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Pharmacology, Toxicology and Environmental Health Commons™

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Chulalongkorn University

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Articles 571 - 600 of 1538

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Floating Matrix Tablets Of Domperidone: Formulation And Optimization Using Simplex Lattice Design, Shailesh T. Prajapati, Laxmanbhai D., Chhaganbhai N. Patel Jan 2009

Floating Matrix Tablets Of Domperidone: Formulation And Optimization Using Simplex Lattice Design, Shailesh T. Prajapati, Laxmanbhai D., Chhaganbhai N. Patel

The Thai Journal of Pharmaceutical Sciences

One method of achieving sustained drug release is by the use of hydrophilic polymeric excipients directly compressed with active ingredients into tablets. Hydrophilic polymers swell in the presence of water to form hydrogel structures from which drugs ar...


Screening Of Antifungal Activities Of Barks Of Cinnamomum Species, M. Maridass Jan 2009

Screening Of Antifungal Activities Of Barks Of Cinnamomum Species, M. Maridass

The Thai Journal of Pharmaceutical Sciences

Antifungal activity of the essential oil from Cinnamomum species have been evaluated in this present study. Essential oils were collected through hydro distillation for 4 h from barks of C. sulphuratum, C. walaiwarense, C. travancoricum and C. malabatrum...


Effects Of Longan Seed Extract On Scopolamine-Induced Learning And Memory Deficit In Mice, Nattanan Losuwannarak, Cholatit Pasadhika, Mayuree H. Tantisira, Boonyong Tantisira Jan 2009

Effects Of Longan Seed Extract On Scopolamine-Induced Learning And Memory Deficit In Mice, Nattanan Losuwannarak, Cholatit Pasadhika, Mayuree H. Tantisira, Boonyong Tantisira

The Thai Journal of Pharmaceutical Sciences

Longan (Euphoria longana) seed is a traditional Chinese medicinal plant which has been claimed to have positive effect on deficit in learning and memory. In this study, the effects of crude ethanolic extracts of longan seed on learning and memory impairm...


Simultaneous Spectrophotometric Determination Of Carbidopa And Levodopa By Partial Least Squares Regression, Principal Component Regression And Least Squares Support Vector Machine Methods, Kuldeep Kaur, Ashok Kumar, Baldev Singh, M. Godarzi Jan 2009

Simultaneous Spectrophotometric Determination Of Carbidopa And Levodopa By Partial Least Squares Regression, Principal Component Regression And Least Squares Support Vector Machine Methods, Kuldeep Kaur, Ashok Kumar, Baldev Singh, M. Godarzi

The Thai Journal of Pharmaceutical Sciences

Three chemometric methods; partial least squares regression (PLS), principal component regression (PCR) and least-squares support vector machines (LS-SVM) were applied for simultaneous determination of carbidopa and levodopa in synthetic mixtures and rea...


Author Index, Keyword Index, N/A Jan 2009

Author Index, Keyword Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Flavonoid Glycosides From The Leaves Of Uvaria Rufa With Advanced Glycation End-Products Inhibitory Activity, Khanittha Deepralard, Kazuko Kawanishi, Masataka Moriyasu, Thitima Pengsuparp, Rutt Suttisri Jan 2009

Flavonoid Glycosides From The Leaves Of Uvaria Rufa With Advanced Glycation End-Products Inhibitory Activity, Khanittha Deepralard, Kazuko Kawanishi, Masataka Moriyasu, Thitima Pengsuparp, Rutt Suttisri

The Thai Journal of Pharmaceutical Sciences

Prolonged hyperglycemia in diabetic patients leads to the formation of advanced glycation end-products (AGEs) in their body tissues, which contribute to the development and progression of diabetic complications and aging. Preliminary screening of the eth...


Bioequivaience Study Of Two Different Formulations Of 300 Mg Gabapentin Capsule In Thai Healthy Volunteers, Supeecha Wittayalertpanya, Sumana Chompootaweep, Nongnuch Thaworn, Wondee Khemsri, Nantana Intanil Jan 2008

Bioequivaience Study Of Two Different Formulations Of 300 Mg Gabapentin Capsule In Thai Healthy Volunteers, Supeecha Wittayalertpanya, Sumana Chompootaweep, Nongnuch Thaworn, Wondee Khemsri, Nantana Intanil

The Thai Journal of Pharmaceutical Sciences

The objective of this study was to compare the bioavailability of new generic product of gabapentin with the innovator’s product. The study was performed in 20 Thai male healthy volunteers who received a single oral dose of 300 mg gabapentin capsule. D...


The Role Of National Science Journals: Information, Advocacy And Education, Alexander T. Florence Jan 2008

The Role Of National Science Journals: Information, Advocacy And Education, Alexander T. Florence

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


High-Performance Liquid Chromatographic Determination Of Asiatic Acid In Human Plasma, Phensri Thongnopnua Jan 2008

High-Performance Liquid Chromatographic Determination Of Asiatic Acid In Human Plasma, Phensri Thongnopnua

The Thai Journal of Pharmaceutical Sciences

Asiatic acid, an active metabolite of asiaticoside, is one of the biological active triterpenoids in Centella asiatica. A single liquid-liquid extraction and high-performance liquid chromatographic (HPLC) method have been developed and validated for the ...


Spectrophotometric Determination Of Total Alkaloids In Some Iranian Medicinal Plants, Fazel Shamsa, Hamidreza Monsef, Rouhollah Ghamooshi, Mohammadreza Verdian-Rizi Jan 2008

Spectrophotometric Determination Of Total Alkaloids In Some Iranian Medicinal Plants, Fazel Shamsa, Hamidreza Monsef, Rouhollah Ghamooshi, Mohammadreza Verdian-Rizi

The Thai Journal of Pharmaceutical Sciences

A simple spectrophotometric method based on the reaction with bromocresol green (BCG) has been developed for determination of total alkaloids in medicinal plants. A yellow complex forms and is easily extractable by chloroform at pH 4.7. The absorbance of...


Antimicrobial Activity Of Endophytic Bacteria Isolated From Thai Medicinal Plant(ฤทธิ์ต้านจุลินทรีย์ของแบคทีเรียเอนโดไฟท์ที่แยกจากสมุนไพรไ..., Areerat Laorpaksa, Suree Jianmongkol, Wimon Pothiwong Jan 2008

Antimicrobial Activity Of Endophytic Bacteria Isolated From Thai Medicinal Plant(ฤทธิ์ต้านจุลินทรีย์ของแบคทีเรียเอนโดไฟท์ที่แยกจากสมุนไพรไ..., Areerat Laorpaksa, Suree Jianmongkol, Wimon Pothiwong

The Thai Journal of Pharmaceutical Sciences

Endophytic bacteria were isolated from internal plant tissues within four days of collections using a surface disinfected method. One hundred and six isolates from thirty five of Thai medicinal plants were cultured in either nutrient broth or nutrient br...


Mixing And Formulation Of Low Dose Drugs : Underlying Problems And Solutions, Vipin Kukkar, Vikas Anand, Mahesh Kataria, Manoj Gera, Pratim Kumar Choudhury Jan 2008

Mixing And Formulation Of Low Dose Drugs : Underlying Problems And Solutions, Vipin Kukkar, Vikas Anand, Mahesh Kataria, Manoj Gera, Pratim Kumar Choudhury

The Thai Journal of Pharmaceutical Sciences

Mixing and formulation of low dose drugs can be very challenging due to problems related to segregation, content uniformity and physical stability. A careful control on these factors is necessary while manufacturing low dose drug products. Selection of e...


Stability Evaluation Of Celecoxib Nanoemulsion Containing Tween 80, F. Shakeel, S. Baboota, A. Ahuja, J. Ali, M.S. Faisal, S. Shafiq Jan 2008

Stability Evaluation Of Celecoxib Nanoemulsion Containing Tween 80, F. Shakeel, S. Baboota, A. Ahuja, J. Ali, M.S. Faisal, S. Shafiq

The Thai Journal of Pharmaceutical Sciences

The aim of the present study was to evaluate the stability of celecoxib (CXB) using novel nanoemulsion formulation. Optimized nanoemulsion formulation of CXB was prepared by low energy emulsification method, stability studies were performed for the perio...


Preparation And Stability Of Butterfly Pea Color Extract Loaded In Microparticles Prepared By Spray Drying, Angkana Tantituvanont, Pornpen Werawatganone, Pacharaporn Jiamchaisri, Kasorn Manopakdee Jan 2008

Preparation And Stability Of Butterfly Pea Color Extract Loaded In Microparticles Prepared By Spray Drying, Angkana Tantituvanont, Pornpen Werawatganone, Pacharaporn Jiamchaisri, Kasorn Manopakdee

The Thai Journal of Pharmaceutical Sciences

Butterfly pea is one of the most interesting sources of natural color used in food and cosmetics. Anthocyanins are the main coloring compounds in its petals and could be extracted easily with water. The pH of medium, temperature, and light were found to ...


Author Index, Keyword Index, N/A Jan 2008

Author Index, Keyword Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Fast-Disintegrating Aceclofenac Tablets: Formulation Development Using Simplex Lattice, Garala Kevin C., Ekshinge Vinit, Jarag Ravindra, Shinde Anil J. Jan 2008

Fast-Disintegrating Aceclofenac Tablets: Formulation Development Using Simplex Lattice, Garala Kevin C., Ekshinge Vinit, Jarag Ravindra, Shinde Anil J.

The Thai Journal of Pharmaceutical Sciences

The poor aqueous solubility of the drug results เท variable dissolution profile and hence poor bioavailability. The aim of present work was to show the effect of various super disintegrants on the disintegration time and in vitro drug release rate. ...


Chemometrics-Assisted Spectrophotometric Determination Of Certain Β-Lactam Antibiotics Combinations, Abd El-Maboud I. Mohamed, Hesham Salem, Eman Maher Jan 2007

Chemometrics-Assisted Spectrophotometric Determination Of Certain Β-Lactam Antibiotics Combinations, Abd El-Maboud I. Mohamed, Hesham Salem, Eman Maher

The Thai Journal of Pharmaceutical Sciences

Multivariate and derivative spectrophotometric techniques (first derivative and derivative ratio) were developed for the determination of four p-lactam antibiotic binary mixtures; ampicillin with flucloxacillin (mix I), ampicillin with dicloxacillin (mix...


Effects Of Drying Temperature And Residual Moisture Content Of Fa-Tha-Li (Andrographis Paniculata (Burm.F.) Nees) Crude Powder For Capsule Preparation, Wipawee Saohin, Preecha Boonchoong, Supachai Lamlikitkuakoon, Itthichai Jamnoiprom, Wittaya Mungdee Jan 2007

Effects Of Drying Temperature And Residual Moisture Content Of Fa-Tha-Li (Andrographis Paniculata (Burm.F.) Nees) Crude Powder For Capsule Preparation, Wipawee Saohin, Preecha Boonchoong, Supachai Lamlikitkuakoon, Itthichai Jamnoiprom, Wittaya Mungdee

The Thai Journal of Pharmaceutical Sciences

The objectives of this research were to study the effects of drying temperature and residual moisture content on total lactones content calculated as andrographolide, flow ability and microbial contamination of Fa-Tha-Li (Andrographis paniculata (Burm.f....


Characterization Of Herpes Simplex Virus Type 1 Selected In Culture For Resistance To Acyclovir Or Foscarnet, Mali Wirotesangthong, Sakulrat Rattanakiat, Katsuhiko Matsui, Vimolmas Lipipun Jan 2007

Characterization Of Herpes Simplex Virus Type 1 Selected In Culture For Resistance To Acyclovir Or Foscarnet, Mali Wirotesangthong, Sakulrat Rattanakiat, Katsuhiko Matsui, Vimolmas Lipipun

The Thai Journal of Pharmaceutical Sciences

To determine the characteristics of herpes simplex virus type 1 (HSV-1) resistant to either acyclovir (ACV) or foscarnet (FOS), HSV-1 KOS (wild-type) strain was used for selection of drug-resistant mutants in Vero cells. เท one-step growth curve, all...


An Approach To Developing Dissolution Standards For Turmeric Capsules I: Basket Rotating Method, Nantana Sittichai, Sirichai Krabesri, Ekamol Suthison, Parkpoom Tengamnuay Jan 2007

An Approach To Developing Dissolution Standards For Turmeric Capsules I: Basket Rotating Method, Nantana Sittichai, Sirichai Krabesri, Ekamol Suthison, Parkpoom Tengamnuay

The Thai Journal of Pharmaceutical Sciences

A simple dissolution test and standard was developed for Turmeric capsules to replace the less discriminating disintegration test stated in the Supplement to Thai Herbal Pharmacopoeia 2004. The proposed test used the basket at 100 rpm and the dissolution...


Comparative Analysis Of Pharmaceutical Care And Traditional Dispensing Role Of Pharmacy, Phantipa Sakthong Jan 2007

Comparative Analysis Of Pharmaceutical Care And Traditional Dispensing Role Of Pharmacy, Phantipa Sakthong

The Thai Journal of Pharmaceutical Sciences

Pharmaceutical care is a new professional practice that can give an opportunity to pharmacists to prove themselves as a real health care profession. Pharmaceutical care practitioners are concerned with the outcomes of their services on patients’ life a...


Use Of A Dialyzable Short-Chain Phospholipid For Efficient Preparation Of Virosome Vaccines Against Newcastle Disease, Atthachai Homhuan, Sompol Prakongpan Jan 2007

Use Of A Dialyzable Short-Chain Phospholipid For Efficient Preparation Of Virosome Vaccines Against Newcastle Disease, Atthachai Homhuan, Sompol Prakongpan

The Thai Journal of Pharmaceutical Sciences

Virosomes can be regarded as liposomes carrying the spike proteins of enveloped virus on their surface. To further advance the use of virosomes, we developed a solubilization/ reconstitution procedure for construction of Newcastle disease (ND)-virosomes,...


28-Day Repeated Dose Oral Toxicity Study Of Litsea Cubeba Essential Oil In Sprague-Dawley Rats, Siraprapa Tubtim, Ake Wasiksiri Jan 2007

28-Day Repeated Dose Oral Toxicity Study Of Litsea Cubeba Essential Oil In Sprague-Dawley Rats, Siraprapa Tubtim, Ake Wasiksiri

The Thai Journal of Pharmaceutical Sciences

Litsea cubeba essential oil is a raw material source for the isolation of citral that can be converted to a number of important derivatives. This citral-rich essential oil is also increasingly used for flavour and fragrance applications in many household...


Author Index, Keyword Index, N/A Jan 2007

Author Index, Keyword Index, N/A

The Thai Journal of Pharmaceutical Sciences

No abstract provided.


Triterpenoids From The Stem Of Diospyros Glandulosa, Witchuda Thanakijcharoenpath, Orawan Theanphong Jan 2007

Triterpenoids From The Stem Of Diospyros Glandulosa, Witchuda Thanakijcharoenpath, Orawan Theanphong

The Thai Journal of Pharmaceutical Sciences

Six pentacyclic triterpenoids, including friedelin, β-amyrin, oleanolic acid, lupeol, betulin and ursolic acid, have been isolated from the stem of Diospyros glandulosa Lace. Identification of the isolated compounds was accomplished by analysis of their...


Hplc Determination Of Active Diterpene Lactones From Andrographis Paniculata Nees Planted In Various Seasons And Regions In Thailand, Chamnan Patarapanich, Suwanna Laungcholatan, Nuntakan Mahaverawat, Chaiyo Chaichantipayuth, Sunibhond Pummangura Jan 2007

Hplc Determination Of Active Diterpene Lactones From Andrographis Paniculata Nees Planted In Various Seasons And Regions In Thailand, Chamnan Patarapanich, Suwanna Laungcholatan, Nuntakan Mahaverawat, Chaiyo Chaichantipayuth, Sunibhond Pummangura

The Thai Journal of Pharmaceutical Sciences

A quantitative determination of four known diterpene lactone compounds : dehydroandroghapholide (C-2), andrographolide (C-3), neoandrographolide (C-4) and deoxyandrographolide-19-p-D glucoside (C-5) from the leaves of Andrographis paniculata, Nees. has b...


Samambaia - The Future Focus For Indian Researchers In The Treatment Of Psoriasis, Kuntal Das, John Wiiking Einstein Jan 2007

Samambaia - The Future Focus For Indian Researchers In The Treatment Of Psoriasis, Kuntal Das, John Wiiking Einstein

The Thai Journal of Pharmaceutical Sciences

Psoriasis is an issue of global and national public health concern. The traditional use of medicinal plants to treat this disease is widespread throughout India. The present review is an attempt for the beneficial effect of the South American originated ...


Cytotoxicity And Inhibitory Activity On Hepatitis B Surface Antigen Secretion From Plc/Prf/5 Cells Of Medicinal Plant Extracts, Thaveechai Prommetta, Sattaporn Sirotamarat, Kruavon Balachandra, Ekarin Saifah Jan 2006

Cytotoxicity And Inhibitory Activity On Hepatitis B Surface Antigen Secretion From Plc/Prf/5 Cells Of Medicinal Plant Extracts, Thaveechai Prommetta, Sattaporn Sirotamarat, Kruavon Balachandra, Ekarin Saifah

The Thai Journal of Pharmaceutical Sciences

Ethanolic extracts of three medicinal plants including Derris scandens, Rhinacanthus nasutus and Santalum album were investb'ated for cytotoxicity by MTT assay and inhibition of hepatitis B surface antigen secretion from PLC/PRF/5 cells by ELISA. Results...


Aqueous Extract Of The Calyces Of Hibiscus Subdariffa Linn.: Effects On Hepatic Cytochrome P450 And Subacute Toxicity In Rats, Promphorn Wirotesangthong, Laddawal Phivthong-Ngam, Chaiyo Chaichantipyuth, Nuansri Niwattisaiwong, Somsong Lawanprasert Jan 2006

Aqueous Extract Of The Calyces Of Hibiscus Subdariffa Linn.: Effects On Hepatic Cytochrome P450 And Subacute Toxicity In Rats, Promphorn Wirotesangthong, Laddawal Phivthong-Ngam, Chaiyo Chaichantipyuth, Nuansri Niwattisaiwong, Somsong Lawanprasert

The Thai Journal of Pharmaceutical Sciences

Hibiscus sabdariffa Linn, has been reported to have a broad range of therapeutic effects. Subacute effects of the calyces of H. sabdariffa aqueous extract on the activities of cytochrome P450 (CYP), clinical blood chemistry and hematology were investigat...


Antioxidant Activity, Phenolic Compound Contents And Antimutagenic Activity Of Some Water Extract Of Herbs, Kalyarat Mekaroonreung, Kaew Kangsadalampai Jan 2006

Antioxidant Activity, Phenolic Compound Contents And Antimutagenic Activity Of Some Water Extract Of Herbs, Kalyarat Mekaroonreung, Kaew Kangsadalampai

The Thai Journal of Pharmaceutical Sciences

Ten water extracts from herbs were prepared by boiling in hot water for 10 min. The herbal extracts were studied for their antioxidant activity and phenolic compound contents. In this study, the extracts of C arthamus tinctorius L, Hibiscus sabdariffa L,...