Pharmacology, Toxicology and Environmental Health Commons^™

Diet-Induced Obesity: Dopaminergic And Behavioral Mechanisms As Outcomes And Predictors, Vidya Narayanaswami

Theses and Dissertations--Pharmacy

Obesity and drug abuse share common neural circuitries including the mesocoticolimbic and striatal dopamine reward system. In the current study, a rat model of diet-induced obesity (DIO) was used to determine striatal dopamine function, impulsivity and motivation as neurobehavioral outcomes and predictors of obesity. For the outcome study, rats were randomly assigned a high-fat (HF) or a low-fat (LF) diet for 8 wk. Following the 8-wk HF-diet exposure, rats were segregated into obesity-prone and obesity-resistant groups based on maximum and minimum body weight gain, respectively, and neurobehavioral outcomes were evaluated. For the predictor study, neurobehavioral antecedents were evaluated prior to …

Regulation Of 7-Dehydrocholesterol Reductase By Vitamin D3, Ling Zou

Theses and Dissertations--Pharmacy

7-Dehydrocholesterol (7-DHC) is the substrate of 7-dehydrocholesterol reductase (DHCR7) in the cholesterol synthesis pathway. Keratinocytes in human skin possess the enzymes necessary for cholesterol synthesis but are also responsible for vitamin D₃ synthesis from 7-DHC by exposure to UVB irradiation. It has been well established that DHCR7 is regulated by the SREBP pathway in the regulation of cholesterol synthesis, but little is known about the regulation of DHCR7 by the vitamin D pathway. In this study, the regulation of DHCR7 activity by vitamin D was explored. Treatment of adult human epidermal keratinocyte (HEKa) cells with vitamin D₃ resulted …

Methylphenidate And Atomoxetine Treatment During Adolescence In The Spontaneously Hypertensive Rat: Mechanisms Underlying High Cocaine Abuse Liability In Attention Deficit/Hyperactivity Disorder, Sucharita S. Somkuwar

Theses and Dissertations--Pharmacy

Effects of pharmacotherapies for Attention Deficit/Hyperactivity Disorder (ADHD) on cocaine abuse liability in ADHD are not understood. Spontaneously Hypertensive Rats (SHR), an ADHD model, exhibited greater cocaine self-administration than control Wistar-Kyoto and Wistar rats. Methylphenidate, but not atomoxetine during adolescence enhanced cocaine self-administration in adult SHRs compared to controls. The mesocortical dopaminergic system, including medial prefrontal (mPFC) and orbitofrontal (OFC) cortices, is important for ADHD and cocaine addiction. Dopamine and norepinephrine transporter (DAT and NET) are molecular targets for methylphenidate, atomoxetine and cocaine action.

In the current studies, SHR, Wistar-Kyoto and Wistar were administered methylphenidate (1.5 mg/kg/day, p.o.), atomoxetine (0.3 …

Environmental, Human And Socioeconomic Characteristics Of Pedestrian Injury And Death In Las Vegas, Nv, Jennifer Renee Pharr, Courtney Coughenour, Timothy J. Bungum

Environmental & Global Health Faculty Research

Background: Pedestrian crashes are a deterrent to physical activity, especially walking. The purpose of this study was to analyze pedestrian crash characteristics in Clark County, NV and to determine if there was a significant relationship between pedestrian crashes and socio-economic variables.

Methods: Police reported pedestrian crash data collected between January 2009 and December 2011 were analyzed. Frequencies and rates for pedestrian crashes, injuries and deaths were calculated for environmental and human characteristics. Chi square tests were utilized to determine if there were significant differences in environmental and human characteristics for pedestrian injuries and deaths. Zero-inflated negative binomial (ZINB) regression analysis …

Synthesis And Biochemical Activities Of Antiproliferative Amino Acid And Phosphate Derivatives Of Microtubule-Disrupting Beta-Lactam Combretastatins, Niamh M. O'Boyle, Lisa M. Greene, Niall O. Keely, Shu Wang, Tadhg S. Cotter, Daniela M. Zisterer, Mary J. Meegan

Articles

The synthesis and biochemical activities of novel water-soluble β-lactam analogues of combretastatin A-4 are described. The first series of compounds investigated, β-lactam phosphate esters 7a, 8a and 9a, exhibited potent antiproliferative activity and caused microtubule disruption in human breast carcinoma-derived MCF-7 cells. They did not inhibit tubulin polymerisation in vitro, indicating that biotransformation was necessary for their antiproliferative and tubulin binding effects in MCF-7 cells. The second series of compounds, β-lactam amino acid amides (including 10k and 11l) displayed potent antiproliferative activity in MCF-7 cells, disrupted microtubules in MCF-7 cells and also inhibited the polymerisation of …

Novel Cis-Restricted Β-Lactam Combretastatin A-4 Analogues Display Anti-Vascular And Anti-Metastatic Properties In Vitro, Seema M. Nathwani, Lisa M. Greene, Linda Hughes, Miriam Carr, Niamh O'Boyle, Susan Mcdonnell, Mary J. Meegan, Daniela M. Zisterer

Articles

No abstract provided.

Olanzapine Sensitization And Clozapine Tolerance: From Adolescence To Adulthood In The Conditioned Avoidance Response Model, Jing Qiao, Hong Li, Ming Li

Department of Psychology: Faculty Publications

Disruption of conditioned avoidance response (CAR) in rodents is one trademark feature of many antipsychotic drugs. In adult rats, repeated olanzapine (OLZ) treatment causes an enhanced disruption of avoidance response (sensitization), whereas repeated clozapine (CLZ) treatment causes a decreased disruption (tolerance). The present study addressed (1) whether OLZ sensitization and CLZ tolerance can be induced in adolescent rats, and (2) the extent to which OLZ sensitization and CLZ tolerance induced in adolescence persists into adulthood. Male adolescent Sprague–Dawley rats (approximate postnatal days (BP) 43–47) were first treated with OLZ (1.0 or 2.0 mg/kg, subcutaneously (sc)) or CLZ (10 or 20 …

Anti-Lipase Activity Of Quercus Infectoria G.Olivier Extract, Sirinan Thubthimthed., Sarunya Laovitthayanggoon, Parkpoom Siriarchavatana, Konlawit Chaithongsri, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Antibacterial Activity Of A-Mangostin From The Pericarp Extract Of Garcinia Mangostana L. Against Drug Resistant Bacteria, Griangsak Eumkeb, Sineewan Phitaktim

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Gene Cloning And Expression Of A Triterpene Synthase From Alangium Lamarckii, Nattaon Tansakul, Pimpimon Tansakul, Wanchai De-Eknamkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Investigation On Phytochemical, Antioxidant And Cytotoxic Properties Of Momordica Cochinchinensis (Gac) Fruit Extracted By Supercritical Fluid Carbon Dioxide (Scf-Co2) Method, Prapaipat Klungsupya., Worawan Tiatragoon, Thanchanok Muangman, Jirawat. Eiamwat, Sarunya Laovitthayanggoon, Jeerayu Thongdo-A, Srisak Trangwacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Meloxicam-Loaded Ph Sensitive Polymeric Micelles: Solvents And Entrapment Methods, Thisirak Woraphatphadung, Warayuth Sajomsang, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Stability Evaluation Of A Hair Conditioner Comprising A Mixed Extract From Fruits Of Phyllanthus Emblica And Zanthoxylum Limon Ella, Sitthiphong Soradech, Buppachart Potduang, Itsara Keeta, Wanlapha Saisin, Suchipha Wannaphatchaiyong, Cholticha Niwaspragrit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pharmacokinetic And Bioequivalence Evaluation Of Two Formulations Of Levocetirizine 5 Mg In Healthy Thai Volunteers, Chutima Jantarat, Thitima Keskanokwong

The Thai Journal of Pharmaceutical Sciences

Pharmacokinetics of levoceterizine have been studied, however, obtained information was only from the Western people. เท addition, the license of this drug formulation was expired few years ago. For approval of this new generic drug, the bioequivalen...

Compulsory Licensing Of Chronic Diseases Pharmaceuticals Thailand, Sakda Thanicul, Matthew Lim Braslow

The Thai Journal of Pharmaceutical Sciences

For pharmaceutical companies, obtaining patent protection for the pharmaceuticals they develop is essential. Patent protection assures that the pharmaceutical company will have a reasonable opportunity to recoup their most likely quite heavy investment in the new drug and allow the company to control the wholesale market price of the drugs. These key intellectual property rights are truly at the heart of the internationally recognized intellectual property regime. For patent right holders in general merchandise, say an innovative paperclip or mousetrap, the absolute right of the patent holder as to the distribution and price is perfectly acceptable. Pharmaceutical patents however, with …

Detection Of Esterase Activity Converting Cytotoxic Renieramycin M To Jorunnamycin A In The Crude Enzyme Of The Nudibranch Jorunna Funebris, Dalad Waropastrakul., Khanit Suwanborirux, Wanchai De-Eknamkul, Taksina Chuanasa

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Use Of Three Thai Indigenous Vegetables As Potential Dietary Fiber Sources For Health Food Product, Jeeravu Thongdon-A., Prapaipat Klungsupya, Thanchanok Muangman, Arkachai Tantrawong, Srisak Trangvacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Theodorakis Studies Effects Of Toxic Chemicals, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

When Substance Abuse And Mental Illness Combine, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

Solubility And Dissolution Enhancement Of Quercetin Via Preparation Of Spray Dried Microstructured Solid Dispersions, Ahmed Shawky Mohamed Ghanem, Hany Saleh, Sohair Mostafa El-Shanawany, El-Sayed Ali Ibrahim

The Thai Journal of Pharmaceutical Sciences

Quercetin (QC) is a bioflavonoid characterized with poor water solubility that limits its oral bioavailability and hence its therapeutic applications. เท an attempt to enhance its solubility and dissolution rate, both binary and ternary microstructur...

Bioequivalence Study Of 300 Mg Irbesartan Film-Coated Tablets Preparations In Healthy Thai Volunteers, Porranee Puranajoti, Peerawong Werarak, Burapat Intawong, Jarunee Hongrapipat, Rungrudee Talubsri, Soravee Sangsuriyawong, Temsiri Kuamsuk

The Thai Journal of Pharmaceutical Sciences

Irbesartan, an angiotensin II receptor antagonist, is indicated for the treatment of essential hypertension alone or in combination with other antihypertensive agents. The purpose of this study was to compare the bioavailability of two formulations of ir...

Quantitative Analysis Of Epigallocatechin Gallate In Young And Mature Assam Tea Leaf Extracts, Pattra Ahmadi Pirshahid, Thongchai Hemthanon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Pilot Study Of Antibacterial And Antiinflammatory Activities Of Indian Gooseberry (Phyllanthus Emblica L. Extract) Against Bacteria Associated With Pitted Keratolysis, Rattanasiri Giwanon., Krittiva Thisayakom, Pongsatom Limsiriwong, Saowaluck Ruengsri, Vichein Kheuynok, Kanchana Sriyam, Marudech Srisom, Darunee Pahusee, Sawai Nakakaew, Natthachest Ketmanee, Sontaya Peungsumrong, Chulerattana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Radical-Scavenging And Cellular Dna Protective Activities Of Active Fractions From Lansivm Domesticum Corr. Fruit, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cytotoxic Evaluation Of A Fruit Extract From Zanthoxylum Limonella In Human Dermal Fibroblast Cell Line Using Mtt Assay, Sarunva Laovitthayanggoon., Buppachart Potduang, Natthachest Ketmanee, Chuleratana Banchonglikitkul

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Fabrication Of Meloxicam Taste-Masked Oral Fast Disintegrating Tablet By Ion Exchange Resin And Cyclodextrin, Wipada Samprasit, Theerasak Rojanarata, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Praneet Opanasopit

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Development Of Garcinia Mangostana Extract In Liquid Crystal Cream For Topical Delivery System, Napa Bunma, Jirapan Moungjaroen, Prasan Tanguenyongwatana

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Formulation Of Ketoprofen Matrix Membrane For Transdermal Delivery Systems, Jirapomehai Suksaeree, Wiwat Pichayakorn, Chaowalit Monton, Apirak Sakunpak, Tun Chusut, Worawan Saingam, Fameera Madaka

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Cosmeceutical Development Of Oxyresveratrol From Mahad (Artocarpus Lakoocha Roxb.), Surapol Natakankitkul, Nicha Chareonmuang, Tawan Panyakhong, Worrapon Wangkananon

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Time Kill Study Of The In Vitro Activity Of Tigecycline Against Carbapenem-Resistant Klebsiella Pneumoniae, Maimun Halee, Wanchai Treyaprasert, Pompan Koomanachai, Duangdao Waywa

The Thai Journal of Pharmaceutical Sciences

No abstract provided.