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Articles 151 - 180 of 190
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Human Cytochrome P450, Pichayapa Seeka, Nuansri Niwattisaiwong, Warangkana Warisnoicharoen, Thidarat Winitthana, Mayuree H. Tantisira, Somsong Lawanprasert
Effects Of The Standardized Extract Of Centella Asiatica Eca233 On Human Cytochrome P450, Pichayapa Seeka, Nuansri Niwattisaiwong, Warangkana Warisnoicharoen, Thidarat Winitthana, Mayuree H. Tantisira, Somsong Lawanprasert
The Thai Journal of Pharmaceutical Sciences
The standardized extract of Centella asiatica ECa233 (ECa233) was shown to exhibit learning and memory enhancing effects. Beside toxicity testing data, safety data regarding drug interaction is also required. The purpose of this study was to investigate ...
Fabrication Of Lipospheres For Paclitaxel And Assessment Of In Vitro Cytotoxicity Against U373 Cancer Cell Lines, Nilakshi Nerkar, Amrita Bajaj, Shruti Shrikhande, Darshana Jain
Fabrication Of Lipospheres For Paclitaxel And Assessment Of In Vitro Cytotoxicity Against U373 Cancer Cell Lines, Nilakshi Nerkar, Amrita Bajaj, Shruti Shrikhande, Darshana Jain
The Thai Journal of Pharmaceutical Sciences
Paclitaxel is an antineoplastic drug, effective for various complex cancers especially ovarian and breast cancer. Due to its high hydrophobicity, an adjuvant such as polyethoxylated castor oil (Cremophor EL) has to be used in its clinical administration; however, it causes serious side-effects. Inclusion of paclitaxel in lipid matrix (lipospheres) has been proved to be a good approach to eliminate the need for Cremophor EL and to prolong the release of the drug. This paper describes the development of lipospheres as carriers for paclitaxel. Lipospheres constituted of bioacceptable and biodegradable lipids were fabricated and characterised. Scanning electron microscopy (SEM), differential scanning …
Inhibition Of Human Cytochrome P450 In Vitro By Phyllanthus Amarus And Phyllanthus Emblica Aqueous Extracts, Napaporn Anannarukan, Nuansri Niwattisaiwong, Warangkana Warisnoicharoen, Thidarat Winitthana, Pornpen Pramyothin, Chaiyo Chaichantipyuth, Somsong Lawanprasert
Inhibition Of Human Cytochrome P450 In Vitro By Phyllanthus Amarus And Phyllanthus Emblica Aqueous Extracts, Napaporn Anannarukan, Nuansri Niwattisaiwong, Warangkana Warisnoicharoen, Thidarat Winitthana, Pornpen Pramyothin, Chaiyo Chaichantipyuth, Somsong Lawanprasert
The Thai Journal of Pharmaceutical Sciences
Phyllanthus amarus Schum. & Thonn. and Phyllanthus emblica Linn, are well-known as medicinal herbs with many pharmacological effects. To develop these plants for medical purpose, herb-d'ug interaction study is needed to assure safety of using these plant...
The Prevalence Of Chronic Kidney Disease Among Gout Patients In Nongjik Hospital, Pattani Province, Nealnad Cheyoe, Metta Kuning, Apiradee Lim
The Prevalence Of Chronic Kidney Disease Among Gout Patients In Nongjik Hospital, Pattani Province, Nealnad Cheyoe, Metta Kuning, Apiradee Lim
The Thai Journal of Pharmaceutical Sciences
This study investigated the prevalence of chronic kidney disease (CKD) and identified factors: body mass index (BMI), hypertension (HT), diabetes mellitus (DM), dyslipidemia, diuretic use, anti-gout and serum uric acid associated with CKD among gout pati...
Anti-Anaemic Activity Of Some Plants In Cucurbitaceae On Phenylhydrazine-Induced Anaemic Rats, V.S. Saravanan, S. Manokaran
Anti-Anaemic Activity Of Some Plants In Cucurbitaceae On Phenylhydrazine-Induced Anaemic Rats, V.S. Saravanan, S. Manokaran
The Thai Journal of Pharmaceutical Sciences
The present study was focused to evaluate the anti-anaemic activity of Mukia maderaspatana (MM) and K ed rostis foe tid issim a (KF) of Cucurbitaceae family. Anaemia was induced by administration of phenylhydrazine in the dose of 10 mg/kg for 8 days. The...
Investigation Of Ghatti Gum As A Carrier To Develop Sustained Release Floating Tablets Of Diltiazem Hydrochloride, Valluru Ravi, T.M. Pramod, Siddaramaiah
Investigation Of Ghatti Gum As A Carrier To Develop Sustained Release Floating Tablets Of Diltiazem Hydrochloride, Valluru Ravi, T.M. Pramod, Siddaramaiah
The Thai Journal of Pharmaceutical Sciences
The aim of the present work was to prepare floating tablets of diltiazem hydrochloride using ghatti gum as a matrix polymer. The tablet formulations were prepared by varying the concentrations of ghatti gum, sodium bicarbonate and hydroxy propyl methyl c...
Author Index,Keyword Index, N/A
Author Index,Keyword Index, N/A
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Variation Of Total Curcuminoids And Volatile Oil Content In Turmeric Rhizome In Indonesia, Weravut Pothitirat, Sundari Desi, Phatsawee Jansook, Kingkan Sanpanya, Wandee Gritsanapan
Variation Of Total Curcuminoids And Volatile Oil Content In Turmeric Rhizome In Indonesia, Weravut Pothitirat, Sundari Desi, Phatsawee Jansook, Kingkan Sanpanya, Wandee Gritsanapan
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Determination Of Total Dietary Fiber Content And Antioxidant Capacity Of Some Thai Local Vegetables Using Photochemiluminescence Assay, Jeeravu Thongdon-A., Prapaipat Klungsupya, Srisak Trangvacharakul, Chuleeratana Banchonglikitkul
Determination Of Total Dietary Fiber Content And Antioxidant Capacity Of Some Thai Local Vegetables Using Photochemiluminescence Assay, Jeeravu Thongdon-A., Prapaipat Klungsupya, Srisak Trangvacharakul, Chuleeratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Comparative Study Of Anti-Oxidant Activity Of Leaf Extracts From Three Varieties Pomegranate, Pattra Ahmadi Pirshahid., Sarunya Laovitthayanggoon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul
Comparative Study Of Anti-Oxidant Activity Of Leaf Extracts From Three Varieties Pomegranate, Pattra Ahmadi Pirshahid., Sarunya Laovitthayanggoon, Yaowaluk Khamphan, Phatsuda Chueboonmee, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Effect Of Gamma-Irradiation On The Production Of Artemisinin In Artemisia Annua, Chawanop Kananukool, Thonghchai Koobkokkruad, Chalermpol Kirdmanee, Wanchai De-Eknamkul
Effect Of Gamma-Irradiation On The Production Of Artemisinin In Artemisia Annua, Chawanop Kananukool, Thonghchai Koobkokkruad, Chalermpol Kirdmanee, Wanchai De-Eknamkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Gallic Acid And Derivatives As Acetylcholinesterase Inhibitors, Suttinee Santa-Arthampreecha, Suwita Samakthanasan, Worawan Kitphati, Jaturong Pratuangdejkul, Veena Nukoolkam
Gallic Acid And Derivatives As Acetylcholinesterase Inhibitors, Suttinee Santa-Arthampreecha, Suwita Samakthanasan, Worawan Kitphati, Jaturong Pratuangdejkul, Veena Nukoolkam
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Evaluation On Anti-Oxidant, Anti-Mutagenic And Cytotoxic Properties Of Active Fractions Of Thai “Long-Kong” (Lansium Domesticum Corr.) Fruits, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul, Srichan Phomchirasilp
Evaluation On Anti-Oxidant, Anti-Mutagenic And Cytotoxic Properties Of Active Fractions Of Thai “Long-Kong” (Lansium Domesticum Corr.) Fruits, Prapaipat Klungsupya, Nava Suthepakul, Sarunya Laovitthayanggoon, Jeerayu Thongdon-A, Srisak Trangwacharakul, Srichan Phomchirasilp
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Anti-Oxidative Effects Against Tight Junction Barrier Disruption Of Proteins Isouated From Cajanus Cajan, Muangman T., Klungsupya P, Leelamanit W, Watari A, Yagi K
Anti-Oxidative Effects Against Tight Junction Barrier Disruption Of Proteins Isouated From Cajanus Cajan, Muangman T., Klungsupya P, Leelamanit W, Watari A, Yagi K
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Development Of Solid Lipid Nanoparticles Containing Astaxanthin From Shrimp Shell Extract, Kritsada Roopvai, Parkpoom Tengamnuay, Prapasri Sinswat
Development Of Solid Lipid Nanoparticles Containing Astaxanthin From Shrimp Shell Extract, Kritsada Roopvai, Parkpoom Tengamnuay, Prapasri Sinswat
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Fabrication And Evaluation Of Cationic Exchange Polystyrene Nanofibers For Oral Drug Delivery, Todsapon Nitanan, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Theerasak Rojanarata, Praneet Opanasopit
Fabrication And Evaluation Of Cationic Exchange Polystyrene Nanofibers For Oral Drug Delivery, Todsapon Nitanan, Prasert Akkaramongkolpom, Tanasait Ngawhirunpat, Theerasak Rojanarata, Praneet Opanasopit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Effects Of Dry Binders On The Mechanical And Disintegration Properties Of Nava-Kote Tablets, Chaivut Lorpongpaiboon, Thitianan Kulsirirat, Kanagam Hammaworachat, Siracha Kasemsuwan, Sunee Channarong
Effects Of Dry Binders On The Mechanical And Disintegration Properties Of Nava-Kote Tablets, Chaivut Lorpongpaiboon, Thitianan Kulsirirat, Kanagam Hammaworachat, Siracha Kasemsuwan, Sunee Channarong
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Development Of Dietary Supplement Tablets Containing The Extract Of Mangosteen Fruit Rind, Methanee Khoprasert, Pennapa Srichaiyon, Cholthicha Insom, Wiriyapom Sirikul, Werayut Pothitirat, Wandee Gritsanapan, Orawan Chitvanich
Development Of Dietary Supplement Tablets Containing The Extract Of Mangosteen Fruit Rind, Methanee Khoprasert, Pennapa Srichaiyon, Cholthicha Insom, Wiriyapom Sirikul, Werayut Pothitirat, Wandee Gritsanapan, Orawan Chitvanich
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Formulation Development Of Multilayer Sustained Release Tablets Of Sodium Valproate Combined With Valproic Acid, Worawan Saingam, Poj Kulvanich
Formulation Development Of Multilayer Sustained Release Tablets Of Sodium Valproate Combined With Valproic Acid, Worawan Saingam, Poj Kulvanich
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Quantitative Analysis Of “Tee Ka Tuk” Formulation Using Tlc-Densitometric Method, Maneekran Napakraw, Thitima Lhinhatrakool, Prasan Tanguenyongwatana
Quantitative Analysis Of “Tee Ka Tuk” Formulation Using Tlc-Densitometric Method, Maneekran Napakraw, Thitima Lhinhatrakool, Prasan Tanguenyongwatana
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Author Index, N/A
Floating And Mucoadhesive System Of Furosemide: Development And In Vitro Evaluation, Krunal Takarkhede, Dilesh Jagdish, Shagufta Khan, Pramod Yeole
Floating And Mucoadhesive System Of Furosemide: Development And In Vitro Evaluation, Krunal Takarkhede, Dilesh Jagdish, Shagufta Khan, Pramod Yeole
The Thai Journal of Pharmaceutical Sciences
Furosemide is poorly soluble in acidic pH and absorbed from the upper part of the Gl tract. We, therefore, aimed to develop a sustained release gastroretentive beads containing furosemide inclusion complex. The different formulations of floating beads we...
Influence Of Ephx1 Polymorphism And Clinical Factors On Carbamazepine Resistant Epilepsy, Khanistha Tuanthaisong, Yotin Chinvarun, Mayuree H. Tantisira, Pornpimol Kijsanayotin
Influence Of Ephx1 Polymorphism And Clinical Factors On Carbamazepine Resistant Epilepsy, Khanistha Tuanthaisong, Yotin Chinvarun, Mayuree H. Tantisira, Pornpimol Kijsanayotin
The Thai Journal of Pharmaceutical Sciences
The treatment outcomes of carbamazepine (CBZ) vary widely among patients. Single nucleotide polymorphisms (SNPs) in genes involved in pharmacokinetics and pharmacodynamics of CBZ may influence patients’ response to CBZ. We aimed to investigate the asso...
Simultaneous Spectrophotometric Determination Of Difloxacin And Enrofloxacin In Urine Samples By Partial Least Squares Regression (Pls) And Direct Orthogonal Signal Correction-Partial Least Squares Regression (Disc-Ols) Methods, Kuldeep Kaur, Ashok Kumar Malik, Baldev Singh, M. Godarzi
Simultaneous Spectrophotometric Determination Of Difloxacin And Enrofloxacin In Urine Samples By Partial Least Squares Regression (Pls) And Direct Orthogonal Signal Correction-Partial Least Squares Regression (Disc-Ols) Methods, Kuldeep Kaur, Ashok Kumar Malik, Baldev Singh, M. Godarzi
The Thai Journal of Pharmaceutical Sciences
Simultaneous determination of difloxacin and enrofloxacin using two chemometric methods, partial least squares regression (PLS) and direct orthogonal signal correction-partial least squares regression (DOSC-PLS) is described in this paper. The simultaneous determination of these drugs is difficult due to spectral interferences. The calibration graphs were linear in the range of 1-10 μg mL-1 and 1-9 μg mL-1 with detection limits of 0.52 and 0.15 μg mL-1 for difloxacin and enrofloxacin, respectively. The experimental calibration matrix was designed with 25 mixtures of these drugs. The PLS and DOSC-PLS were used for multivariate calibration of spectrophotometric data. The root mean square error …
Facile Derivative Uv Spectroscopy Method: Simultaneous Estimation Of Tinidazole And Fluconazole In Combined Tablet Dosage Form, Saurabh Pandey, Preeti Pandey, Shaifali Dubey, Udisha Chaturvedi, Awani K. Rai
Facile Derivative Uv Spectroscopy Method: Simultaneous Estimation Of Tinidazole And Fluconazole In Combined Tablet Dosage Form, Saurabh Pandey, Preeti Pandey, Shaifali Dubey, Udisha Chaturvedi, Awani K. Rai
The Thai Journal of Pharmaceutical Sciences
Two derivative spectrophotometric methods have been developed for simultaneous determination of tinidazole and fluconazole in pharmaceutical formulations. The first method depends on utilization of first derivative UV spectrophotometry, with zero-crossing and peak-to-base measurement at 260.57 & 264.23 nm for fluconazole and 263.86 & 318.85 nm for tinidazole. The second method, compensation technique depends on first derivative of the ratio-spectra by measurements of the amplitudes for tinidazole and fluconazole. Calibration graphs were established for tinidazole and fluconazole in the range of 10-100 μg ml-1 and 2-20 μg ml-1, respectively. All proposed methods have been extensively validated. The results were found to …
Simultaneous Estimation Of Cefixime And Cloxacillin In Human Plasma By Reversed Phase-Hplc With Uv Detection, Sommath D. Bhinge, Sharangouda M. Malipatil, Lalit V. Sonawane
Simultaneous Estimation Of Cefixime And Cloxacillin In Human Plasma By Reversed Phase-Hplc With Uv Detection, Sommath D. Bhinge, Sharangouda M. Malipatil, Lalit V. Sonawane
The Thai Journal of Pharmaceutical Sciences
An accurate, rapid and simple reversed-phase high performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous estimation of cefixime, cloxacillin and for chloramphenicol (internal standard) in human plasma. Chromatographic separation was accomplished using CAPCELL PAK C8 (4.6 mm Ó 250 mm, 5 μm) analytical column using phosphate buffer, methanol and acetonitrile (40:45:15) as eluent. Detection and quantification were performed by UV/Vis detection at 225 nm. The lower limit of detection and quantification were 0.01 μg†mL-1 and 0.25 μg†mL-1 for cefixime, 0.03 μg†mL-1 and 0.39 μg†mL-1 for cloxacillin. The calibration curves were linear over the concentration range 0.5 to …
Thrombolytic Activity Of Some Spices And Plants Available In Bangladesh, Md. Rakib Ai-Manun, Nabiha Amrin, Jahura Begum, Md. Abdul Mazid
Thrombolytic Activity Of Some Spices And Plants Available In Bangladesh, Md. Rakib Ai-Manun, Nabiha Amrin, Jahura Begum, Md. Abdul Mazid
The Thai Journal of Pharmaceutical Sciences
Thrombolytic activities of some plants, namely Tamarindus indica (Fabaceae), Flemingia congesta (Fabaceae), Lawsonia inermis (Lythraceae), Mesua nagassarium (Clusiaceae, and spices, namely Coriandrum sativum (Apiaceae), Curcuma longa (Zingiberaceae), Cinnamomum tamala (Lauraceae), Nigella sativa (Ranunculaceae), Eugenia aromaticum (Myrtaceae), available in Bangladesh, were evaluated using an in vitro model. The thrombolytic activity in terms of percentage of weight loss of in vitro formed clots were found as C. sativum 43.25 ± 7.18%, C. longa 53.32 ± 4.96%, C. tamala 22.10 ± 3.18%, N. sativa 28.49 ± 3.72%, E. aromaticum 32.18 ± 3.10%, T. indica 28.91 ± 2.29%, F. congesta 35.27 ± 7.35%, L. …
Lactobacillus Plantarum T23/3 As A Potential Probiotic Strain Isolated From Faces, Titpawan Nakpheng, Rosainee Kha, Neelam Balekar, Sanae Kaewnopparat, Teerapol Srichana
Lactobacillus Plantarum T23/3 As A Potential Probiotic Strain Isolated From Faces, Titpawan Nakpheng, Rosainee Kha, Neelam Balekar, Sanae Kaewnopparat, Teerapol Srichana
The Thai Journal of Pharmaceutical Sciences
The present study was undertaken to evaluate the properties of Lactobacillus plantarum T23/3 isolated from the feces of healthy elderly volunteer. The L. plantarum T23/3 showed better tolerance property to bile acid, simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), and exhibited antimicrobial activity against tested enteropathogens. It formed macroscopic granules with surface hydrophobicity and co-aggregated with tested microbial strain. It was resistant to some antibiotics used for treatment of diarrhea so there is possibility to co-administer L. plantarum as probiotic with antidiarrheal therapy. Furthermore, adhesion and significant potential for decreasing adhesion of pathogens (E. coli 2601 and V. …
Application Of A Stability-Indicating Hptlc Method For Simultaneous Determination Of Chloramphenicol And Dexamethasone Sodium Phosphate In Eye Drop, Yimer Seid, Araya Hymete, Adnan A. Bekhit
Application Of A Stability-Indicating Hptlc Method For Simultaneous Determination Of Chloramphenicol And Dexamethasone Sodium Phosphate In Eye Drop, Yimer Seid, Araya Hymete, Adnan A. Bekhit
The Thai Journal of Pharmaceutical Sciences
A high performance thin layer chromatography (HPTLC) method was developed and validated for the simultaneous quantification of dexamethasone sodium phosphate and chloramphenicol in eye drop. The HPTLC separation was achieved on an aluminum-backed layer of silica gel 60F254 using acetonitrile: water: ammonia (10:3:0.5 v/v/v), pH adjusted to 7.8 with 1M HCl, as a mobile phase. The densitometric determination of dexamethasone phosphate and chloramphenicol was carried out at 262 nm. Calibration curves for dexamethasone phosphate and chloramphenicol were linear in the range of 80-300 ng and 400-1400 ng, respectively. The method was validated according to International Conference on Harmonization (ICH) guidelines …
Enhancement Of Wttability And In Vitro Dissoution Properties Of Lercanidipine Hydrochloride By Solid Dispersion Technique, Suneel Pandey, Ekunkumar Chandekar, Amarnath Wattamwar, Sachin Pandit, Hemant Joshee, Arun Patil
Enhancement Of Wttability And In Vitro Dissoution Properties Of Lercanidipine Hydrochloride By Solid Dispersion Technique, Suneel Pandey, Ekunkumar Chandekar, Amarnath Wattamwar, Sachin Pandit, Hemant Joshee, Arun Patil
The Thai Journal of Pharmaceutical Sciences
The aim of the present study was to improve lercanidipine HCl solubility and in vitro dissolution rate by preparing solid dispersion with polyethylene glycol (PEG) 6000 using the solvent evaporation technique. Solid dispersions with PEG 6000 (as carriers) were prepared in drug: carrier (1:1, 1:5 and 1:10) ratios along with the corresponding physical mixtures. Analytical techniques, FT-IR spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to characterize the drug in the physical mixtures and solid dispersions. The solubility and wettability studies of solid dispersions as well as physical mixtures showed greater improvement compared to the pure drug. …