and has been shown to disrupt various aspects of eukaryotic host cell physiology and evoke apoptotic cell death through the activity of PON2. Additionally, PON2 has garnered …

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Particulate Hexavalent Chromium Inhibits Homologous Recombination Repair By Targeting Rad51 Paralogs In Human Lung Fibroblasts., Aggie R. Williams May 2022

Particulate Hexavalent Chromium Inhibits Homologous Recombination Repair By Targeting Rad51 Paralogs In Human Lung Fibroblasts., Aggie R. Williams

Electronic Theses and Dissertations

Hexavalent Chromium [Cr(VI)] is a known human lung carcinogen and general health hazard. The mechanism of carcinogenesis remains poorly understood, but chromosome instability (CIN) is the major theory in its carcinogenic mechanism. Homologous recombination (HR) repair is a DNA repair pathway that prevents CIN by repairing DNA double-strand breaks. RAD51, a key mediator protein of HR repair, along with the RAD51 paralogs (RAD51B, C, D, XRCC2, and 3) are required for HR repair. During HR, RAD51 loads and forms a helical nucleoprotein filament structure to promote DNA strand exchange and stimulate pairing activity of DNA. Cr(VI) exposures have been shown …

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Early Detection Of Atypical Motor And Neurobehavior Of Infants At Risk Secondary To Opioid Exposure: A Prospective Study, Kara Boynewicz May 2022

Early Detection Of Atypical Motor And Neurobehavior Of Infants At Risk Secondary To Opioid Exposure: A Prospective Study, Kara Boynewicz

Electronic Theses and Dissertations

Prenatal opioid exposure has been studied in relation to infants' medical outcomes. However, large gaps exist in the literature supporting early identification of atypical neurobehavior and motor development of infants with prenatal opioid exposure. The purpose of the study was to investigate whether prenatal opioid exposure has a negative influence on a newborn infant’s neurobehavior and motor development to aid in the early identification of potential delays. Using a prospective quasi experimental design, infants motor development using the Test of Infant Motor Performance (TIMP) and neurobehavior using the NICU Neonatal Network Scale (NNNS) was assessed on 58 infants in a …

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Antibacterial, Hemagglutination, And Insecticidal Activity Studies On The Solvent Extracts Of The Roots Of Olea Ferruginea, Muhammad Yaseen, Muhammad Kamran, Arshad Farid, Salmah Ismail, Muhammad Muzammal, Kamal Abdul Amir, Muhammad Hashim Khan, Sohail Ahmad, Sheikh Abdur Rashid Mar 2022

Antibacterial, Hemagglutination, And Insecticidal Activity Studies On The Solvent Extracts Of The Roots Of Olea Ferruginea, Muhammad Yaseen, Muhammad Kamran, Arshad Farid, Salmah Ismail, Muhammad Muzammal, Kamal Abdul Amir, Muhammad Hashim Khan, Sohail Ahmad, Sheikh Abdur Rashid

Makara Journal of Science

Olea ferruginea has been used to treat skin ailments, as well as kidney and ocular problems for a long time. The current study was designed with the aim of investigating and scientifically validating its widespread use. Chloroform, n-hexane, and ethyl acetate were used to assess the antibacterial, hemagglutination, and insecticidal properties of O. ferruginea roots. Escherichia coli, Micrococcus luteus, Klebsiella pneumoniae, and Pseudomonas aeruginosa were among the bacterial strains selected for assessing antibacterial activity. The results showed that ethyl-acetate (EtOAc) extract (56%) and chloroform (CHCl3) extract (56%) showed the widest zone of inhibition against …

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Lipid Based Nanoparticles As A Novel Treatment Modality For Hepatocellular Carcinoma: A Comprehensive Review On Targeting And Recent Advances, Khaled Mahmoud, Shady Swidan, Mohamed A. El-Nabarawi, Mahmoud H. Teaima Mar 2022

Lipid Based Nanoparticles As A Novel Treatment Modality For Hepatocellular Carcinoma: A Comprehensive Review On Targeting And Recent Advances, Khaled Mahmoud, Shady Swidan, Mohamed A. El-Nabarawi, Mahmoud H. Teaima

Pharmacy

Liver cancer is considered one of the deadliest diseases with one of the highest disease burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is considered to be the most common type. Multiple conventional approaches are being used in treating hepatocellular carcinoma. Focusing on drug treatment, regular agents in conventional forms fail to achieve the intended clinical outcomes. In order to improve the treatment outcomes, utilizing nanoparticles—specifically lipid based nanoparticles—are considered to be one of the most promising approaches being set in motion. Multiple forms of lipid based nanoparticles exist including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, …

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The Role Of Dichloro(Ethylenediamine) Platinum Ii In Altering Cellular Iron And Copper Transport, Megan Hall Jan 2022

The Role Of Dichloro(Ethylenediamine) Platinum Ii In Altering Cellular Iron And Copper Transport, Megan Hall

Mahurin Honors College Capstone Experience/Thesis Projects

Approximately 50% of all chemotherapy cancer patients receive a platinum chemotherapeutic during their treatment. Although these drugs are widely utilized, little is known about the cellular transport of platinum drugs. It is hypothesized that platinum utilizes transporters for other metals to enter the cell. Structural differences between compounds are predicted to affect the compounds’ ability to exploit different transporters. Also, different cell types express different transporters. Therefore, compound structure is expected to influence transport of platinum compounds differently in different cell types. This study investigated the role of the platinum drug cisplatin and platinum compound Pt(en)Cl2 in altering iron …

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Climate Change And Environmental Sustainability Module: Activity Booklet, Fozia Parveen, Sara Hassan, Subhan Khan Jan 2022

Climate Change And Environmental Sustainability Module: Activity Booklet, Fozia Parveen, Sara Hassan, Subhan Khan

Books

Dear readers (teachers, parents, and students), Thank you for accessing our activity booklet. The information booklet introduced concepts relating to climate change and environmental sustainability. In this booklet several cross cutting activities on various themes have been presented. The booklet contains ready-made activities containing but not limited to comic strips, experiments, conversations, writing, simple tag, cut and paste as well as research activities. We hope you enjoy, adapt and implement these activities in your community.

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The Exposome, Metabolic Dysfunction And Silicosis: A Pulmonary And Pathophysiology Study, Janet A. Thompson Jan 2022

The Exposome, Metabolic Dysfunction And Silicosis: A Pulmonary And Pathophysiology Study, Janet A. Thompson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The exposome encompasses the concept that an individual’s health is a combination of genetic, environmental, and occupational exposures. A worker’s exposomal profile could potentially influence their susceptibility to hazardous occupational exposures. Over 35% of adults in the United States have metabolic dysfunction (MetDys), yet interactions between MetDys and hazardous occupational exposures are generally unknown. MetDys is associated with HFWD-consumption and obesity and induces a chronic low grade systemic inflammation and alters serum adipokine profiles. Silicosis, a progressive inflammatory lung disease, results from occupational inhalation exposure to respirable crystalline silica particles. This research tests the hypothesis “Inflammation resulting from HFWD-induced …

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