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Articles 121 - 135 of 135
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Copper(Ii) Complexes Of Coumarin-Derived Schiff Bases And Their Anti-Candida Activity, Bernadette S. Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy Mccann, Andy Noble, Maureen Walsh
Copper(Ii) Complexes Of Coumarin-Derived Schiff Bases And Their Anti-Candida Activity, Bernadette S. Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy Mccann, Andy Noble, Maureen Walsh
Articles
The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper( II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity.
The Very Basics Of Sustainability - An Alternative Viewpoint (Slides With Audio) (Large File! To Speed Up Download, Right-Click On "Download" Link To Save To Own Pc.), Jim Mcgovern
Other resources
This presentation sets out the very basics of ‘sustainability’, although a definition of sustainability is not attempted. Some of the very basics are the context in which the Earth and humankind exist in space and time, the Earth’s climate, the Earth’s population and humankind’s options and choices. The author advocates keeping an open mind on all available options, including the use of oil, gas, coal, tar sands, carbon capture and sequestration, nuclear power etc., as well as the technologies that are more widely considered ‘green’. The author also argues that, in addressing the challenges that humankind faces, globally concerted effort …
Preparation, Characterization And Ecotoxicological Evaluation Of Four Environmentally Relevant Species Of N-Isopropylacrylamide And N-Isopropylacrylamide-Co-N-Tert-Butylacrylamide Copolymer Nanoparticles, Pratap Naha, Alan Casey, Tiziana Tenuta, Iseult Lynch, Kenneth Dawson, Hugh Byrne, Maria Davoren
Preparation, Characterization And Ecotoxicological Evaluation Of Four Environmentally Relevant Species Of N-Isopropylacrylamide And N-Isopropylacrylamide-Co-N-Tert-Butylacrylamide Copolymer Nanoparticles, Pratap Naha, Alan Casey, Tiziana Tenuta, Iseult Lynch, Kenneth Dawson, Hugh Byrne, Maria Davoren
Articles
Poly N-isopropylacrylamide and N-isopropylacrylamide / N-tert-butylacrylamide copolymer nanoparticles of 50 to 70 nm were prepared by free radical polymerisation. The particle sizes of the copolymer nanoparticles were measured in the test media Milli-Q water, Algae Media, Daphnia Media and Microtox Diluent as a function of temperature. Whereas in Milli-Q water the particle size was seen to decrease above the lower critical solution temperature of the thermoresponsive polymer, in the test media it was seen to increase significantly, indicative of aggregation. At the temperatures employed for the ecotoxicological studies all particles, with the exception of the 50:50 copolymer existed as nanoparticles, …
An Integrated Approach To The Toxicity Assessment Of Irish Marine Sediments Application Of Porewater Toxicity Identification Evaluation (Tie) To Irish Marine Sediments, Ailbhe Macken, Michelle Giltrap, Barry Foley, Evin Mcgovern, Brendan Mchugh, Maria Davoren
An Integrated Approach To The Toxicity Assessment Of Irish Marine Sediments Application Of Porewater Toxicity Identification Evaluation (Tie) To Irish Marine Sediments, Ailbhe Macken, Michelle Giltrap, Barry Foley, Evin Mcgovern, Brendan Mchugh, Maria Davoren
Articles
An integrated approach to the ecotoxicological assessment of Irish marine sediments was carried out between 2004 and 2007. Phase I Toxicity Identification Evaluation (TIE) of sediment porewaters from two sites on the east coast of Ireland were conducted. Initial Tier I screening of three Irish sites identified the need for TIE after significant toxicity was observed with Tisbe battagliai and the Microtox® assay at two of the assayed sites (Alexandra Basin and Dunmore East). Porewaters classified as toxic were characterised using four manipulations, ethylenediaminetetraacetic acid (EDTA) chelation, sodium thiosulphate addition, C18 Solid Phase Extraction (SPE) and Cation Exchange (CE) SPE. …
Reflection Contributions To The Dispersion Artefact In Ftir Spectra Of Single Biological Cells., Paul Bassan, Hugh Byrne, Joe Lee, Franck Bonnier, Colin Clarke, Paul Dumas, Ehsan Gazi, Michael Brown, Noel Clarke, Peter Gardner
Reflection Contributions To The Dispersion Artefact In Ftir Spectra Of Single Biological Cells., Paul Bassan, Hugh Byrne, Joe Lee, Franck Bonnier, Colin Clarke, Paul Dumas, Ehsan Gazi, Michael Brown, Noel Clarke, Peter Gardner
Articles
Fourier transform infrared spectra of a single cell in transflection geometry are seen to vary significantly with position on the cell, showing a distorted derivative-like lineshape in the region of the optically dense nucleus. A similar behaviour is observable in a model system of the protein albumin doped in a potassium bromide disk. It is demonstrated that the spectrum at any point is a weighted sum of the sample reflection and transmission and that the dominance of the reflection spectrum in optically dense regions can account for some of the spectral distortions previously attributed to dispersion artefacts. Rather than being …
Dispersion Medium Modulates Oxidative Stress Response Of Human Lung Epithelial Cells Upon Exposure To Carbon Nanomaterial Samples, Eva Herzog, Hugh Byrne, Maria Davoren, Alan Casey, Albert Duschl, Gertie Janneke Oostingh
Dispersion Medium Modulates Oxidative Stress Response Of Human Lung Epithelial Cells Upon Exposure To Carbon Nanomaterial Samples, Eva Herzog, Hugh Byrne, Maria Davoren, Alan Casey, Albert Duschl, Gertie Janneke Oostingh
Articles
Due to their large specific surface area, the potential of nanoparticles to be highly reactive and to induce oxidative stress is particularly high. In addition, some types of nanoparticles contain transition metals as trace impurities which are known to generate reactive oxygen species (ROS) in biological systems. This study investigates the potential of two types of single-walled carbon nanotube samples, nanoparticulate carbon black and crocidolite asbestos to induce ROS in lung epithelial cells in vitro. Carbon nanotube and carbon black samples were used as produced, without further purification or processing, in order to best mimic occupational exposure by inhalation of …
Raman Spectroscopy: A Potential Platform For The Rapid Measurement Of Carbon Nanotube-Induced Cytotoxicity, Peter Knief, Colin Clarke, Eva Herzog, Maria Davoren, Fiona Lyng, Aidan Meade, Hugh Byrne
Raman Spectroscopy: A Potential Platform For The Rapid Measurement Of Carbon Nanotube-Induced Cytotoxicity, Peter Knief, Colin Clarke, Eva Herzog, Maria Davoren, Fiona Lyng, Aidan Meade, Hugh Byrne
Articles
In this study the suitability of Raman spectroscopy for the determination of carbon nanotube mediated toxicity on human alveolar carcinoma epithelial cells (A549) is explored. The exposure of this cell line represents the primary pathway of exposure in humans, that of inhalation. Peak ratio analysis demonstrates a dose dependent response which correlates to previous toxicological studies. Principal component analysis is employed to further classify cellular response as a function of dose and to examine differences between spectra as a function of exposed concentration. To further illustrate the potential of Raman spectroscopy in this field, Partial Least Squares (PLS) regression and …
First Approaches To Standard Protocols And Reference Materials For The Assessment Of Potential Hazards Associated With Nanomaterialss, Gordon Chambers, Hugh Byrne, Iseult Lynch, Micheal Riediker, Hans Bouwmeester, Hans Marvin, Alan Casey, Markus Berges, Martin Clift, Teresa Fernandez, Lise Fjellsbo, Lucienne Juillerat, Gert Roebben, Christoph, Klein, Qinglan Wu, Vince Hackley, Jean-Pierre Kaiser, Wolfganag Kreyling, Michael Garner, Peter Hatto,, Kenneth Dawson
First Approaches To Standard Protocols And Reference Materials For The Assessment Of Potential Hazards Associated With Nanomaterialss, Gordon Chambers, Hugh Byrne, Iseult Lynch, Micheal Riediker, Hans Bouwmeester, Hans Marvin, Alan Casey, Markus Berges, Martin Clift, Teresa Fernandez, Lise Fjellsbo, Lucienne Juillerat, Gert Roebben, Christoph, Klein, Qinglan Wu, Vince Hackley, Jean-Pierre Kaiser, Wolfganag Kreyling, Michael Garner, Peter Hatto,, Kenneth Dawson
Articles
All new technologies have an inherent risk, which is typically assessed alongside the development of applications of the technology. This is also the case for nanotechnology: a key concern in the case of engineered nanomaterials (ENMs) is that due to their very small size, NMs can reach areas such as the cell that are inaccessible to other materials, such as implants and drugs. As a result of their large surface area, NMs may be more reactive than other larger materials. The large physical and chemical variability of NMs, and the fact that small changes can have large consequences, mean that …
When Every Drop Counts: The Public Health Impact Of Drought, Steven Konkel
When Every Drop Counts: The Public Health Impact Of Drought, Steven Konkel
Environmental Health Planning and Policy
No abstract provided.
A Model Compound Study: The Ecotoxicological Evaluation Of Five Organic Contaminants With A Battery Of Marine Bioassays, Ailbhe Macken, Michelle Giltrap, Barry Foley, Evin Mcgovern, Brendan Mchugh, Maria Davoren
A Model Compound Study: The Ecotoxicological Evaluation Of Five Organic Contaminants With A Battery Of Marine Bioassays, Ailbhe Macken, Michelle Giltrap, Barry Foley, Evin Mcgovern, Brendan Mchugh, Maria Davoren
Articles
This paper describes the ecotoxicological evaluation of five organic contaminants frequently detected in marine sediments (tributyltin, triphenyltin, benzo[a]pyrene, fluoranthene, and PCB 153) using three marine species (Vibrio fischeri, Tetraselmis suecica, and Tisbe battagliai). The sensitivity of each species varied for all compounds. The triorganotins were consistently the most toxic to all species. The applicability of each test system to assess the acute toxicity of environmental contaminants and their use in Toxicity Identification Evaluation (TIE) is discussed. Suitability of the Microtox and T. battagliai tests for employment in TIE studies were further assessed through spiking experiments with tributyltin. Results demonstrated that …
Ecotoxicological Investigations Of Pharmaceutical Compounds On A Battery Of Freshwater Test Species., Elaine Minagh
Ecotoxicological Investigations Of Pharmaceutical Compounds On A Battery Of Freshwater Test Species., Elaine Minagh
Masters
Currently interest in pharmaceuticals as potential environmental contaminants has increases significantly. This is due to the awareness of the possible adverse effects to human health and the environment caused by such contaminants. Within the past few years, the highly prescribed antidepressants, selective serotonin reuptake inhibitors (SSRI), have received attention as their occurrence in the environment has been recently documented. Prior to this, there was very little known about the ecotoxicity of SSRIs, and in particular sertraline hydrochloride. Similarly the cholesterol-lowering drugs, known as statins are among the most frequently prescribed agents in Ireland and worldwide for the treatment of coronary …
Combination Of Natural Variability Estimation With Real Time Measurement For Mushroom Shelf Life Assessment., Leixuri Aguirre
Combination Of Natural Variability Estimation With Real Time Measurement For Mushroom Shelf Life Assessment., Leixuri Aguirre
Doctoral
The shelf life of mushrooms (Agaricus bisporus) is affected by the natural variability of the produce which influences the perishable vegetable quality. One of the main causes of this variability is non-homogeneity in the product maturity at harvest, resulting in each vegetable batch being at a different stage of senescence. The present work aims to study a new approach to improve the assessment of the shelf life of mushrooms (Agaricus bisporus) taking into account this variability. The study of variability involved the: i) study of the shelf life, quality parameters and variability of the mushrooms and modelling these experimental laboratory …
The Involvement Of Calcium And Map Kinase Signaling Pathways In The Production Of Radiation-Induced Bystander Effects, Fiona Lyng, Paula Maguire, B. Mcclean, C. Seymour, Carmel Mothersill
The Involvement Of Calcium And Map Kinase Signaling Pathways In The Production Of Radiation-Induced Bystander Effects, Fiona Lyng, Paula Maguire, B. Mcclean, C. Seymour, Carmel Mothersill
Articles
Much evidence now exists regarding radiation-induced bystander effects, but the mechanisms involved in the transduction of the signal are still unclear. The mitogen-activated protein kinase (MAPK) pathways have been linked to growth factor-mediated regulation of cellular events such as proliferation, senescence, differentiation and apoptosis. Activation of multiple MAPK pathways such as the ERK, JNK and p38 pathways have been shown to occur after exposure of cells to radiation and a variety of other toxic stresses. Previous studies have shown oxidative stress and calcium signaling to be important in radiation-induced bystander effects. The aim of the present study was to investigate …
The Role Of Peroxidases In The Development Of Plants And Their Responses To Abiotic Stresses., Deborah Vicuna
The Role Of Peroxidases In The Development Of Plants And Their Responses To Abiotic Stresses., Deborah Vicuna
Doctoral
Peroxidases and its effects on plants were analysed. Peroxidases are involved in many physiological processes in plants, involving responses to biotic and abiotic stresses and the biosynthesis of lignin. Liglin is a polymer responsible for rendering the plant stronger and more rigid and also making the cell walls hydrophobic. Peroxidases are involved in the polymerization of the precursors of lignin. They are also involved in the scavenging of Reactive Oxygen Species (ROS), which are partially reduced forms of atmospheric oxygen, highly reactive, and capable of causing oxidative damage to the cell. Peroxidases can be a source of hydrogen peroxide (H2O2) …
Safety Performance On 20 Construction Sites In Dublin, Paul Mcevoy
Safety Performance On 20 Construction Sites In Dublin, Paul Mcevoy
Masters
Abstract The aim of this research was to assess factors affecting safety performance on twenty apartment construction sites in Dublin using qualitative and quantitative risk assessment techniques. The quantitative techniques involved observing compliance with recommended safety procedures. The qualitative techniques involved an assessment of site safety management documentation and semi structured interviews with site management regarding site safety procedures. The field work was carried out between November 2003 and October 2004. The results showed that five sites out of twenty had high standards of safety and prevented all possible falls from heights. The five best performing sites were characterised by …