Open Access. Powered by Scholars. Published by Universities.®
Pharmacology, Toxicology and Environmental Health Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biology (2)
- Medicinal Chemistry and Pharmaceutics (2)
- Natural Products Chemistry and Pharmacognosy (2)
- Other Pharmacology, Toxicology and Environmental Health (2)
- Pharmacy and Pharmaceutical Sciences (2)
-
- Alternative and Complementary Medicine (1)
- Bioinformatics (1)
- Biotechnology (1)
- Cancer Biology (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Diseases (1)
- Food Chemistry (1)
- Food Science (1)
- Integrative Biology (1)
- Laboratory and Basic Science Research (1)
- Medicinal and Pharmaceutical Chemistry (1)
- Molecular, Genetic, and Biochemical Nutrition (1)
- Nutrition (1)
- Other Pharmacy and Pharmaceutical Sciences (1)
- Pharmaceutics and Drug Design (1)
- Pharmacology (1)
- Respiratory Tract Diseases (1)
- Toxicology (1)
- Translational Medical Research (1)
- Virus Diseases (1)
- Keyword
-
- MMP (2)
- ROS (2)
- ACE2 (1)
- Anti-tumor (1)
- Apoptosis (1)
-
- Ashwagandha (1)
- Biochanin A (1)
- COVID-19 (1)
- Caspase-3 (1)
- Cell cycle kinetics (1)
- Cell viability (1)
- Cervical cancer (1)
- DNA fragmentation (1)
- Expression analyses (1)
- Honeybee propolis (1)
- Molecular docking (1)
- Mpro (1)
- Nuclear fragmentation (1)
- Ovarian carcinoma (1)
- Pandemic (1)
- Piperine (1)
- Prevention (1)
- TMPRSS2 (1)
- Viral replication (1)
- Wound healing (1)
Articles 1 - 3 of 3
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad
Piperine Encourages Apoptosis In Human Cervical Adenocarcinoma Cells Through Ros Generation, Dna Fragmentation, Caspase-3 Activation And Cell Cycle Arrest, Asif Jafri, Juhi Rais, Sudhir Kumar, Md Arshad
Research Symposium
Background: Cancer is one of the most common destructive diseases and the second leading cause of death in humans. Among cancer, cervical cancer is the second most common malignancy among women globally. Thus, there is a continuous need to search for chemotherapeutic chemicals or naturally occurring drugs to resolve this global health problem. Piperine (1-piperoylpeperdine) is present in the fruits of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). It possesses several pharmacological properties and in the present study we have evaluated its anti-cancer potential on human cervical adenocarcinoma (HeLa) cells.
Methods: The anti-proliferative effect …
International Conference On Cancer Health Disparities, Juhi Rais, Asif Jafri, Neelam Shivnath, Habiba Khan, Md Arshad
International Conference On Cancer Health Disparities, Juhi Rais, Asif Jafri, Neelam Shivnath, Habiba Khan, Md Arshad
Research Symposium
Background: Biochanin A, an isoflavone that is mainly present in red clover, has potent chemopreventive properties against many cancers. Ovarian carcinoma is fifth most common and deadliest gynaecological malignancy that causes the highest mortality in females worldwide. Hence a substantial need for new therapies for combating this gynaecological malignancy arises.
Methods: The present study aimed to investigate anti-cancerous potentials of biochanin A on cultured human ovarian carcinoma PA-1 cells through the cell viability assay, cellular apoptosis, disruption of mitochondrial membrane potential (MMP), involvement of ROS, cell cycle kinetics, and expression of apoptosis-related genes namely, p53, Bax, Bcl-2, Noxa and Puma. …
Cell-Based Experimental Evidence To The Anti-Covid-19 Potential Of Ashwagandha And Honeybee Propolis Ingredients, Renu Wadhwa, Durai Sundar, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul
Cell-Based Experimental Evidence To The Anti-Covid-19 Potential Of Ashwagandha And Honeybee Propolis Ingredients, Renu Wadhwa, Durai Sundar, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul
Research Symposium
Background: The COVID-19 pandemic emerged in December 2019 by a novel strain of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has led to new endeavours in repurposing of existing drugs, anti-COVID-19 vaccine and drug development. Natural products, due to their general safety and wider availability, have attracted research and public attention. In this study, we report anti-COVID potential of compounds from honeybee propolis and Ayurvedic herb, Ashwagandha. Effect of active ingredients was studied on human cell surface receptors (ACE-2:Angiotensin Converting Enzyme-2/Spike protein and TMPRSS2:Transmembrane Protease Serine 2), critical for virus infection and virus main protease (Mpro, essential for virus replication), …