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Full-Text Articles in Other Pharmacology, Toxicology and Environmental Health
Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli
Cortisol Receptor Sensitivity As A Risk Factor For Depression, Michela Michielli
Honors Theses
In 2020, the World Health Organization reported over 264 million people across the world were suffering from depression. Studies have demonstrated that one source of depression is a hormonal imbalance involved in the stress response. Cortisol is a stress hormone regulated by the Hypothalamic-Anterior-Pituitary (HPA) Axis. Its effects on the stress response and other metabolic activities in the body are exerted through the glucocorticoid and mineralocorticoid receptors (GR and MR respectively).
Our research has examined mutations known as single-nucleotide-polymorphisms (SNPs) relating to cortisol-receptor sensitivity and the behavior of cortisol in the body to investigate the link between cortisol activity and …
Hear Me Roar, Abigail R. Seethoff
Hear Me Roar, Abigail R. Seethoff
Graduate Student Theses, Dissertations, & Professional Papers
Hear Me Roar, a compilation of personal essays interspersed with short forms, grapples with the nuances of compliance versus autonomy in the context of the male gaze, beauty standards, and pop culture. The collection also explores what it means to treasure something—another person, an object—and how to express and deepen that affection.
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley
Theses and Dissertations--Pharmacology and Nutritional Sciences
Cardiovascular disease (CVD) is the leading cause of death worldwide and is partially attributed to perturbations in lipid metabolism. Xenobiotics, such as pharmaceutical drugs and environmental chemicals, have been associated with increased risk of CVD in multiple large-scale human population studies, but the underlying mechanisms remain poorly defined. We and others have identified several xenobiotics as potent agonists for the pregnane X receptor (PXR), a nuclear receptor that can be activated by numerous drugs as well as environmental and dietary chemicals. However, the role of PXR in mediating the pathophysiological effects of xenobiotic exposure in humans and animals remains elusive. …