Pharmacology, Toxicology and Environmental Health Commons^™

Enhancing Access To Alcohol Use Disorder Pharmacotherapy And Treatment In Primary Care Settings: Adapt-Pc., Hildi J Hagedorn, Randall Brown, Michael Dawes, Eric Dieperink, Donald Hugh Myrick, Elizabeth M Oliva, Todd H Wagner, Jennifer P. Wisdom, Alex H S Harris

Health Policy and Management Faculty Publications

BACKGROUND: Only 7.8 % of individuals meeting diagnostic criteria for alcohol use disorder (AUD) receive treatment in a given year. Most individuals with AUDs are identified in primary care (PC) settings and referred to substance use disorders (SUD) clinics; however, only a minority of those referred attend treatment services. Safe and effective pharmacological treatments for AUD exist, but they are rarely prescribed by PC providers. The objective of this study is to refine, implement, and evaluate an intervention to integrate pharmacological AUD treatment options into PC settings. This paper provides a detailed description of the intervention design and the evaluation …

Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura Wise, Alan L. Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter

Journal Articles

The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. The adverse effects of clozapine, including agranulocytosis, make finding a safe clozapine-like a drug a goal for drug developers. The drug dis- crimination paradigm is a model of interoceptive stimulus that has been used in an effort to screen experimental drugs for clozapine-like atypical antipsychotic effects. The present study was conducted to elucidate the receptor-mediated stimulus properties that form this clozapine discriminative cue by testing selective receptor ligands …

Medical Interns', Residents' And Attending Physicians' Attitudes Towards Integrative Medicine And Recommended Treatments For Patients With Psoriasis, Jennifer L. Pacyon

PCOM Psychology Dissertations

Background: Psoriasis is a multifactorial disease that effect approximately 7.5 million Americans. There are a variety of traditional treatments for psoriasis (e.g. topical medications, biologics) that for many, are effective in combating the disease. However, traditional treatments often have aversive side effects and may not be appropriate for every patient (e.g. pregnant women). Additionally, the efficacy of these medications are variable leaving some looking for adjunctive treatment options. There is increasing evidence to support the use of adjunctive treatments for psoriatic patients (e.g. psychotherapy, mindfulness). However, research is variable in regards to medical professionals’ attitudes towards integrative medicine (IM) as …

An Ecotoxicological Survey Of Tributaries Of The Selenge River, Mongolia, August 2010, Viktor T. Komov, Ch. Javzan, William G. Brumbaugh

Erforschung biologischer Ressourcen der Mongolei / Exploration into the Biological Resources of Mongolia, ISSN 0440-1298

The biodiversity of the Selenga river basin and the receiving waters of the lake Baikal, are among the greatest in the world with over 1,700 known endemic species of plants and animals. Mining activities along the Selenga river and its tributaries pose a major threat of chemical contamination, potentially reducing habitat quality and suitability for aquatic species. Moreover, the Selenga river serves as a major water source for the lake Baikal. Little information exists on the chemical contaminant concentrations in the Selenga river basin. Thus, the objectives of our study were to evaluate the concentrations of metals in soil, sediment, …

A Glimpse At Media-Framing Effects On Place Attachment In Rural Northwest Montana, Gregory D. Bruns

Communication & Leadership Dissertations and Theses

This study examined how outdated media framing can disturb rural place attachment. Evaluating this concept against the backdrop of south Lincoln County, Montana, which is nearing the end of a years-long EPA Superfund cleanup, over 100 regional visitors were surveyed to learn if media framing affected place-attachment sentiments. The investigation revealed that existing news stories, some up to 15 years old, may be playing a lingering and consequential role in attracting first-time destination seekers to the region, in support of framing theory. Furthermore, these findings also lend credence to the significance of sound Internet search-engine optimization practices, and provide an …

Acute And Chronic Effects Of Inhalants In Intracranial Self-Stimulation, Matthew Tracy

Theses and Dissertations

Inhalants are a loosely defined diverse group of volatile substances which people abuse. Despite widespread misuse of inhalants, there are limited preclinical methods available to study the reinforcement-like properties of inhalants. One procedure which has demonstrated substantial promise as a tool to investigate inhalant pharmacology is the intracranial self-stimulation (ICSS) procedure. ICSS utilizes pulses of electrical stimulation to the mesolimbic reward pathway to serve as a temporally defined and controlled operant reinforcer with a highly adjustable efficacy. The first aim of the project was to characterize the effects of commonly abused inhalants: including toluene, trichloroethane, nitrous oxide, isoflurane and R134a …

Consequences Of Developmental Lead (Pb2+) Exposure On Reproductive Strategies In Drosophila, Elizabeth Kathleen Peterson

Legacy Theses & Dissertations (2009 - 2024)

Anthropogenic lead (Pb) pollution is ubiquitous in the environment and a risk factor for both human and wildlife health. Pb exposure has the potential to alter reproductive strategies with respect to mate choice and reproductive output. This could be especially deleterious if these changes disrupt adaptive behavioral and reproductive life history strategies. Therefore, the overall aim of this body of work was to examine the consequences of developmental Pb exposure on reproductive strategies, using Drosophila melanogaster as a model system. In all experiments, D. melanogaster were reared from egg stage to adulthood in either control or leaded medium and were …

Corporate Social Responsibility/Sustainability Reporting Among The Fortune Global 250: Greenwashing Or Green Supply Chain?, John K. Lewis

Faculty and Staff - Articles & Papers

The sustainability reporting efforts of MNCs who are members of the Fortune Global 250 (FG250) was investigated. The focus was on sustainability reporting by MNCs of supply chain impacts. The reporting of FG250 MNCs was examined to determine if greenwashing was occurring or whether MNCs had committed to operating a green supply chain. A mixed methodology was used consisting of quantitative analysis of twenty-five MNC CSR/sustainability reports which were randomly selected from the FG250 listing. Qualitative analysis using content analysis was also conducted on the reports. Both methodologies concentrated on the sustainability reporting of the selected MNCs in regard to …

The Role Of The State, Multinational Oil Companies, International Law & The International Community: Intersection Of Human Rights & Environmental Degradation Climate Change In The 21st Century Caused By Traditional Extractive Practices, The Amazon Rainforest, Indigenous People And Universal Jurisdiction To Resolve The Accountability Issue, Marcela Cabrera Luna

Master's Theses

Local, national and international conventions that protect indigenous sovereignty and their territories, where many of the resources are extracted from by multinational corporations (MNCs) particularly oil, the number one commodity of the world and cause of climate change, continue to be jeopardized because of the lack of a clear international legal framework that can protect them and potentially hold multinationals accountable for their actions. These practices are causing not only environmental issues to the indigenous and surrounding communities, but climate change is in fact, the real human rights issue of the 21^st century and it affects everyone. By using …

Impact Of Executive Order 13211 On Environmental Regulation: An Empirical Study, Elizabeth Ann Glass Geltman

Publications and Research

A great deal has been written about the Energy Policy Act of 2005 exempting oil and gas operations using hydraulic fracturing from the purview of certain federal environmental laws. Far less attention has been paid to George W. Bush’s Executive Order 13211 (EO 13211), entitled “Actions Concerning Regulations that Significantly Affect Energy Supply, Distribution or Use.” The executive order requires federal agencies to evaluate the impact of federal regulations on “supply, distribution and use of energy.” This study examined the impact of EO 13211 on United States environmental and conservation regulations proposed and promulgated by federal agencies. The study found …

Recursos Y Servicios Disponibles Para Personas Afectadas Por El Uso De Agroquímicos Tóxicos En Avia Terai, Chaco, Argentina / Resources And Services That Are Available To People Who Are Affected By The Use Of Toxic Agrochemicals In Avia Terai, Chaco, Argentina, David Andersen

Independent Study Project (ISP) Collection

Introducción: El Chaco es una provincia del norte de Argentina con los peores indicadores de salud y de menor ingreso. El estudio se desarrolló en Avia Terai, un pueblo que tiene cinco mil habitantes, está rodeado por cultivos que son fumigados con agroquímicos tóxicos y que tiene niveles muy altos de cáncer y de discapacidad. Muchas personas en Avia Terai trabajan con agroquímicos y viven cerca de los campos fumigados. La mayoría de las personas en el pueblo no tienen seguros de salud y usan el sector público. En el pueblo hay un Centro Integrador Comunitario (CIC), un hospital, dos …

Effects Of Nicotine On A Translational Model Of Working Memory, David Alderson Macqueen

USF Tampa Graduate Theses and Dissertations

Cognitive research with human non-smokers has demonstrated that nicotine generally enhances performance on tasks of attention but, working memory does not appear to be affected. In contrast, nicotine has been shown to produce robust enhancements of working memory in non-human animals. To address this disparity, the present study investigated the effects of nicotine (2mg, 4mg nicotine gum, and placebo) on the performance of 30 non-smokers (15 male) completing a working memory task developed for rodents (the odor span task, OST). Nicotine has been reported to enhance OST performance in rodents and the present study sought to determine whether the effect …

Using Choice Experiment Valuation Methods To Measure Public Preference For A New National Park In Maine, Alexander G. Wilsterman

Journal of Environmental and Resource Economics at Colby

With global population increasing faster than ever, the need to protect land from development is at an all-time high. This paper seeks the measure the public preference for a new national park located in northern Maine. A national park will both protect the land and inject a much-needed economic stimulus to the surrounding communities. The study uses the choice experiment valuation method to quantify its results. Through this revealed preference we can quantify which characteristics are most important to the public so that these characteristics may be considered if the project is ever approved.

Golf Courses In Maine: Land Type Valuation Versus A Hedonic Pricing Analysis, Gregory Ladd, Jason Buco

Journal of Environmental and Resource Economics at Colby

Many studies have been conducted analyzing the economic impact of golf courses on the local communities. These studies examine economic impacts of tournaments, endorsements, and vacation expenses of the major golf courses in the United States. However, there is little research conducted on the environmental impact of Golf courses, specifically in Maine. This paper performs a hedonic pricing analysis using housing prices in proximity to golf courses and compares it to the valuation of various land types in Maine. Housing prices were collected in the towns of Auburn, and North Yarmouth both near and distant from the local golf course. …

Cost Benefit Analysis Of Café Standards Compared To The Alternative Fuel/Carbon Tax, Brian Levinson

Journal of Environmental and Resource Economics at Colby

The Cafe Standards were introduced in 1975 following the Oil Embargo. The goals of this program were simple. To reduce co2 emissions in vehicles by increasing a mandatory average mpg level for car manufacturers in the United States. Recently, in 2012, the Obama Administration set new Cafe Standard requirements for car manufacturers. By 2025, all new cars on the road in the United States must average 54.5 miles per gallon, which would double the current 27 mpg average in place right now. While the intentions of this policy are to reduce co2 emissions while at the same time increasing savings …

The Economics Of The Audubon Society's Sanctuary Program For Golf Courses, Dan Hyszczak

Journal of Environmental and Resource Economics at Colby

Millions of people play golf every year, and in 2011 Golf Courses gained $22 billion dollars in revenue. This statistic combined with golf’s inherent place in the natural environment lead to questions of value and development for golf course owners. In 1991, The Audubon Society created their Cooperative Sanctuary Program for Golf Courses (ACSP) to promote environmentally sustainable practices for golf courses and to recognize the courses that are the most environmentally in both the United States and around the world.

This paper builds off of prior research that connects golf course beauty with revenue by examining the effects of …

Preferences For Coral Reef And Fishery Management In Okinawa, Japan, Nils Carlson

Journal of Environmental and Resource Economics at Colby

This study is an example of how a nonmarket valuation method – a choice experiment – can be used to influence and guide ecosystem conservation efforts. Using a choice experiment survey, this study estimates the willingness to pay (WTP) for certain hypothetical attributes of a restored and conserved coral reef in Okinawa, Japan. I find that an increase in the amount of fish available to catch in ten years as well as an increase in the extent and health of the coral reefs and the number of marine biodiversity found in the Okinawan waters after ten-years, both positively affect respondent’s …

An Exploratory Statistical Analysis Of The External And Internal Effects Of Art Museums In The United States, John Eder

Journal of Environmental and Resource Economics at Colby

An Exploratory Statistical Analysis of the External and Internal Effects of Art Museums in the United States

A Survey On Climate Change: How Beliefs Shape Responsibility, Connor P. Clancy, Sarah Beth Solomon

Journal of Environmental and Resource Economics at Colby

This paper examines the lack of awareness and feelings of personal responsibility for climate change. Previous literature suggests that while part of the United States population may be aware of climate change, they do not feel personally responsible for causing it despite feeling climate change’s effects just like everyone else. Furthermore, studies suggest that individuals also do not believe climate change will affect them now, but rather it is an issue for future generations. Using a survey, we examine which demographics and personal factors are most important in eliciting awareness for climate change, and furthermore, personal responsibility for its effects. …

Invited Introduction To Jerec, Noelwah Netusil

Journal of Environmental and Resource Economics at Colby

No abstract provided.

Welcome By The Editor, Sahan T. M. Dissanayake

Journal of Environmental and Resource Economics at Colby

No abstract provided.

An Analysis Of The Interaction Of Methylphenidate And Nicotine In Adolescent Rats: Effects On Bdnf, Elizabeth D. Freeman

Electronic Theses and Dissertations

This investigation was an analysis of the interaction of adolescent exposure to methylphenidate (MPH; trade name: Ritalin) on nicotine sensitization and conditioned place preference (CPP) in a rodent model and underlying mechanisms of this effect. Animals were treated IP with 1 mg/kg MPH or saline using a ―school day‖ regimen of five days on, two days off, from postnatal day (P) 28-50. During the final two weeks of MPH treatment, animals were either behaviorally sensitized to nicotine (0.5 mg/kg free base) or saline for 10 days, or conditioned to nicotine or saline using the CPP behavioral paradigm. In addition, three …

Impacts Of Consumer Horticulture On Stormwater And Nutrient Management: Investigating Public Perception, Knowledge, And Practices In The Shenandoah River Watershed, Christopher P. Parker

Masters Theses, 2010-2019

The South Fork Shenandoah River is a tributary to the Chesapeake Bay that is a significant contributor to nitrogen and phosphorus that enter the Bay and leads to increased eutrophication. These nutrients also cause problems in the South Fork Shenandoah River. The United States Environmental Protection agency has implemented strict regulation to reduce nutrients entering the Bay by developing the Chesapeake Bay TMDL. While the TMDL has strict regulation on wastewater treatment, agriculture, and industry, there are still sources of nutrients entering the Bay through unregulated sources. Urban/suburban runoff is one of these sources, particularly runoff from home owner’s lawns. …

How Does The Exploitation And Degradation Of Finite Natural Resources By Industrial Oil Producers Effect Our Future Planetary Environment?, Zachary J. King Mr.

Symposium of Student Scholars

Zachary King

Dr. Tu

26 March 2015

GEOG 3700

Abstract

The purpose of this presentation is to communicate content of the reports given by credible institution on the degradation and exploitation of finite natural resources by corporate institutions, for short term financial gain, and how it will effect the future planetary environment. Methods used in obtaining this research range from point source observation directly from oil spills in the Gulf or pipe leaks in the Mid-West, to analytical and numerical data quantifications gathered over a period of two decades. This presentation encompasses a wide scope of information concerning the way …

Marine Animalia Organism Diversity And Reef Condition On Two Reef Sites At Big Creek Beach And Boca Del Drago, Bocas Del Toro, Panamá, Bri Tiffany

Independent Study Project (ISP) Collection

Ocean acidification, climate change, overfishing, and coastal development are endangering coral reefs across the globe. In Bocas del Toro, Panamá, coral reefs are especially threatened by the rapid growth in tourism and the subsequent anthropogenic effects caused by an increased human presence. To evaluate reef condition in this area, a study comparing percent coverage of live and dead coral as well as the diversity of marine Animalia organisms was conducted at one reef site in Big Creek beach and one reef site in Boca del Drago, Isla Colón, Bocas del Toro. It was predicted that dead coral cover would be …

Comparing Avian Diversity And Anthropogenic Disturbance At Sendero Los Quetzales Cerro Punta, Panamá, Sloane Merdinger

Independent Study Project (ISP) Collection

This report summarizes the survey of land and avian diversity along a transect that runs from the exterior to the interior of the Los Quetzales Trail of Parque Nacional Volcán Barú in Cerro Punta, Chiriquí, Panamá. The region of Cerro Punta is Panamá’s primary producer of produce and also home to one of the most biodiverse land reserves in the world. Despite protection efforts the area is continuously threatened by human development. The study juxtaposes calculated Shannon-Wiener Biodiversity Indices across graduated levels of anthropogenic disturbance to determine if there is a significant difference in biodiversity between areas with low, intermediate, …

Elucidation Of Pharmacologically Manipulated Responding In The Delay Discounting Task In High Alcohol Preferring Mice, Meredith Halcomb

Open Access Dissertations

Impulsive behavior is the hallmark of many psychopathologies. Uncovering the neurobiological mechanisms driving impulsivity is paramount in the development of through the delay discounting (DD) task in both human and animal models. The present study is an examination of the predictive validity of the two primary types of DD procedures in animals, the Adjusting Amounts (AA) and within session Increasing Delays (ID) tasks. Methods:Subjects were administered either1.25 mg/kg d-amphetamine (AMP), 1.5 g/kg ethanol (EtOH) or saline and tested in either the AA or ID method for 15 days to evaluate drug effects on impulsive behavior. Results: Stimulant administration resulted …

Fish Use Of Largely Unexplored Sub-Tidal Habitats In The Hinchinbrook Channel Estuary, Queensland, Alexandra Parisien

Independent Study Project (ISP) Collection

This study examines the use of sub-tidal open-bottom, rocky, and seagreass habitats by the Siganus genus (herbivores), Gerres genus (benthivores), and planktivores in the Hinchinbrook Channel Estuary in Queensland, Australia. The Hinchinbrook Channel Estuary, a tropical estuary cutting between Hinchinbrook Island and the Australian mainland, is surrounded primarily by mangroves. Its sub-tidal habitats are largely unexplored due to factors such as low visibility and the presence of estuarine crocodiles. In this study, I reviewed 699 underwater videos collected by James Cook University PhD candidate Michael Bradley in order to analyze feeding and movement behavior of pre-identified fish.

The results of …

Soil Total Organic Carbon And Farmers’ Perceptions Associated With Bokashi Application In Cerro Punta, Panama, Emma Searson

Independent Study Project (ISP) Collection

Sustainable use and maintenance of agricultural soils are important for maintaining long-term agricultural productivity and environmental quality. These issues are especially important in Cerro Punta, known as the breadbasket of Panama, which is experiencing severe erosion. While current practices and agrochemical usage damage soil health and function over time, application of organic material improves soil physic-chemical properties such as nutrient and total organic carbon (TOC) content. Bokashi, a fermented organic soil amendment with effective microorganisms (EM), is thought to be especially beneficial due to its ability to augment populations of soil microbes, which deliver plant-available nutrients to crops and improve …

Waste Management And Environmental Initiatives In Accra, Ghana, Aoife Genevieve Duna

Independent Study Project (ISP) Collection

Title: Waste Management and Environmental Initiatives in Accra, Ghana

Author: Aoife Genevieve Duna ([email protected]; Middlebury College, Anthropology and Dance major)

Objective: The objective of this project was fourfold: • To study the current waste management practices by government and private waste companies • To observe the perspectives of residents on waste disposal • To explore environmental initiatives by citizens, NGOs, and student groups • To investigate the potential projects that could reduce waste

Methodology: For my project, I conducted interviews, made observations, participated in daily personal waste management, visited a landfill, and visited a composting project.

Findings: Waste collection is …