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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul
387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul
HPD Articles
The deposition of amyloid β-peptides (Aβ), cleavage products of the amyloid precursor protein (APP) by β- and γ-secretases, in brain represents a pathological hallmark of Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers have an increased risk to develop AD and an earlier age of onset, whereas carriers of the ε2 allele have reduced risk and a delayed age of onset. APOE is also a major determinant of brain Aβ and amyloid burden in humans and in several transgenic mouse models of AD (E4>E3>E2). We have previously reported that lentivirus-mediated intraparenchymal gene delivery of APOE2 significantly reduces …
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix F. Gene Ontology Maps, Trevor Fish, Abby Benninghoff
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix F. Gene Ontology Maps, Trevor Fish, Abby Benninghoff
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This archive includes 10 individual image files, each of which depicts a Gene Ontolgoy map for GO terms representing hypermethylated gene promoters unique for the indicated tissue(s) (listed first in file name) compared to other tissues (listed in parentheses in file name).
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix B. Nimblegen Processed Data Report For Nearest Methylated Peaks, Trevor Fish, Abby Benninghoff
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix B. Nimblegen Processed Data Report For Nearest Methylated Peaks, Trevor Fish, Abby Benninghoff
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No abstract provided.
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix D. Gene Lists For Ontology Analysis, Trevor Fish, Abby Benninghoff
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix D. Gene Lists For Ontology Analysis, Trevor Fish, Abby Benninghoff
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No abstract provided.
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix C. Peak Scores Summary Table For All Methylated Genes In Any Data Set, Trevor Fish, Abby Benninghoff
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix C. Peak Scores Summary Table For All Methylated Genes In Any Data Set, Trevor Fish, Abby Benninghoff
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No abstract provided.
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix A. Nimblegen Processed Data Report For All Methylated Peaks, Trevor Fish, Abby Benninghoff
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix A. Nimblegen Processed Data Report For All Methylated Peaks, Trevor Fish, Abby Benninghoff
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No abstract provided.