Pharmacology, Toxicology and Environmental Health Commons^™

Designing And Synthesizing A Warhead-Fragment Inhibitory Ligand For Ivyp1 Through Fragment-Based Drug Discovery, Samuel Moore

Symposium of Student Scholars

Fragment-based drug discovery (FBDD) is a powerful tool for developing anticancer and antimicrobial agents. Within this, magnetic resonance spectroscopy (NMR) provides a comprehensive qualitative and quantitative approach to screening and validating weak and robust binders with targeted proteins, making NMR among the most attractive strategies in FBDD. Inhibitor of vertebrate lysozyme (Ivyp1) of P. aeruginosa serves as an excellent target because of its active cellular location and implications in clinical prognosis for cystic fibrosis and immunocompromised patients. This study uses current NMR and biophysical techniques to develop a covalent, fragment-linked warhead inhibitor for Ivyp1 through synthetic methods, warhead linking, and …

Do Environmental Toxins Predict Violent Crimes?, Tyler Stahl

Symposium of Student Scholars

Do chemical pollutants that persistent in the environment and bioaccumulate in the body affect human health and behavior? Could these Persistent, Bioaccumulative, and Toxic (PBT) chemicals play a role in the cause of violent crimes due to deterioration of mental and cognitive functions? In the past, Mercury, a PBT chemical, has been shown in salmon to be associated with aggression. Could similar aggression occur in humans exposed to mercury through a toxic spill? Two sources of data are utilized in this analysis. The Environmental Protection Agency’s (EPA) Annual Toxic Release Inventory publishes data on toxic releases into the environment and …

Manipulation Of The Microbiome In The Gut Of The Fruit Fly To Alleviate Cadmium Bioaccumulation, Natasya Tamba

Symposium of Student Scholars

Cadmium (Cd) poisoning contributes to severe bodily detriments characterized by kidney failure, osteomalacia, and osteoporosis, otherwise known as Itai-Itai disease. The ingestion of cadmium contaminated foods primarily causes these conditions. There are no treatments to remove cadmium once absorbed, resulting in bioaccumulation. In this study, we are developing a method to manipulate the community of microorganisms (microbiome) living within the gastrointestinal (GI) tract of the fruit fly (Drosophila melanogaster), intending to use microorganisms to reduce the availability of ingested cadmium.

The biodiversity of microorganisms within the GI tract is responsible for metabolizing substances that the body cannot perform. …

How Does The Exploitation And Degradation Of Finite Natural Resources By Industrial Oil Producers Effect Our Future Planetary Environment?, Zachary J. King Mr.

Symposium of Student Scholars

Zachary King

Dr. Tu

26 March 2015

GEOG 3700

Abstract

The purpose of this presentation is to communicate content of the reports given by credible institution on the degradation and exploitation of finite natural resources by corporate institutions, for short term financial gain, and how it will effect the future planetary environment. Methods used in obtaining this research range from point source observation directly from oil spills in the Gulf or pipe leaks in the Mid-West, to analytical and numerical data quantifications gathered over a period of two decades. This presentation encompasses a wide scope of information concerning the way …