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Articles 1 - 30 of 253
Full-Text Articles in Other Life Sciences
The Effect Of Sustainable 3d Store Design On Consumer Online Shopping Behavior, Sophie G. Roussel
The Effect Of Sustainable 3d Store Design On Consumer Online Shopping Behavior, Sophie G. Roussel
Apparel Merchandising and Product Development Undergraduate Honors Theses
Sustainability has become a significant factor in shaping consumer shopping habits. Companies are implementing 3D store designs to provide a more immersive and interactive experience. Further study is needed to investigate whether a sustainable, green-focused 3D storefront shifts consumers’ satisfaction with online shopping and their intention to buy products from a sustainable store. This study seeks to fill the research gap by examining how sustainable 3D store design influences consumer shopping behavior. Specifically, three distinct 3D store mockups were developed using Visual Retailing (VR) technology. The same number of visually appealing features, products, and store layouts was used to make …
Supramolecular Assembly In Short Peptide Systems For Selective Metabolite Recognition And Drug Nanoencapsulation, Maithreyi Ramakrishnan
Supramolecular Assembly In Short Peptide Systems For Selective Metabolite Recognition And Drug Nanoencapsulation, Maithreyi Ramakrishnan
Dissertations, Theses, and Capstone Projects
Short peptides can form adaptive supramolecular assemblies, and understanding how minimal sequences organize around neurometabolites or hydrophobic cancer drugs enables the rational design of functional materials. This thesis combines molecular dynamics with experimental validation to establish design rules linking peptide sequence to emergent structure and function. Chapter 1 outlines the molecular determinants governing peptide assembly. Chapter 2 reviews computational workflows that reveal sequence-dependent conformations and supramolecular organization. Chapter 3 applies these principles to Dynamic Peptide Libraries which identify tetrapeptides that selectively interact with neurometabolites. Chapter 4 extends the same interaction-driven framework to design tryptophan-rich pentapeptides that co-assemble with kinase inhibitors …
Beat Behind The Bark: Investigating The Effects Of Music Tempo On Canine Physiological And Psychological States, Marley Lanier
Beat Behind The Bark: Investigating The Effects Of Music Tempo On Canine Physiological And Psychological States, Marley Lanier
Honors Theses
This study explores how the tempo of music, measured in beats per minute (BPM), affects dogs' heart rate and oxytocin levels, adding to past research that shows that music affects physiological and behavioral states in dogs. Being able to understand these effects holds practical implications for improving overall well-being in canines in environments such as homes, shelters, and clinical environments. Using a within-subjects design, the dogs were exposed to slow and fast versions of one instrumental track, along with a white noise baseline condition before each randomized condition. Heart rate was recorded continuously throughout the session, and oxytocin saliva samples …
Evaluating Fungal Endophytes Inoculation As A Mechanism For Salt Tolerance In Juncus Roemarianus, Rani Badve
Evaluating Fungal Endophytes Inoculation As A Mechanism For Salt Tolerance In Juncus Roemarianus, Rani Badve
Honors Theses
Salinity stress is increasing in coastal and estuarine ecosystems due to increasing temperatures and the reduction of freshwater inputs via precipitation pattern changes. Elevated salinity can negatively affect plant survival, threatening the stability of coastal wetlands and the ecosystem services they provide. Juncus roemerianus is a common and dominant marsh plant in the Northern Gulf Coast that lives in varying salinities. Growing evidence suggests that root-associated fungal endophytes may contribute to enhanced stress tolerance; however, the response of fungal communities to salinity remains poorly understood.
This study evaluated how salinity influences the abundance and diversity of culturable root-associated fungal communities …
The Impact Of Label Material On Perceived Value And Environmental-Friendliness Of Beverages In Returnable Glass Bottles Versus Actual Environmental Impact Via Life Cycle Assessment, Toni Sharp
All Dissertations
With guidance from the EPA to reduce virgin packaging use and alternatively increase reuse, the concept of reusable packaging has re-emerged as a potential sustainable alternative to single-use and recyclable packaging. For businesses, an understanding of the potential environmental benefits of switching from single-use packaging to reusable packaging, along with consumer willingness to pay for sustainable packaging are paramount. Existing literature on willingness to pay (WTP) for ethical or sustainable products typically relies on consumers’ stated preferences found through surveys using hypothetical products and prices. It has been revealed that sustainability claims printed on the label or products in glass …
Feeding Ecology In Coastal Systems, Randi L. Cannon
Feeding Ecology In Coastal Systems, Randi L. Cannon
Graduate Theses and Dissertations (2019 - present)
Oysters (Crassostrea virginica) are critical foundation species in estuaries, providing numerous ecological and economic benefits. However, oyster populations have diminished worldwide. Effective oyster restoration and aquaculture require a mechanistic understanding of the physiological and environmental factors that govern oyster feeding, growth, and resilience under changing coastal conditions. We investigated how oyster ploidy and environmental conditions influenced oyster feeding and investigated how changes in abiotic conditions affected behavioral performance of oyster drills (Stramonita spp.), a key oyster predator. To better understand feeding responses and behaviors of both predator and prey we 1) used in-situ filter feeding assays to determine if feeding …
Tips For Health Care Practitioners: A Guide For Adolescent Obesity, Regina Santana
Tips For Health Care Practitioners: A Guide For Adolescent Obesity, Regina Santana
Electronic Theses, Projects, and Dissertations
Adolescent obesity continues to be a significant public health concern that is associated with long term physical consequences. The purpose of this project was to develop an evidence based, user friendly guidebook that supports healthcare professionals in the education of adolescents with obesity and their families. A structured literature review development process was used to inform the current development of the guidebook. The guidebook includes components of obesity management such as nutrition and physical activity recommendations. The validity of the content was established through the evaluation of five healthcare professionals that include registered dietitians and licensed therapists. The guidebook was …
Curriculum For A Two Semester Calculus Course Specializing In Life Science And Data Science, Patrick Mcclain
Curriculum For A Two Semester Calculus Course Specializing In Life Science And Data Science, Patrick Mcclain
LSU Master's Theses
Traditionally, introductory calculus has been designed for engineering and physics students, often leaving students majoring in data science or life sciences with a curriculum that lacks professional relevance and is overly reliant on problems that focus on computational fluency. This thesis proposes a two-semester sequence, called MATH 153X and MATH 154X, specifically tailored for the Louisiana State University (LSU) Dual Enrollment program and university-level data science and life sciences majors. By integrating modern computational tools—such as symbolic calculators and artificial intelligence (AI) tools—the proposed curriculum shifts the pedagogical focus from procedural symbolic manipulation toward conceptual literacy.
Through a series …
Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr
Jackfruit Peel Valorization Through An Integrated Biorefinery Approach, Rohil Kumar K Mr
Theses and Dissertations
Jackfruit (Artocarpus heterophyllus) peel (JFP), an abundantly available lignocellulosic biomass, remains largely underutilized despite being rich in cellulose, hemicellulose, lignin, and pectin. In India, approximately 13,460 hectares are under jackfruit cultivation, with Panruti in Tamil Nadu as a major production zone. The discarded peel often contributes to environmental pollution and greenhouse gas emissions. The present study emphasizes sustainable valorization of JFP through an integrated biorefinery framework for generating value-added bioproducts.
Major biopolymers, cellulose, hemicellulose, lignin, and pectin were extracted and fractionated, followed by detailed physicochemical characterization using FTIR, NMR, XRD, SEM, TGA, DSC, GPC, and BET analyses. Pectin extraction with …
Exploration Of The Use Of Radiocarbon Time-Series Records As Indicators Of Upwelling Areas, Rena Reshmi Mukherjee
Exploration Of The Use Of Radiocarbon Time-Series Records As Indicators Of Upwelling Areas, Rena Reshmi Mukherjee
CMC Senior Theses
The Earth’s oceans buffer climate change, regulate weather patterns, sustain global food security, and support biomedical research. Ocean currents redistribute heat and nutrients while promoting genetic diversity, which can serve as a source of novel compounds for biomedical research. Understanding ocean circulation is essential for maintaining these ecosystem services as the climate continues to change. Upwelling, a form of vertical water movement that transports nutrient-rich deep water to the surface, plays a key role in marine productivity and carbon cycling. However, global upwelling patterns remain incompletely mapped. Radiocarbon (14C), a radioactive isotope of carbon, provides a useful tracer of ocean …
Feasibility Of Corn Stover For Biogas Production In Northwestern Illinois: A Case Study Of Jo Daviess And Carroll Counties, Anthony Amotoe-Bondzie
Feasibility Of Corn Stover For Biogas Production In Northwestern Illinois: A Case Study Of Jo Daviess And Carroll Counties, Anthony Amotoe-Bondzie
Masters Theses
The growing demand for renewable energy and sustainable waste management has intensified interest in agricultural residues such as bioenergy feedstocks. This study evaluated the feasibility of converting corn stover into biogas through anaerobic digestion (AD) in Jo Daviess and Carroll Counties, Illinois, with consideration of the Savanna Industrial Park as a potential centralized processing hub. Although corn stover represents one of the largest biomass resources in the United States, this research identifies a critical gap between theoretical availability and practically recoverable feedstock. Using a mixed-methods framework, the study integrates biomass quantification, methane yield modeling, economic analysis, and policy assessment. Results …
Development Of The Core Lit Apparatus For Seaweed Hatcheries (Clash) Bioreactor Using A Germplasm Approach, Phillip O. Tahimic
Development Of The Core Lit Apparatus For Seaweed Hatcheries (Clash) Bioreactor Using A Germplasm Approach, Phillip O. Tahimic
Cal Poly Humboldt theses and projects
In comparison to the Asian aquaculture industry, the United States has minimal seaweed production. There are several drivers of the limited industry in the US, such as regulatory constraints and limited market demand, but the ability to scale is a considerable barrier to commercialization. One possible solution is the development of land-based systems that integrate bioreactors, which utilize fewer resources and do not wholly rely on an oceanic flow-through system. This study assessed the application of a modular bioreactor, known as Core Lit Apparatus for Seaweed Hatcheries (CLASH), as a nursery system and open-source project designed to expand land-based seaweed …
The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss
The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss
Honors Undergraduate Theses
Resistance training serves as a critical non-pharmacological strategy for mitigating the physiological and psychological declines associated with the menopausal transition. This natural biological phase, marked by declining estrogen levels, typically leads to accelerated bone mineral density loss, sarcopenia, metabolic regulation disturbance, and heightened mood disturbances. To evaluate the efficacy of targeted exercise interventions, a systematic review was conducted following PRISMA guidelines. From an initial pool of 60 relevant articles, 13 studies met the specific inclusion criteria, focusing on structured resistance training protocols for perimenopausal, menopausal, and postmenopausal cohorts.
The synthesis of these studies indicates that resistance training is a highly …
Effects Of Volatile Organic Compounds Produced By Temperature-Adapted Microbes On Duckweed Growth, Phaedra Yael Stemp
Effects Of Volatile Organic Compounds Produced By Temperature-Adapted Microbes On Duckweed Growth, Phaedra Yael Stemp
Honors Theses and Capstones
As host-associated microbes adapt to their abiotic environment, these adaptations can affect their host species as well. Previous research showed that varying temperatures and volatile organic compound (VOC) production can affect microbial benefits to hosts. This experiment analyzed how 27 microbes pre-adapted to different temperature conditions affected growth of their host, common duckweed plants, comparing effects of direct contact with microbes, effects of microbe VOCs alone, or both. Each microbe was pre-adapted to one of three temperature regimes: “Northern” at 28 °C, “Southern” at 33 °C, and “Extreme” at 36 °C. We then grew duckweeds in I-plates with each microbe …
What’S That Smell? It’S Climate Change!, Perry Gregory
What’S That Smell? It’S Climate Change!, Perry Gregory
Capstones
Climate change is going to make New York City smell worse. Reporter Perry Gregory breaks down the process of olfaction and explains how heat affects what we smell. The piece features a collage of voices of New Yorkers describing the current smell profile of the city. The report features insight from several Atmospheric Scientists into why New York City is getting hotter and more humid, and how those climate changes will make the existing smells of the city stronger, and worse. The most economically vulnerable New Yorkers, who cannot afford air conditioning to buffer them from heat, will be the …
A Geological And Geochemical Study Of The Philipsburg Mining District, Granite County, Montana, Celine M. Beaucamp
A Geological And Geochemical Study Of The Philipsburg Mining District, Granite County, Montana, Celine M. Beaucamp
Graduate Theses & Non-Theses
The Philipsburg district, renowned for its rich mining history, has contributed significantly to Montana's mineral production, ranking as the state's second-most productive district. Active from 1865 to the 1980s, it yielded an impressive array of Ag (50-60 million oz), with notable outputs of Au, Zn, Pb, Cu, and battery-grade MnO2. The district features Cordilleran polymetallic veins, some of which are along bedding in Mississippian and Devonian limestone, and others are steeply dipping quartz veins in silicate-rich sedimentary rocks and in the Philipsburg batholith. The veins exhibit a district-wide mineral zonation, marked by Cu- and Ag-rich ores near granite porphyries, with …
Aqueous Geochemistry Drives Microbial Cu, Fe, And Zn Uptake Rates In Yellowstone, A Continental Hydrothermal System, Eva Carolina Andrade-Barahona
Aqueous Geochemistry Drives Microbial Cu, Fe, And Zn Uptake Rates In Yellowstone, A Continental Hydrothermal System, Eva Carolina Andrade-Barahona
Graduate Theses & Non-Theses
Microbial uptake of trace metal cofactors such as copper (Cu), iron (Fe), and zinc (Zn) is governed by biogeochemical processes in hydrothermal systems where metal bioavailability varies widely. In situ microbial metal uptake rates were quantified by applying metal stable isotope probing (MSIP) in the Yellowstone hydrothermal system across diverse geochemical conditions in hydrothermal springs. The findings in these studies revealed that pH exerts a dominant influence on microbial copper uptake rate, also enhanced by increased Cu²⁺ ion availability and dissolved oxygen. Microbial iron uptake, in contrast, displayed a broad tolerance to environmental variability, occurring across a pH range of …
Development Of Microcrystalline Tests For Fentanyl, Clonazepam, And Diazepam Identification, Karis French
Development Of Microcrystalline Tests For Fentanyl, Clonazepam, And Diazepam Identification, Karis French
Honors Projects
Microcrystalline tests are chemical tests that involve the mixing of a substance with a specific reagent resulting in the formation of a crystal structure. Currently, microcrystalline tests are used as presumptive tests in forensic drug chemistry laboratories to provide the suspected identity of unknown substances. There is, however, a limited amount of research on this use of microcrystalline structures. Additionally, this existing research is outdated and does not include some of the newer commonly encountered controlled substances including fentanyl, clonazepam, and diazepam. This literature-based review attempts to identify reagents that could be used in microcrystalline tests for the identification of …
Impacts Of Nutrient Addition And Disturbance On Coastal Dune Arthropod Communities And Trophic Interactions, Kayla Beitzel
Impacts Of Nutrient Addition And Disturbance On Coastal Dune Arthropod Communities And Trophic Interactions, Kayla Beitzel
Graduate Theses and Dissertations (2019 - present)
Coastal dune ecosystems face ongoing threats from human-mediated disturbance and altered resource availability. Because these dunes provide critical habitat for many organisms, including shorebirds, beach mice, and arthropods, changes in disturbance regimes or resource availability can impact plant communities and higher trophic levels by altering plant richness and productivity, which in turn influence arthropod abundance and diversity. To examine how disturbance and nutrient addition affect arthropod communities, we established twenty 5×5 m plots on Dauphin Island, crossing mechanical disturbance with a 10 g m⁻² addition of nitrogen, phosphorus, and potassium, replicated across five experimental blocks. Arthropods were sampled using three …
The Ecology Of Arthropod Rain In A Tropical Forest., Andrew Robert Seiler
The Ecology Of Arthropod Rain In A Tropical Forest., Andrew Robert Seiler
Electronic Theses and Dissertations
Tropical forests are structured by complex vertical linkages and nutrient exchanges between canopy and understory habitats. These linkages include the downward flux of organisms, the movement of canopy fauna, and the recycling of nutrients through litter and organic matter deposition. This dissertation investigates arthropod rain and its role in connecting the canopy and forest floor processes in a lowland tropical forest in Panama. Chapter 2 quantifies “arthropod rain”, the fall of canopy arthropods into the understory. Using pan and pole traps, I measured the composition, abundance, and biomass of arthropods falling from the canopy and assessed environmental drivers of the …
Effect Of Polymer Contaminants Sourced From Coated Paper On The Performance Of The Resulting Recycled Paper, Ezekiel J. Guevarra
Effect Of Polymer Contaminants Sourced From Coated Paper On The Performance Of The Resulting Recycled Paper, Ezekiel J. Guevarra
All Theses
The growing demand for sustainable packaging has accelerated the use of paper-based materials as alternatives to plastics. To provide barrier and functional properties, these materials are often modified with polymer coatings. While beneficial during use, such coatings can persist as contaminants during recycling, potentially disrupting fiber bonding and reducing the quality of recycled paper. This study examined the impact of extrusion-coated low-density polyethylene (LDPE) films and two aqueous dispersions (Vapor/Water-Barrier, Acrylic Film (VWAF) and Oil & Grease Barrier (OGBF)) on contaminant distribution and mechanical performance of recycled handsheets. Kraft paper coated at varying levels was repulped and formed into handsheets, …
Multiscale Modelling Of Eg5: Structural Insights Into Microtubule Interactions, Atp Hydrolysis, And Allosteric Inhibition Mechanisms, Soundarya Priya Alexandar Ms
Multiscale Modelling Of Eg5: Structural Insights Into Microtubule Interactions, Atp Hydrolysis, And Allosteric Inhibition Mechanisms, Soundarya Priya Alexandar Ms
Theses and Dissertations
The mitotic kinesin EG5 is essential for spindle bipolarity and accurate chromosome segregation during cell division, making it a validated anti-cancer target. Unlike conventional microtubule-targeting agents, EG5 inhibitors offer mitosis-specific action, reducing neurotoxicity. Although inhibitors targeting EG5’s allosteric site-I have been extensively studied, mechanistic insights into inhibition at site-II, and their combined effects, remain underexplored. This thesis systematically investigates the structural and dynamic mechanisms underlying EG5 function and its inhibition using an integrative computational approach.
Conformational analysis, coarse-grained dynamics, all-atom molecular dynamics simulations, and protein network analysis were performed on EG5 motor domain structures and EG5-microtubule complexes. Results show that …
Dosimetric Comparison Of Dynamic Conformal Arc Using Ezfluence Versus Dynamic Conformal Arc With A Posterior Static Field, A Retrospective Thoracic Spine Study, Michelle Klemm
Masters Projects
Purpose
Spinal metastases are a common complication of advanced cancer, often requiring palliative radiation therapy. This study compares two dynamic conformal arc (DCA) based techniques for thoracic spine metastases: a single arc plan generated using EZFluence and a hybrid technique combining DCA with a posterior-anterior (PA) static field. The goal was to evaluate dosimetric differences in target coverage and organ-at-risk (OAR) sparing.
Methods
Ten thoracic spine computed tomography (CT) datasets from The Cancer Imaging Archive were retrospectively planned with both techniques using Eclipse v16.0. Each plan prescribed 3000 cGy in 10 fractions to a planning target volume (PTV) encompassing T5–T9 …
Sustainability: Buzz Word Or Future Of Fashion? Measuring The Feasibility Of Outright Sustainability Among Fast Fashion’S Biggest Agents, Ryan Miller
Apparel Merchandising and Product Development Undergraduate Honors Theses
Abstract
The fashion industry is currently experiencing unsustainable rates of pollution within its supply chains. The rapid increase in demand for short lead times perpetrated by large-scale retailers has led to hazardous practices negatively affecting both the environmental conditions and working conditions of producing countries. With this increased pressure, relationships between brands and suppliers have become untenable. Limited transparency and imbalanced power dynamics at the hand of the industry’s leading retailers require restructuring in order to build more sustainable and equitable supply-chain practices. Further, governmental regulation is currently limited in its capacity to enforce sustainable business practices on a global …
Pediatric Occupational Therapists’ Perception On How Nature-Based Play Affects Fine Motor Development, Abbi M. Rosenow
Pediatric Occupational Therapists’ Perception On How Nature-Based Play Affects Fine Motor Development, Abbi M. Rosenow
Human Development and Family Sciences Undergraduate Honors Theses
This study aimed to explore the benefits of nature-based pediatric occupational therapy and the influence of nature and nature-based play on fine motor development. It was hypothesized that nature and nature-based play would positively impact a child’s fine motor skills, and that nature-based occupational therapy would offer unique benefits to a child’s therapeutic experience. To examine these relationships, a survey was distributed to pediatric occupational therapists across the United States. The survey was designed to gather insights into how occupational therapy supports fine motor development, how nature-based play/therapy enhances these skills, and the perceived benefits of incorporating nature into therapeutic …
Changes In Rfi Values Of Omomyid Mandibular Molars In Response To Climatic Shifts, Hannah Vanooteghem
Changes In Rfi Values Of Omomyid Mandibular Molars In Response To Climatic Shifts, Hannah Vanooteghem
Masters Theses
Molar anatomy reflects the functional demands of food mastication, and dental topography provides a quantitative method for evaluating how molar structure relates to dietary niche. Relief index (RFI), a dental topographic measure, has been successfully used to infer diet in extant and fossil mammals. This study tests two hypotheses regarding mandibular molars of early Eocene omomyids: (1) There is an association between changes in omomyid RFI values of first and second mandibular molars and changes in climatic variables (temperature and precipitation) from Wa0 to Wa5, and (2) The first and second mandibular molar RFI values of omomyid species are significantly …
Assessing The Viability Of A Proposed Third-Party Reusable Foodware System: An Environmental And Economic Comparison, Margaret Milani
Assessing The Viability Of A Proposed Third-Party Reusable Foodware System: An Environmental And Economic Comparison, Margaret Milani
All Theses
The United States generates 73 million tons of plastic waste annually, with over 6% attributed to the restaurant industry. The EPA recommends that restaurants reduce their plastic waste by transitioning to reusable foodware items. Previous studies have shown that using a single reusable foodware item, such as a cup, can result in lower environmental impacts and greater economic benefits compared to single-use plastic alternatives. However, the upfront costs of purchasing reusables, commercial dishwashers, and other associated expenses remain significant barriers for restaurants, leading many to continue using single-use plastic foodware. This study aims to analyze and compare the environmental impacts …
Biodegradable Active Packaging: Exploring The Antimicrobial Efficacy And Compostability Of Chitosan-Based Films, Rachel Mchugh
Biodegradable Active Packaging: Exploring The Antimicrobial Efficacy And Compostability Of Chitosan-Based Films, Rachel Mchugh
All Theses
The overarching purpose of this experiment is to create an active packaging component that has both antimicrobial and biodegradable properties specifically designed for poultry food products. For the scope of this study, the packaging component created would theoretically be used in conjunction with another material, such as a poultry tray which are commonly used for fresh poultry products. Based on the scope and purpose of this experiment, biopolymer films and coatings were considered after the initial literature review. Due to the goals of the packaging component, chitosan, a polysaccharide shown to have antimicrobial properties and an inherent ability to biodegrade, …
Fully Bio-Based, Flexible, Non-Isocyanate Polyurethane Foams With High Lignin Content For Protective Packaging Applications, Kathryn N. Evancho
Fully Bio-Based, Flexible, Non-Isocyanate Polyurethane Foams With High Lignin Content For Protective Packaging Applications, Kathryn N. Evancho
All Theses
Polyurethane foam is a valuable material with applications across the automotive, packaging, construction, appliance, and furniture industries. However, traditional polyurethane foams are made from petroleum-based precursors including harmful isocyanates. Isocyanates are the leading cause of workplace asthma and are made from toxic phosgene gas, representing a challenge to green chemistry principles such reducing risk and environmental footprint. To address these concerns, non-isocyanate polyurethane (NIPU) foams have been the focus of research for the past decade, but they still face significant challenges in achieving commercial viability. NIPUs replace the traditional polyurethane reaction with a safer, non-isocyanate process most often employing cyclic …
Functional Analysis Of Chromatin Remodeler Csb In Parp1/2- Mediated Oxidative Dna Lesion Repair, Rabeya Bilkis
Functional Analysis Of Chromatin Remodeler Csb In Parp1/2- Mediated Oxidative Dna Lesion Repair, Rabeya Bilkis
Biomedical Sciences ETDs
The ATP-dependent chromatin remodeler Cockayne syndrome protein B (CSB) is essential for maintaining genome integrity. Mutations in CSB are the primary cause of Cockayne syndrome (CS), a premature aging disorder with severe sun sensitivity and neurodevelopmental symptoms. However, the precise mechanisms underlying the disease etiology remain poorly understood. Given the critical roles of oxidative stress in aging and neurodegenerative disorders, this research sought to determine the mechanisms of CSB’s functions in oxidative DNA damage repair.
In the first aim, we investigated how CSB participates in PARP1/2-mediated oxidative DNA repair. We showed that PARP1 and PARP2 recruit CSB to oxidized chromatin …