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Pharmacology, Toxicology and Environmental Health Commons™

Open Access. Powered by Scholars. Published by Universities.®

2014

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Articles 151 - 180 of 186

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

The Environmental, Social, And Economic Impacts Of Hydraulic Fracturing, Horizontal Drilling, And Acidization In California, Christina Whalen Jan 2014

The Environmental, Social, And Economic Impacts Of Hydraulic Fracturing, Horizontal Drilling, And Acidization In California, Christina Whalen

CMC Senior Theses

The oil extraction mechanisms of hydraulic fracturing, horizontal drilling, and acidization have recently spread throughout the state of California. This thesis explores and assesses whether federal and state legislation should approve of fracking operations in California after studying its effects on human health, the environment, and the economy. This thesis assesses the impacts of fracking; analyzes the role of current legislation and regulation; compares California fracking to fracking in other states and countries; and provides recommendations for future action.

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Effects Of Anti-Inflammatory Foods On Hyperglycemia In Type-1 Diabetics, Primrose Martin, Michelle Chino Jan 2014

Effects Of Anti-Inflammatory Foods On Hyperglycemia In Type-1 Diabetics, Primrose Martin, Michelle Chino

McNair Poster Presentations

Based on a case study administered by Dr. Charlotte Gerson, an IDDM patient referred to as R.H. reversed hyperglycemic symptoms within ten weeks while adhering to a diet of mainly vegetables and some low-glycemic index fruits. R.H. also ingested mineral supplements and underwent multiple coffee enemas each day (Gerson & Bishop, 2007, p. 56). This self-study hypothesizes that diet alone has a positive correlation coefficient with hyperglycemic blood glucose levels in type-1 diabetics (IDDM). Conducting this self-study contributes information to the limited research and database of alternative methods for managing IDDM hyperglycemia, and provides candid documentation of the effects that …

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Epoxy Resin Monomers With Reduced Skin Sensitizing Potency, Niamh F. O'Boyle, Ida B. Niklasson, Ali R. Tehrani-Bagda, Tamara Delaine, Krister Holmberg, Kristina Luthman, Ann-Therese Karlberg Jan 2014

Epoxy Resin Monomers With Reduced Skin Sensitizing Potency, Niamh F. O'Boyle, Ida B. Niklasson, Ali R. Tehrani-Bagda, Tamara Delaine, Krister Holmberg, Kristina Luthman, Ann-Therese Karlberg

Articles

Epoxy resin monomers, including diglycidyl ethers of bisphenol A and F (DGEBA and DGEBF), are extensively used as building blocks for thermosetting polymers. However, they are known to cause widespread contact allergy. This research describes a number of alternative epoxy resin monomers, designed with the aim of reducing the skin sensitizing potency whilst maintaining the ability to form thermosetting polymers. The compounds were designed, synthesized, assessed for skin sensitizing potency using the in vivo murine local lymph node assay, and tested for technical applicability using thermogravimetric analysis and differential scanning calorimetry. All the novel epoxy resin monomers had decreased skin …

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Addressing Public Health Risks Of Persistent Pollutants Through Nutritional Modulation And Biomimetic Nanocomposite Remediation Platforms, Bradley J. Newsome Jan 2014

Addressing Public Health Risks Of Persistent Pollutants Through Nutritional Modulation And Biomimetic Nanocomposite Remediation Platforms, Bradley J. Newsome

Theses and Dissertations--Chemistry

Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) pose significant health risks and enduring remediation challenges. Engineered nanoparticles (NPs) provide a novel platform for sensing/remediation of these toxicants, in addition to the growing use of NPs in many industrial and biomedical applications, but there remains concern for their potential long-term health effects. Research highlighted herein also represents a transdisciplinary approach to address human health challenges associated with exposure to PCBs and NPs. The objectives of this dissertation research are two-fold, 1) to develop effective methods for capture/sensing and remediation …

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Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation, Usa Suwannasual, Thitima Pengsuparp, Rataya Luechapudiporn Jan 2014

Protective Effect Of Deferiprone On 7-Ketocholesterol Formation In Hemin-Induced Ldl Oxidation, Usa Suwannasual, Thitima Pengsuparp, Rataya Luechapudiporn

The Thai Journal of Pharmaceutical Sciences

Hemin (iron (III)-protoporphyrin IX) is found that it is elevated in the plasma of thalassemic patients and is a possible cause of oxidative stress-promoting atherosclerosis. Deferiprone (L1), an iron chelator, can prevent free radical formation catalyze...

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Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine, Kulwadee Sawatpaiboontawee, Panutsaya Sermthaveesub, Panuwat Sangsirimongkolying, Patratorn Kunakorntham, Sudarat Thongborriboon, Bodin Tuesuwan, Vorasit Vongsutilers Jan 2014

Development And Validation Of Rp-Hplc Method For Analysis And Stability Study Of 8-Carboxyphenyl-2'-Deoxyguanosine And 8-Bromo-2'-Deoxyguanosine, Kulwadee Sawatpaiboontawee, Panutsaya Sermthaveesub, Panuwat Sangsirimongkolying, Patratorn Kunakorntham, Sudarat Thongborriboon, Bodin Tuesuwan, Vorasit Vongsutilers

The Thai Journal of Pharmaceutical Sciences

Modifications on C8 position of purine base have been studied for their effects on B-DNA to Z-DNA conversion. The 8-bromo and 8-carboxyphenyl adduct are among the most potent Z-DNA facil tators and hence arc aimed to be utilized for Z-DNA based probe lor...

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Federal V. State Effectiveness: An Analysis Of The Endangered Species Act And Current Potential Attempts At Reform, Nicholas Primo Jan 2014

Federal V. State Effectiveness: An Analysis Of The Endangered Species Act And Current Potential Attempts At Reform, Nicholas Primo

Pepperdine Policy Review

In November 2013, several Congressional leaders drafted a new bill to reform the Endangered Species Act of 1973 (ESA). While the Endangered Species Management Self-Determination Act (ESMSDA) was the first major attempt at updating the crucial U.S. environmental policy in decades, it also inflamed environmentalist defenders of the original bill. More importantly, it raised several questions as to whether state or federal-oriented approaches to endangered species protection and environmental policy more broadly is ultimately more effective. This article analyzes the original 1973 ESA, followed by an analysis of the ESMSDA currently being considered. It will discuss the various strengths and …

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Non-Additive Toxicity Of Bi-Metal Mixtures To Fathead Minnows, Natalie Rae Lynch Jan 2014

Non-Additive Toxicity Of Bi-Metal Mixtures To Fathead Minnows, Natalie Rae Lynch

Master's Theses

Much research has been conducted to assess the toxicity of metals to aquatic organisms. Most of the research has focused on the toxicity of individual metals. Recently, attention has been paid to metal mixture toxicity because metals are usually present as mixtures in contaminated environments. The literature review indicates that metal mixtures may be additive, synergistic, or antagonistic to freshwater species. However, the data is not consistent and is dependent on the metal and organisms. The goal of this research is to use a systematic experimental design to characterize the toxicity of Cu, Zn, Cd and Ni mixtures to Pimephales …

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Comparative Study Of Postmortem Blood, Urine And Vitreous Humor Methamphetamine, Rungtip Narapanyakul, Wichian Tungtananuwat, Patramon Yongpanich, Theerin Sinchai, Nantana Thong-Ra-Ar, Somsong Lawanprasert Jan 2014

Comparative Study Of Postmortem Blood, Urine And Vitreous Humor Methamphetamine, Rungtip Narapanyakul, Wichian Tungtananuwat, Patramon Yongpanich, Theerin Sinchai, Nantana Thong-Ra-Ar, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Methamphetamine (MA) is a highly addictive and toxic central nervous system stimulant. Urine samples are used as evidences of MA abuse under the Narcotics Laws, whereas blood samples are specimens for investigation of MA poisoning. However, both specimen...

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Evaluation Of Antioxidant And Free Radical Scavenging Activities Of Different Fractions Of Pterospermum Suberifolium Leaf Extract, Dibyajyoti Saha, Swati Paul Jan 2014

Evaluation Of Antioxidant And Free Radical Scavenging Activities Of Different Fractions Of Pterospermum Suberifolium Leaf Extract, Dibyajyoti Saha, Swati Paul

The Thai Journal of Pharmaceutical Sciences

The study was aimed an evaluating the antioxidant activities of the various leaf extracts (ethyl acetate, n- butanol and chloroform) of Pterospermum suberifolium by using various in vitro antioxidant assays. The total polyphenols were also determined spe...

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Determination Of Retinol And Alpha-Tocopherol In Avocado Nanoemulsion With Monolithic Column, Wisanu Thongchai Jan 2014

Determination Of Retinol And Alpha-Tocopherol In Avocado Nanoemulsion With Monolithic Column, Wisanu Thongchai

The Thai Journal of Pharmaceutical Sciences

A high performance liquid chromatographic procedure was developed for separation of retinol and a-tocopherol from avocado oil. The extraction methods were studied to extract of oil from avocado sample. This method was developed and validated for various ...

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A New Rp-Hplc Method For Estimation Of Clindamycin And Adapalene In Gel Formulation: Development And Validation Consideration, Rohit. H. Khatri, Rashmin. B. Patel, Mrunali R. Patel Jan 2014

A New Rp-Hplc Method For Estimation Of Clindamycin And Adapalene In Gel Formulation: Development And Validation Consideration, Rohit. H. Khatri, Rashmin. B. Patel, Mrunali R. Patel

The Thai Journal of Pharmaceutical Sciences

This paper describes a validated high-performance liquid chromatographic (HPLC) method for simultaneous estimation of clindamycin (CLI) and adapalene (ADA) in pure powder and gel formulation. The HPLC separation was achieved on a Luna C18 (2) (250 x 4.6 ...

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Verification Of Using Saliva As An Alternative To Serum For Topiramate Monitoring, Jareerut Kongrit, Yotin Chinvarun, Nuansri Niwattisaiwong, Somsong Lawanprasert Jan 2014

Verification Of Using Saliva As An Alternative To Serum For Topiramate Monitoring, Jareerut Kongrit, Yotin Chinvarun, Nuansri Niwattisaiwong, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

This study aims to verify the correlation between serum and saliva topiramate concentrations in Thai patients with epilepsy. Twenty-six subjects were patients aged 17-56 years old who were under treatment with topiramate. Their blood and saliva samples w...

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Authentication Of A Thai Crude Drug "Kot-Chula-Lumpa" Using Gas Chromatography-Mass Spectrometry And Multivariate Data Analysis, Jankana Burana-Osot, Panadda Phattanawasin, Sununta Srisopon, Praveen Kumar Ashok, Baokang Huang, Uthai Sotanaphun Jan 2014

Authentication Of A Thai Crude Drug "Kot-Chula-Lumpa" Using Gas Chromatography-Mass Spectrometry And Multivariate Data Analysis, Jankana Burana-Osot, Panadda Phattanawasin, Sununta Srisopon, Praveen Kumar Ashok, Baokang Huang, Uthai Sotanaphun

The Thai Journal of Pharmaceutical Sciences

Kot-chula-lumpa is a crude drug of Thai traditional medicine for fever remedy. To authenticate its botanical origin, gas chromatogram of its non-polar constituents was analysed and compared with those of authentic samples by using chemometric tools. Fing...

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Association Of Genetic Variants In Ugt1a6 Genes And Non-Genetic Variant With Valproic Acid Doses And Plasma Concentration In Thai Epileptic Patients, Salinthip Aphichartphunkawee, Yotin Chinvarun, Pornpimol Kijsanayotin Jan 2014

Association Of Genetic Variants In Ugt1a6 Genes And Non-Genetic Variant With Valproic Acid Doses And Plasma Concentration In Thai Epileptic Patients, Salinthip Aphichartphunkawee, Yotin Chinvarun, Pornpimol Kijsanayotin

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to investigate the association of genetic variants in UGT1A6 19T>G, 541A>G and 552A>C together with non-genetic variant with VPA dose and plasma concentrations in Thai epileptic patients. Eighty four Thai epileptic patients who ...

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Dissolution Enhancement Of Dronedarone Hydrochloride By Complexation With Ss-Cd And Hp Ss-Cd: Dissolution And Physicochemical Characterization, Anjan Kumar Mahapatra, Supriya Samoju, Ruchita Kumari Patra, Padala Narasimha Murthy Jan 2014

Dissolution Enhancement Of Dronedarone Hydrochloride By Complexation With Ss-Cd And Hp Ss-Cd: Dissolution And Physicochemical Characterization, Anjan Kumar Mahapatra, Supriya Samoju, Ruchita Kumari Patra, Padala Narasimha Murthy

The Thai Journal of Pharmaceutical Sciences

The study was aimed to improve solubility or dissolution characteristics of dronedarone hydrochloride by preparing its inclusion complexes (ICs) with ß-cyclodextrin (ß-CD) and hydroxypropyl ß-cyclodextrin (HP ß-CD). The phase solubility behavior of d...

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Plant Produced Therapies For Ebola Infection, Waranyoo Phoolcharoen, Matthew Paul Jan 2014

Plant Produced Therapies For Ebola Infection, Waranyoo Phoolcharoen, Matthew Paul

The Thai Journal of Pharmaceutical Sciences

Ebola virus (EBOV) causes severe haemorrhagic fever in humans with high fatality rate up to 90 %. There is currently no approved drug or vaccine for human use. and treatment relies almost exclusively co supportive therapy. However, there are several pote...

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Bioequivalence Study Of Abacavir 300 Mg Tablets In Healthy Thai Male Volunteers Under Fasting Conditions, Isariya Techatanawat, Chutima Manamuti, Jaturavit Vattanarongkup, Polsak Teerawonganan, Ekawan Yoosakul, Wiwat Supasena, Bancha Chuasuwan, Piengthong Narakorn, Ponanee Puranaoti Jan 2014

Bioequivalence Study Of Abacavir 300 Mg Tablets In Healthy Thai Male Volunteers Under Fasting Conditions, Isariya Techatanawat, Chutima Manamuti, Jaturavit Vattanarongkup, Polsak Teerawonganan, Ekawan Yoosakul, Wiwat Supasena, Bancha Chuasuwan, Piengthong Narakorn, Ponanee Puranaoti

The Thai Journal of Pharmaceutical Sciences

Abacavir is an antiretroviral drug that can be prescribed in single dose or in fixed-dose combination formulations to make adherence easier. Due to this advantage, a generic product of abacavir of GPO has been developed with lower price and would be bene...

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Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration, Rashmin. B. Patel, Mrunali. R. Patel, Tapan S. Goswami Jan 2014

Stability Indicating Rp-Hplc Method For Estimation Of Bamifylline Hydrochloride In Tablet Formulation: Development And Validation Consideration, Rashmin. B. Patel, Mrunali. R. Patel, Tapan S. Goswami

The Thai Journal of Pharmaceutical Sciences

A simple, specific and robust stability indicating high performance liquid chromatographic (HPLC) method for estimation of bamifylline hydrochloride was developed and validated. Bamifylline hydrochloride was separated and quantitated on Inertsil ODS-3V c...

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Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases, Sirirat Phomhitatorn, Theerin Sinchai, Nantana Thongra-Ar, Somsong Lawanprasert Jan 2014

Relationship Between Methamphetamine Concentrations In Hair Root, Blood And Urine Samples In Postmortem Cases, Sirirat Phomhitatorn, Theerin Sinchai, Nantana Thongra-Ar, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Urine and blood samples are normally used to determine methamphetamine (MA) level in forensic and clinical toxicology for assessment of illicit MA use. In cases in which both samples are unavailable or contaminated, hair root has been proposed as an alte...

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Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy, Sunisa Deeoun, Pravaree Phuneerub, Chanida Palanuvej, Nijsiri Ruangrungsi, Pasarapa Towiwat Jan 2014

Antinociceptive And Anti-Inflammatory Activities Of Tree-Phon-Thad Remedy, Sunisa Deeoun, Pravaree Phuneerub, Chanida Palanuvej, Nijsiri Ruangrungsi, Pasarapa Towiwat

The Thai Journal of Pharmaceutical Sciences

Tree-Phon-Thad remedy is used as an antipyretic and anti-inflammatory agent by traditional practitioners in Thailand, and includes roots of Zingiber zerumbet (Kra-Thue), Zingiber montamum (Plai) and Cymbopogon nadus (Ta-Krai-Hom). In this study, the anti...

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Acute Effects Of Hot Red Chili On Autonomic And Metabolic Functions In Healthy Subjects, Kannikar Chatsantiprapa, Cameron Hurst, Kaewjai Thepsuthammarat, Nutcharee Thapunkaw, Wilaiwan Khrisanapant Jan 2014

Acute Effects Of Hot Red Chili On Autonomic And Metabolic Functions In Healthy Subjects, Kannikar Chatsantiprapa, Cameron Hurst, Kaewjai Thepsuthammarat, Nutcharee Thapunkaw, Wilaiwan Khrisanapant

The Thai Journal of Pharmaceutical Sciences

To investigate if chili consumption as a food ingredient in a fried rice meal would have any real acute pharmacological effects on autonomic nervous system (ANS) and metabolic system (MS), a randomized, cross-over, intervention trial was conducted in 33 ...

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Short-Term Safety And Efficacy Of Fish-Oil Emulsions On The Prevention Of Parenteral Nutrition-Associated Liver Disease In Surgical Neonates: A Randomized Controlled Trial, Jrarat Ariyawangso, Chankit Puttilerpong, Suntaree Ratanachu-Ek, Maitree Anuntkosol Jan 2014

Short-Term Safety And Efficacy Of Fish-Oil Emulsions On The Prevention Of Parenteral Nutrition-Associated Liver Disease In Surgical Neonates: A Randomized Controlled Trial, Jrarat Ariyawangso, Chankit Puttilerpong, Suntaree Ratanachu-Ek, Maitree Anuntkosol

The Thai Journal of Pharmaceutical Sciences

Surgical neonates requiring prolonged parenteral nutrition (PN) are at risk for parenteral nutrition-associated liver disease (PNALD) that contributes to an increase in morbidity and mortality in surgical infants. Current lipid emulsions used with neonat...

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Evaluation Of Analgesic Activity Of Hydroalcoholic Extract Of Ipomoea Staphylina, Soumyadeep Ghosh, M Firdous Jan 2014

Evaluation Of Analgesic Activity Of Hydroalcoholic Extract Of Ipomoea Staphylina, Soumyadeep Ghosh, M Firdous

The Thai Journal of Pharmaceutical Sciences

This study has been attempted to evaluate analgesic property of hydroalcoholic extract of leaves of Ipomoea staphylina. Analgesic activity was evaluated by abdominal writhing, formalin-induced paw licking method and Eddy's hot plate test in mice. The hyd...

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Molecular Binding Modes Of Diarylheptanoids From Curcuma Comosa On The Er-Ss Receptor, Nathjanan Jongkon, Prasan Tangyuenyongwatana Jan 2014

Molecular Binding Modes Of Diarylheptanoids From Curcuma Comosa On The Er-Ss Receptor, Nathjanan Jongkon, Prasan Tangyuenyongwatana

The Thai Journal of Pharmaceutical Sciences

Curcuma comosa Roxb. is a medicinal plant that belongs to the Zingiberaceae family. The plant has been used in traditional Thai medicine for the treatment of postpartum uterine bleeding. The major compounds found in this plant are diarylheptanoids, which...

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Development And Evaluation Of Transdermal Patches Of Aceclofenac, Animesh Gairola, Urmi Chaurasia, Anupama Singh, Vikas Anand Saharan Jan 2014

Development And Evaluation Of Transdermal Patches Of Aceclofenac, Animesh Gairola, Urmi Chaurasia, Anupama Singh, Vikas Anand Saharan

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to develop and evaluate matrix-type transdermal therapeutic system containing aceclofenac with different ratios of hydrophilic polymers (hydroxylpropyl methylcellulose, sodium carboxy methylcellulose) and a hydrophobic polymer (...

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Synthesis And Biological Screening Of Some Thienyl And Phenyl Pyrazoline Derivatives As Antimalarial Agent, Abdu Tuha, Adnan A. Bekhit, Yimer Seid Jan 2014

Synthesis And Biological Screening Of Some Thienyl And Phenyl Pyrazoline Derivatives As Antimalarial Agent, Abdu Tuha, Adnan A. Bekhit, Yimer Seid

The Thai Journal of Pharmaceutical Sciences

Malaria is a common parasitic disease of the developing world and drug resistance has hindered their efficient control. Pyrazole derivatives were synthesized using aldol condensation and subsequent cyclization reactions. The compounds were synthesized in...

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In Silico Prediction Of Interaction Between Flavonoids Of Propolis Of Honey Bee And Anthrax Protective Antigen, Shahin Gavanji, Mohsen Doostmohammadi, Behrouz Larki Jan 2014

In Silico Prediction Of Interaction Between Flavonoids Of Propolis Of Honey Bee And Anthrax Protective Antigen, Shahin Gavanji, Mohsen Doostmohammadi, Behrouz Larki

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to check the interaction between four ligands (Acacetin, Chrysin, Naringenin and Caffeic Acid Phenethyl Ester) and protective antigen. These ligands are the main flavonoids of propolis of honey. Bioinformatics checking was done ...

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Concern-Driven Integrated Toxicity Testing Strategies For Nanomaterials - Report Of The Nanosafety Cluster Working Group 10, Hugh Byrne, Agnes G. Oomen, Peter M.J. Bos, Teresa F. Fernandes, Kerstin Hund-Rinke, Diana Boraschi, Karin Aschberger, Stefania Gottardo, Frank Von Der Kammer, Dana Kühnel, Danail Hristozov, Antonio Marcomini, Lucia Migliore Jan 2014

Concern-Driven Integrated Toxicity Testing Strategies For Nanomaterials - Report Of The Nanosafety Cluster Working Group 10, Hugh Byrne, Agnes G. Oomen, Peter M.J. Bos, Teresa F. Fernandes, Kerstin Hund-Rinke, Diana Boraschi, Karin Aschberger, Stefania Gottardo, Frank Von Der Kammer, Dana Kühnel, Danail Hristozov, Antonio Marcomini, Lucia Migliore

Articles

Bringing together topic-related European Union-(EU)-funded projects, the so-called “NanoSafety Cluster” aims at identifying key areas for further research on risk assessment procedures for nanomaterials (NM). The outcome of NanoSafety Cluster Working Group 10, this commentary presents a vision for concern-driven integrated approaches for the (eco-)toxicological testing and assessment (IATA) of NM. Such approaches should start out by determining concerns, i.e. specific information needs for a given NM based on realistic exposure scenarios. Recognized concerns can be addressed in a set of tiers using standardized protocols for NM preparation and testing. Tier 1 includes determining physico-chemical properties, non-testing (e.g. structure …

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Novel Compounds As Potential Alzheimer's Disease Therapeutics And Inhibitors Of The Nlrp3 Inflammasome, Jeremy E. Chojnacki Jan 2014

Novel Compounds As Potential Alzheimer's Disease Therapeutics And Inhibitors Of The Nlrp3 Inflammasome, Jeremy E. Chojnacki

Theses and Dissertations

Alzheimer’s disease is a devastating neurodegenerative disorder and the leading cause of dementia. The disease manifests via several pathologies including neuroinflammation, oxidative stress, metal ion dyshomeostasis, and cell death. To address the multifaceted nature of this disorder, the design of several diverse compounds, targeting many pathological effects, was generated. First, a series of compounds based on curcumin and diosgenin were synthesized following the bivalent design strategy. Two compounds were discovered to have neuroprotective ability, anti-oxidative function, and anti-Aß oligomerization (AßO) properties. A second set of molecules was also designed, wherein a hybrid compound strategy was utilized. Three hybrids were to …

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