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Articles 31 - 60 of 65
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Lenvatinib, Inderbir S. Padda, Mayur S. Parmar
Covid (Sars-Cov-2) Vaccine, Inderbir S. Padda, Mayur S. Parmar
Covid (Sars-Cov-2) Vaccine, Inderbir S. Padda, Mayur S. Parmar
HPD Articles
No abstract provided.
Aducanumab, Inderbir S. Padda, Mayur S. Parmar
Obeticholic Acid, Kristina Krupa, Vera Hapshy, Hiep Nguyen, Mayur S. Parmar
Obeticholic Acid, Kristina Krupa, Vera Hapshy, Hiep Nguyen, Mayur S. Parmar
HPD Articles
No abstract provided.
Understanding The Toxicity Of Single Hydrocarbons, Oil, And Dispersed Oil: A Species Sensitivity Assessment For Five Atlantic Coral Species, Nicholas R. Turner
Understanding The Toxicity Of Single Hydrocarbons, Oil, And Dispersed Oil: A Species Sensitivity Assessment For Five Atlantic Coral Species, Nicholas R. Turner
HCNSO Student Theses and Dissertations
Coral reefs are keystone coastal ecosystems that are at risk of exposure to petroleum hydrocarbons from a range of sources, including oil spill incidents and chronic runoff, and are usually one of the highest valued natural resources for protection in Net Environmental Benefit Analysis (NEBA)/Spill Impact Mitigation Assessment (SIMA) of response methods and environmental damage. Previous research evaluating hydrocarbon impacts to corals has resulted in no clear characterization of sensitivity, as work has generally focused on higher-level effects, compounded by significant variability in experimental methodology. This represents an important knowledge gap in oil spill preparedness and response as it relates …
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
HPD Articles
No abstract provided.
Iron Dextran, Sebastiano Failla, Mayur S. Parmar
Calcium Carbonate, Kristina Fritz, Katherine Taylor, Mayur S. Parmar
Calcium Carbonate, Kristina Fritz, Katherine Taylor, Mayur S. Parmar
HPD Articles
No abstract provided.
Famciclovir, Jennifer R. Semaan, Mayur S. Parmar
Doxycycline Hyclate, Reema S. Patel, Mayur S. Parmar
Doxycycline Hyclate, Reema S. Patel, Mayur S. Parmar
HPD Articles
No abstract provided.
Pramipexole, Raman Singh, Mayur S. Parmar
Teriparatide, Hacen Vall, Mayur S. Parmar
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
HPD Articles
No abstract provided.
Reserpine, Michelle Cheung, Mayur S. Parmar
Fosinopril, Kaitlyn Alessi, Mayur S. Parmar
Fluorescein, Amy-Grace Pothen, Mayur S. Parmar
Dornase Alfa, Rida Altaf, Mayur S. Parmar
Flucytosine, Inderbir S. Padda, Mayur S. Parmar
Lisinopril, Edgardo Olvera Lopez, Mayur S. Parmar, Venkata Satish Pendela, Jamie M. Terrell
Lisinopril, Edgardo Olvera Lopez, Mayur S. Parmar, Venkata Satish Pendela, Jamie M. Terrell
HPD Articles
No abstract provided.
Indinavir, Eliyah B. Pollak, Mayur S. Parmar
Lamivudine, Katherine Taylor, Kristina Fritz, Mayur S. Parmar
Lamivudine, Katherine Taylor, Kristina Fritz, Mayur S. Parmar
HPD Articles
No abstract provided.
Sodium Oxybate, Alvio Dominguez, Lucia Soca Gallego, Mayur S. Parmar
Sodium Oxybate, Alvio Dominguez, Lucia Soca Gallego, Mayur S. Parmar
HPD Articles
No abstract provided.
Pralidoxime, Rishab Gupta, Mayur S. Parmar
Tolterodine, Shreya Narain, Mayur S. Parmar
An Investigation Into The Relationships Between Bullying, Discrimination, Burnout And Patient Safety In Nurses And Midwives: Is Burnout A Mediator?, Judith Johnson, Lorraine Cameron, Lucy Mitchinson, Mayur Parmar, Gail Opio-Te, Gemma Louch, Angela Grange
An Investigation Into The Relationships Between Bullying, Discrimination, Burnout And Patient Safety In Nurses And Midwives: Is Burnout A Mediator?, Judith Johnson, Lorraine Cameron, Lucy Mitchinson, Mayur Parmar, Gail Opio-Te, Gemma Louch, Angela Grange
HPD Articles
BACKGROUND: Bullying and discrimination may be indirectly associated with patient safety via their contribution to burnout, but research has yet to establish this. AIMS: The aims of this study were to investigate the relationships between workplace bullying, perceived discrimination, levels of burnout and patient safety perceptions in nurses and midwives and to assess whether bullying and discrimination were more frequently experienced by Black, Asian and minority ethnic than White nurses and midwives. METHODS: In total, 528 nurses and midwives were recruited from four hospitals in the United Kingdom to complete a cross-sectional survey between February and March 2017. The survey …
Resveratrol And Pinostilbene Confer Neuroprotection Against Aging-Related Deficits Through An Erk1/2-Dependent Mechanism, Erika N. Allen, Sneha Potdar, Victor Tapias, Mayur Parmar, Cassia S. Mizuno, Agnes Rimando, Jane E. Cavanaugh
Resveratrol And Pinostilbene Confer Neuroprotection Against Aging-Related Deficits Through An Erk1/2-Dependent Mechanism, Erika N. Allen, Sneha Potdar, Victor Tapias, Mayur Parmar, Cassia S. Mizuno, Agnes Rimando, Jane E. Cavanaugh
HPD Articles
Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and …
Autoethnography As An Instrument For Professional (Trans) Formation In Pharmaceutical Care Practice, Daniela Álvares Machado Silva, Simone Araújo Medina Mendonça, Maureen O´Dougherty, Djenane Ramalho De Oliveira, Clarice Chemello
Autoethnography As An Instrument For Professional (Trans) Formation In Pharmaceutical Care Practice, Daniela Álvares Machado Silva, Simone Araújo Medina Mendonça, Maureen O´Dougherty, Djenane Ramalho De Oliveira, Clarice Chemello
The Qualitative Report
The recent inclusion of pharmacists in primary healthcare in Brazil through the Family Health Support Team has encouraged them to reflect on the need to change from a professional focused on medications to one focused on individuals. This autoethnography allowed a pharmacist to confront her perspectives on clinical practice between 2014 and 2016, a period when she decided to challenge her traditional training as a pharmacist centered on medications. Using pharmaceutical care practice as the theoretical framework that prompted the profession of pharmacy to change its focus to the patient, the authors collaborated to construct a monologue that engages readers …
The Er Retention Protein Rer1 Promotes Alpha-Synuclein Degradation Via The Proteasome, Hyo-Jin Park, Daniel Ryu, Mayur Parmar, Benoit I. Giasson, Nikolaus R. Mcfarland
The Er Retention Protein Rer1 Promotes Alpha-Synuclein Degradation Via The Proteasome, Hyo-Jin Park, Daniel Ryu, Mayur Parmar, Benoit I. Giasson, Nikolaus R. Mcfarland
HPD Articles
Abnormal accumulation of α-synuclein (αSyn) has been linked to endoplasmic-reticulum (ER) stress, defective intracellular protein/vesicle trafficking, and cytotoxicity. Targeting factors involved in ER-related protein processing and trafficking may, therefore, be a key to modulating αSyn levels and associated toxicity. Recently retention in endoplasmic reticulum 1 (RER1) has been identified as an important ER retrieval/retention factor for Alzheimer's disease proteins and negatively regulates amyloid-β peptide levels. Here, we hypothesized that RER1 might also play an important role in retention/retrieval of αSyn and mediate levels. We expressed RER1 and a C-terminal mutant RER1Δ25, which lacks the ER retention/retrieval function, in HEK293 and …
Vectored Intracerebral Immunization With The Anti-Tau Monoclonal Antibody Phf1 Markedly Reduces Tau Pathology In Mutant Tau Transgenic Mice, Wencheng Liu, Lingzhi Zhao, Brittany Blackman, Mayur Parmar, Man Ying Wong, Thomas Woo, Fangmin Yu, Maria J. Chiuchiolo, Dolan Sondhi, Stephen M. Kaminsky, Ronald G. Crystal, Steven M. Paul
Vectored Intracerebral Immunization With The Anti-Tau Monoclonal Antibody Phf1 Markedly Reduces Tau Pathology In Mutant Tau Transgenic Mice, Wencheng Liu, Lingzhi Zhao, Brittany Blackman, Mayur Parmar, Man Ying Wong, Thomas Woo, Fangmin Yu, Maria J. Chiuchiolo, Dolan Sondhi, Stephen M. Kaminsky, Ronald G. Crystal, Steven M. Paul
HPD Articles
UNLABELLED: Passive immunization with anti-tau monoclonal antibodies has been shown by several laboratories to reduce age-dependent tau pathology and neurodegeneration in mutant tau transgenic mice. These studies have used repeated high weekly doses of various tau antibodies administered systemically for several months and have reported reduced tau pathology of ∼40-50% in various brain regions. Here we show that direct intrahippocampal administration of the adeno-associated virus (AAV)-vectored anti-phospho-tau antibody PHF1 to P301S tau transgenic mice results in high and durable antibody expression, primarily in neurons. Hippocampal antibody levels achieved after AAV delivery were ∼50-fold more than those reported following repeated systemic …
Quantifying The Toxicity Of 1-Methylnaphthalene To The Shallow-Water Coral, Porites Divaricata, For Use In The Target Lipid Model, Nicholas Turner
Quantifying The Toxicity Of 1-Methylnaphthalene To The Shallow-Water Coral, Porites Divaricata, For Use In The Target Lipid Model, Nicholas Turner
HCNSO Student Theses and Dissertations
The proximity of coral reefs to coastal urban areas and shipping lanes predisposes corals to petroleum pollution from multiple sources. Previous research has evaluated petroleum toxicity to coral using a variety of methodologies, including monitoring effects of acute and chronic spills, in situ exposures, and ex situ exposures with both adult and larval stage corals. Variability in toxicant, bioassay conditions, species and other methodological disparities among studies prevents comprehensive conclusions regarding the toxicity of hydrocarbons to corals. This research evaluated the 48-hour toxicity of 1-methylnaphthalene to Porites divaricata using a continuous-flow passive dosing system. The range-finding exposure evaluated the dosing …