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Maternal Serum Polychlorinated Biphenyl Concentrations Across Critical Windows Of Human Development, Michael S. Bloom, Germaine M. Buck-Louis, Aiyi Liu
Maternal Serum Polychlorinated Biphenyl Concentrations Across Critical Windows Of Human Development, Michael S. Bloom, Germaine M. Buck-Louis, Aiyi Liu
Environmental Health Sciences Faculty Scholarship
Background
Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window.
Objectives
Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant.
Methods
Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n= 10), at approximately …