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Articles 31 - 38 of 38
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Antidepressant Stimulation Of Cdp-Diacylglycerol Synthesis Does Not Require Monoamine Reuptake Inhibition, Ashiwel S. Undieh, Marwa A. Aboukhatwa
Antidepressant Stimulation Of Cdp-Diacylglycerol Synthesis Does Not Require Monoamine Reuptake Inhibition, Ashiwel S. Undieh, Marwa A. Aboukhatwa
Publications and Research
Background: Recent studies demonstrate that diverse antidepressant agents increase the cellular production of the nucleolipid CDP-diacylglycerol and its synthetic derivative, phosphatidylinositol, in depression-relevant brain regions. Pharmacological blockade of downstream phosphatidylinositide signaling disrupted the behavioral antidepressant effects in rats. However, the nucleolipid responses were resistant to inhibition by serotonin receptor antagonists, even though antidepressant-facilitated inositol phosphate accumulation was blocked. Could the neurochemical effects be additional to the known effects of the drugs on monoamine transmitter transporters? To examine this question, we tested selected agents in serotonin-depleted brain tissues, in PC12 cells devoid of serotonin transporters, and on the enzymatic activity of …
Maternal Cocaine Administration In Mice Alters Dna Methylation And Gene Expression In Hippocampal Neurons Of Neonatal And Prepubertal Offspring, Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow, Ashiwel S. Undieh
Maternal Cocaine Administration In Mice Alters Dna Methylation And Gene Expression In Hippocampal Neurons Of Neonatal And Prepubertal Offspring, Svetlana I. Novikova, Fang He, Jie Bai, Nicholas J. Cutrufello, Michael S. Lidow, Ashiwel S. Undieh
Publications and Research
Previous studies documented significant behavioral changes in the offspring of cocaine-exposed mothers. We now explore the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring. Pregnant CD1 mice were administered either saline or 20 mg/kg cocaine twice daily on gestational days 8–19. Male pups from each of ten litters of the cocaine and control groups were analyzed at 3 (P3) or 30 (P30) days postnatum. Global DNA methylation, methylated DNA immunoprecipitation followed by CGI2 microarray profiling and bisulfite sequencing, as well as quantitative real-time RT-PCR gene expression …
Discovery Shook Medical, Pharmaceutical Industries, Aldemaro Romero Jr., David Gilmore
Discovery Shook Medical, Pharmaceutical Industries, Aldemaro Romero Jr., David Gilmore
Publications and Research
No abstract provided.
El Envenenamiento De Aves Por Plomo: Un Grave Problema Que Sí Tiene Solución, Aldemaro Romero Jr.
El Envenenamiento De Aves Por Plomo: Un Grave Problema Que Sí Tiene Solución, Aldemaro Romero Jr.
Publications and Research
No abstract provided.
Plomo: El Enemigo Invisible. La Contaminación Por Plomo En Venezuela, Aldemaro Romero Jr., Roberto Prato Ochoa
Plomo: El Enemigo Invisible. La Contaminación Por Plomo En Venezuela, Aldemaro Romero Jr., Roberto Prato Ochoa
Publications and Research
No abstract provided.
El Spray Nos Aniquilará, Aldemaro Romero Jr.
El Spray Nos Aniquilará, Aldemaro Romero Jr.
Publications and Research
No abstract provided.
Peces Y Delfines Mediterráneos, Con Altísimas Concentraciones De Mercurio, Aldemaro Romero Jr.
Peces Y Delfines Mediterráneos, Con Altísimas Concentraciones De Mercurio, Aldemaro Romero Jr.
Publications and Research
No abstract provided.
Estamos Contaminando El Agua Del Mar, Aldemaro Romero Jr.
Estamos Contaminando El Agua Del Mar, Aldemaro Romero Jr.
Publications and Research
No abstract provided.