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Medicinal Chemistry and Pharmaceutics Commons™
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Articles 1 - 30 of 59
Full-Text Articles in Medicinal Chemistry and Pharmaceutics
Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes, Yang Peng
Theses & Dissertations
Type 1 diabetes is one of the most challenging chronic autoimmune diseases. The destruction and dysfunction of insulin-secreting β cells are the results of inflammatory infiltration and the synergistic effect of multiple immune cells. The aim of this dissertation is to develop novel and reliable therapeutic approaches to advance the treatment of T1D: including chemical modification of a broad-spectrum immunosuppressant, co-application of small molecule based immune intervention and siRNA based β cell preservative therapy, and administration of a PI3K-δ/γ dual inhibitor to specifically target immune cells, utilizing synthetic polymeric micelles or natural produced multi-functional exosomes derived from human bone marrow …
Computational Studies And Design Of Pparγ And Glut1 Inhibitors, Suliman Almahmoud
Computational Studies And Design Of Pparγ And Glut1 Inhibitors, Suliman Almahmoud
Theses & Dissertations
The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity. PPARγ is a target for insulin-sensitizing drugs, and it plays a significant function in prostate cancer. PPARγ antagonists have anti-proliferative effects in a broad range of hematopoietic and epithelial cell lines. The ligand binding domain (LBD) of PPARγ is large and has orthosteric and allosteric binding sites. Several PPARγ-ligand co-crystal structures show two bound molecules, one to the orthosteric pocket and a second to the allosteric …
Sustainable Solutions, Fall/Winter 2020, Issue 41
Sustainable Solutions, Fall/Winter 2020, Issue 41
Sustain Magazine
No abstract provided.
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22
Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22
Sustain Magazine
No abstract provided.
Sustainable Communities, Fall/Winter 2010, Issue 21
Sustainable Communities, Fall/Winter 2010, Issue 21
Sustain Magazine
No abstract provided.
Sustainable Building, Spring/Summer 2009, Issue 20
Sustainable Building, Spring/Summer 2009, Issue 20
Sustain Magazine
No abstract provided.
Environmental History, Fall/Winter 2009, Issue 19
Environmental History, Fall/Winter 2009, Issue 19
Sustain Magazine
No abstract provided.
Student Research, Spring/Summer 2008, Issue 18
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17
Evolving Pollution Prevention, Fall/Winter 2008, Issue 17
Sustain Magazine
No abstract provided.
Climate Change, Spring/Summer 2007, Issue 16
Our Energy Future, Fall/Winter 2007, Issue 15
Land Conservation, Spring/Summer 2006, Issue 14
Land Conservation, Spring/Summer 2006, Issue 14
Sustain Magazine
No abstract provided.
Pollution And Heart Disease, Fall/Winter 2006, Issue 13
Pollution And Heart Disease, Fall/Winter 2006, Issue 13
Sustain Magazine
No abstract provided.
Green Cities, Spring/Summer 2005, Issue 12
Global Sustainability, Fall/Winter 2005, Issue 11
Global Sustainability, Fall/Winter 2005, Issue 11
Sustain Magazine
No abstract provided.
Environmental Justice, Spring/Summer 2004, Issue 10
Environmental Justice, Spring/Summer 2004, Issue 10
Sustain Magazine
No abstract provided.
Kentucky's Environmental Future, Fall/Winter 2004, Issue 9
Kentucky's Environmental Future, Fall/Winter 2004, Issue 9
Sustain Magazine
No abstract provided.
Urban Ecology, Spring/Summer 2003, Issue 8
Urban Regeneration, Fall/Winter 2003, Issue 7
Urban Air Quality, Spring/Summer 2002, Issue 6
Sustainability Of Industrialized Agriculture, Fall/Winter 2002, Issue 5
Sustainability Of Industrialized Agriculture, Fall/Winter 2002, Issue 5
Sustain Magazine
No abstract provided.
Urban Design For Environmental Protection, Spring/Summer 2001, Issue 4
Urban Design For Environmental Protection, Spring/Summer 2001, Issue 4
Sustain Magazine
No abstract provided.
Stream Restoration, Spring/Summer 2011, Issue 24
Stream Restoration, Spring/Summer 2011, Issue 24
Sustain Magazine
No abstract provided.
Renewable Energy, Fall/Winter 2011, Issue 23
Biodiversity, Fall/Winter 2012, Issue 25
Active Transportation, Spring/Summer 2012, Issue 26
Active Transportation, Spring/Summer 2012, Issue 26
Sustain Magazine
No abstract provided.
Heat Islands, Fall/Winter 2014, Issue 29
Sustainable Behavior, Spring/Summer 2013, Issue 28
Sustainable Behavior, Spring/Summer 2013, Issue 28
Sustain Magazine
No abstract provided.
Local Foods, Fall/Winter 2013, Issue 27
Campus Sustainability, Spring/Summer 2014, Issue 30
Campus Sustainability, Spring/Summer 2014, Issue 30
Sustain Magazine
No abstract provided.