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Articles 1 - 11 of 11
Full-Text Articles in Other Pharmacology, Toxicology and Environmental Health
The Effect Of Prebiotics On Intestinal Digestion Of Carbohydrates In Lead Intoxicated Rats, Lubov S. Kuchkarova, Irodakhon I. Karimova, Gulchekhra T. Kudeshova, Khasan Yu. Kayumov
The Effect Of Prebiotics On Intestinal Digestion Of Carbohydrates In Lead Intoxicated Rats, Lubov S. Kuchkarova, Irodakhon I. Karimova, Gulchekhra T. Kudeshova, Khasan Yu. Kayumov
Bulletin of National University of Uzbekistan: Mathematics and Natural Sciences
It has been shown the lead intoxication of growing rats result in increase the cavity and membrane carbohydrate hydrolysis and glucose absorption from small intestine which leads to hyperglicemiya. The oral treatment of intoxicated rats with inulin or lactulose results in decrease of carbohydrate assimilation in small intestine and content glucose level in blood. The correcting effect of lactulose on normalization of carbohydrate assimilation is more expressed in compare with inulin. So, inulin and/or lactulose take part in improving of adaptation of the carbohydrate assimilation system in the small intestine during intoxication with lead ions in growing rats. This suggests …
Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick Cullen, James Curtin
Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick Cullen, James Curtin
Articles
Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma …
Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition., Arya Emami, Shahla Shojaei, Simone C. Da Silva Rosa, Mahmoud Aghaei, Ehsan Samiei, Amir Reza Vosoughi, Forouh Kalantari, Philip Kawalec, James Thliveris, Pawan Sharma, Amir A. Zeki, Mohsen Akbari, Joseph W. Gordon, Saeid Ghavami
Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition., Arya Emami, Shahla Shojaei, Simone C. Da Silva Rosa, Mahmoud Aghaei, Ehsan Samiei, Amir Reza Vosoughi, Forouh Kalantari, Philip Kawalec, James Thliveris, Pawan Sharma, Amir A. Zeki, Mohsen Akbari, Joseph W. Gordon, Saeid Ghavami
Center for Translational Medicine Faculty Papers
Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in both 2-dimensional (2D) and 3-dimensional (3D) cell culture, we investigated the mechanisms of simvastatin's myotoxicity. We found that simvastatin significantly reduced cell viability in C2C12 cells compared to RH30 cells. However, simvastatin induced greater apoptosis in RH30 compared to C2C12 cells. Simvastatin-induced cell death is dependent on geranylgeranyl pyrophosphate (GGPP) in C2C12 cells, while in RH30 cells it is dependent on both farnesyl pyrophosphate (FPP) and GGPP. Simvastatin inhibited …
Molecular Responses To Deepwater Horizon Oil Spill Contaminants In Estuarine Fish, Elizabeth Jones
Molecular Responses To Deepwater Horizon Oil Spill Contaminants In Estuarine Fish, Elizabeth Jones
Dissertations
The 2010 Deepwater Horizon (DWH) oil spill resulted in the oiling of approximately 2100 km of shoreline. During that time, resident organisms had to contend with the effects of multiple contaminants and suboptimal environmental conditions. This research examines the molecular effects of DWH oil spill contaminants in estuarine fish (CyprinodonvariegatusandFundulusgrandis) across multiple life stages, contaminant concentrations, and in conjunction with environmental stressors.
Our results indicate that:
1. Oil elicits substantial transcriptional effects across life stages in C. variegatus. In adults, exposure to low concentrations of oil and dispersant results in transcriptional effects related …
A Pharmacokinetic Model Of Lead Absorption And Calcium Competitive Dynamics, Anca R. Radulescu
A Pharmacokinetic Model Of Lead Absorption And Calcium Competitive Dynamics, Anca R. Radulescu
Biology and Medicine Through Mathematics Conference
No abstract provided.
Herbicide Toxicity To Non-Target Aquatic Organisms Does Not Increase In Mixtures With Surfactants, Courtney L. Telfort
Herbicide Toxicity To Non-Target Aquatic Organisms Does Not Increase In Mixtures With Surfactants, Courtney L. Telfort
Honors College Theses
Agricultural herbicides enter aquatic environments after rain events where they affect microscopic aquatic plants (phytoplankton) and animals (zooplankton) that form the base of aquatic food webs. Atrazine, an herbicide with low solubility in water, is often mixed with surfactants such as alkyl polyglucoside (APG) to improve effectiveness. Although APG has low-toxicity, a potential drawback to increased atrazine solubility is greater adverse effects on aquatic organisms. I hypothesized that atrazine and APG decrease phytoplankton abundance more than atrazine alone. Specifically, I predicted phytoplankton abundance should 1) decrease with increasing concentrations of the mixture compared to the same atrazine concentrations individually, and …
Residues Of Thiamethoxam And Mefenoxam In Vegetative And Floral Tissue Of Soybean At The Early Reproductive Stage Resulting From Seed Treatments, Carolina Camargo, Daniel D. Snow, Sathaporn Onanong, Thomas Hunt, Blair Siegfried
Residues Of Thiamethoxam And Mefenoxam In Vegetative And Floral Tissue Of Soybean At The Early Reproductive Stage Resulting From Seed Treatments, Carolina Camargo, Daniel D. Snow, Sathaporn Onanong, Thomas Hunt, Blair Siegfried
Department of Entomology: Faculty Publications
Thiamethoxam with mefenoxam is the most widely used neonicotinoid insecticide/fungicide mixture applied to soybean (Glycine max [L]) as seed treatments. Based on the systemic nature of thiamethoxam and mefenoxam, residues of this insecticide/fungicide mixture may be present in soybean vegetative and floral tissue and negatively impact beneficial insects. Although neonicotinoids are often applied in combination with systemic fungicides, the research on ecological risks of neonicotinoids has been focused on the analysis of these compounds without considering their interaction with other agrochemicals. The objective of this study was to identify the concentration of thiamethoxam and mefenoxam in soybean flowers and …
The Measles Vaccine, Ben Albrecht
The Measles Vaccine, Ben Albrecht
A with Honors Projects
This honors project reviews the development of the measles vaccine, and the controversial and debunked research that led to a decrease in vaccinations and an increase in the illness.
Herbal Supplements: Perceptions, Risks And Need For Improved Regulation, Julia Nikati Wright
Herbal Supplements: Perceptions, Risks And Need For Improved Regulation, Julia Nikati Wright
Senior Projects Fall 2019
Herbal supplements have become widely used in the United States to treat a variety of ailments. Though the market for these supplements have grown since the passage of the 1994 Dietary Supplements Health and Education Act, the FDA has failed to expand its regulation over these products. Herbal supplements in the United States have been found to be contaminated, misbranded, and sold at unsafe doses. These issues can seriously affect the health and safety of consumers. The issue with the quality of these products is coupled with the lack of knowledge about herbal supplements. Scientific research is severely lacking when …
The Effects Of Bisphenol F On Embryonic Cardiac Output In Zebrafish, Kyle Monnot
The Effects Of Bisphenol F On Embryonic Cardiac Output In Zebrafish, Kyle Monnot
Williams Honors College, Honors Research Projects
Bisphenol F (BPF) is an analog compound of the xenoestrogen bisphenol A (BPA). BPA utilization has decreased dramatically due to its detrimental effects as an endocrine disrupter. In place of BPA, BPF is growing to be a ubiquitous chemical in epoxy resin manufacturing. Recent research has begun to investigate the possible endocrinal effects of BPF as an analog of BPA. This study was performed to examine the potential effects of BPF exposure on cardiac parameters of zebrafish (Danio rerio) embryos. Embryos were exposed to 50 µg/L BPF for 48 hours, and cardiac parameters (stroke volume, heart rate, and …
Applying The Concept Of Thresholds In Ecotoxicology With Focus On The Joint Effects Of Habitat Fragmentation And Contamination, Marcos Krull
Applying The Concept Of Thresholds In Ecotoxicology With Focus On The Joint Effects Of Habitat Fragmentation And Contamination, Marcos Krull
Dissertations, Theses, and Masters Projects
A threshold can be defined as the point where small changes in an environmental driver produce an abrupt change within a biological system. These changes can occur at different levels of organization, from organisms to ecosystems. Although thresholds seem to be receiving more attention by ecotoxicologist, not much is known about how contaminants cause or affect thresholds at the landscape level, such as habitat fragmentation thresholds. Habitat fragmentation thresholds can occur due to rapid changes in the landscape structure after a certain amount of habitat is lost, which can cause abrupt effects on the movement of organisms, population abundance and …