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Articles 1 - 5 of 5
Full-Text Articles in Other Pharmacology, Toxicology and Environmental Health
The Effects Of Maternal Delta-9-Tetrahydrocannabinol And Cannabidiol Exposure On Fetal Heart Development In Mice, Gregory Robinson
The Effects Of Maternal Delta-9-Tetrahydrocannabinol And Cannabidiol Exposure On Fetal Heart Development In Mice, Gregory Robinson
Electronic Thesis and Dissertation Repository
Up to 22.6% of pregnant women consume cannabis during pregnancy despite the uncertainty of teratogenicity of the main ingredients in cannabis, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). This study tested the hypothesis that gestational THC and CBD exposure leads to heart abnormalities. Daily, oral THC exposure induced heart abnormalities in 68% of offspring with three main phenotypes including thickened semilunar valves, ventricular myocardial hypertrophy and hypoplastic coronary arteries in fetuses, and postnatal cardiac dysfunction. Altered gene expression of key cardiogenic regulators, increased proliferation, and reduced epicardial epithelial-to-mesenchymal-transition were demonstrated implicating potential mechanisms responsible for these abnormalities. Also, maternal CBD exposure resulted …
Understanding Neonicotinoid Related Immunosuppression: A Potential For Beneficial Bacterial Intervention, John A. Chmiel
Understanding Neonicotinoid Related Immunosuppression: A Potential For Beneficial Bacterial Intervention, John A. Chmiel
Electronic Thesis and Dissertation Repository
The use of neonicotinoid pesticides has been implicated in the recent decrease of honey bee (Apis mellifera) populations. In this thesis, a Drosophila melanogaster model was used to characterize immune impairment associated with imidacloprid (neonicotinoid) exposure and test the ability of beneficial bacteria (lactobacilli) to alleviate these harmful effects. The experiments outlined in chapters 2 and 3 demonstrate that imidacloprid alters the gut microbiota by exploiting the cooperation between gut immune pathways. The pesticide reduces expression of Duox via dysregulation of the immune deficiency pathway resulting in decreased hydrogen peroxide production. This contributes to the microbiota changes but …
Consequences Of Environmental Mercury Exposure For Migratory Fitness And Survival Of Passerine Birds, Yanju Ma
Consequences Of Environmental Mercury Exposure For Migratory Fitness And Survival Of Passerine Birds, Yanju Ma
Electronic Thesis and Dissertation Repository
Mercury (Hg) is a global contaminant that persists in the environment. The organic form, methylmercury (MeHg) has been shown to adversely affect bird immune function, foraging behavior, navigation, and flight ability. Many songbirds migrate seasonally, a process that consists of multiple endurance flights and refueling at stopovers. Current knowledge of the effects of MeHg on songbird migration and survival is mostly speculative. In this thesis, I present three studies of MeHg in migratory songbirds. In Chapter 2, I assessed the breeding ground MeHg exposure (inferred from feather Hg) of 15 songbird species captured during fall migration at bird banding stations …
Rxtx And Micromedex, Shawn Hendrikx, Kelly Hatch
Rxtx And Micromedex, Shawn Hendrikx, Kelly Hatch
Western Libraries Publications
No abstract provided.
Mitigation Of Pesticide Toxicity By Food-Grade Lactobacilli, Mark E. Trinder
Mitigation Of Pesticide Toxicity By Food-Grade Lactobacilli, Mark E. Trinder
Electronic Thesis and Dissertation Repository
Lactobacilli are Gram-positive bacteria used in fermented foods. Many species are commensal microbiota members that confer host benefits. This thesis investigated lactobacilli mitigation of organophosphate and neonicotinoid pesticide toxicity in mammals and insects, respectively. Lactobacillus rhamnosus GG (LGG) and GR-1 (LGR-1) were found to sequester, but not metabolize, organophosphate pesticides (parathion and chlorpyrifos) in solution. For LGG, this sequestration reduced organophosphate pesticide absorption in a Caco-2 intestinal Transwell model and promoted survival of Drosophila melanogaster lethally exposed to chlorpyrifos. Supplementation of mice with LGR-1 was found to alter host xenobiotic metabolism in the liver, and consequently chlorpyrifos metabolism following acute …