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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Effects Of Red Diamondback Rattlesnake Venom On Keloid Dermal Fibroblasts In Vitro, Mackenzie Shelby Newman
Effects Of Red Diamondback Rattlesnake Venom On Keloid Dermal Fibroblasts In Vitro, Mackenzie Shelby Newman
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Keloid scarring is an inflammatory healing response to physical injury such as incision or piercing in the dermis. It is characterized by aberrant extracellular matrix production, the overaccumulation of mature collagen, and excessive fibroblast proliferation and migration beyond the borders of the original wound site. This results in swelling, depigmentation, itchiness, and pain akin to a benign tumor. Although there are myriad treatments for the condition, most are invasive and exhibit a high recurrence rate. Previous studies have shown that rattlesnake venom stimulates apoptosis in the skin via multiple specific mechanisms, largely composed of extracellular matrix and its receptors' interactions. …
"Characterization Of Red Diamondback Rattlesnake Venom Proteins On Cell Death And Function", Venus Ebrahimian
"Characterization Of Red Diamondback Rattlesnake Venom Proteins On Cell Death And Function", Venus Ebrahimian
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Snake venom is composed of many different toxins and protein components such as metalloproteases and phospholipase A2. Together, these proteins cause an up regulation in cell death pathways and disrupt the overall homeostasis of a living cell. The Red Diamondback Rattlesnake is abundantly available and well-known specie and has been used as a source for development of new drugs. It has been mainly used for the purposes of making anti-venom but it has also been therapeutically used for surgical purposes to act as an anti-aggregate. Integrins derived from RDB venom has been used for cancer cell treatment as well. Specifically …
Analysis Of Archived Dried Blood Spots By Mass Spectrometry For Vitamin D And Real-Time Pcr For Its Enzymes And Receptor, Amod N. Joshi
Analysis Of Archived Dried Blood Spots By Mass Spectrometry For Vitamin D And Real-Time Pcr For Its Enzymes And Receptor, Amod N. Joshi
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Vitamin D is an essential micronutrient required for maintenance of the skeletal system and its deficiency leads to diminished availability of calcium for maintaining bone mineralization. Vitamin D deficiency (VDD) during pregnancy and/or in early infancy can lead to rickets and a fragile bone state resulting in fractures with minimal forces. Such multiple unexplained fractures (MUF) present in infants at less than 6 months of age are often misdiagnosed as cases of child abuse. Therefore, it is important to evaluate the status of vitamin D in early infancy. The analysis of dried blood spots (DBS) provides a unique screening method …