Molecular, Genetic, and Biochemical Nutrition Commons^™

Molecular Mechanisms Of Exercise-Stimulated Resolution Of Inflammation And Its Dietary Dependence., Ernesto H. Pena Calderin

Electronic Theses and Dissertations

Diet-induced obesity and adipose tissue (AT) inflammation that ensues sets the stage for systemic metabolic inflammation, disrupted insulin signaling, and eventual type 2 diabetes (T2D) development. At the center of this pathology lies a disruption in endogenous inflammation resolution pathways characterized by an imbalance in lipid mediator production (greater abundance of pro-inflammatory to pro-resolving lipids). Additionally, obese states are characterized by adrenergic deficiency, especially in response to physical activity. Inflammatory processes have been experimentally mitigated by either the pharmacological inhibition of pro-inflammatory signals (i.e., Leukotriene B₄ (LTB₄) and its receptor BLT1, which establishes a potent chemotactic stimulus …

Editorial: Inter-Organ Crosstalk During Exercise In Health And Disease: Extracellular Vesicles As New Kids On The Block, Kenneth Verboven, Ivan Jose Vechetti Jr

Department of Nutrition and Health Sciences: Faculty Publications

Within exercise physiology, the study of factors potentially mediating interorgan crosstalk during and after exercise is a fascinating field of research. As exercise activates a plethora of metabolic pathways in several tissues, organs and systems, examining the underlying biological mechanisms contributing to exercise related metabolic benefits is imperative. Since two decades, the skeletal muscle is known to secrete humoral factors into the circulation in response to exercise, originally described as “myokines” by Pedersen et al. (2003). These myokines are now well known and extensively studied in the field of exercise science (Pedersen and Febbraio, 2012). Interestingly, exercise also triggers other …

Vulnerable And Resilient Phenotypes In A Mouse Model Of Anorexia Nervosa, Jeff A. Beeler, Devry Mourra, Roseanna M. Zanca, Abigail Kalmbach, Celia Gellman, Benjamin Y. Klein, Rebecca Ravenelle, Peter Serrano, Holly Moore, Stephen Rayport, Susana Mingote, Nesha Burghard

Advanced Science Research Center

Background

Increased physical activity is a common feature of anorexia nervosa (AN). Although high activity levels are associated with greater risk of developing AN, particularly when combined with dieting, most individuals who diet and exercise maintain a healthy body weight. It is unclear why some individuals develop AN while most do not. A rodent model of resilience and vulnerability to AN would be valuable to research. Dopamine, which is believed to play a crucial role in AN, regulates both reward and activity and may modulate vulnerability.

Methods

Adolescent and young adult female C57BL/6N mice were tested in the activity-based anorexia …

Sex-Specific Relationships Among Iron Status Biomarkers, Athletic Performance, Maturity, And Dietary Intakes In Pre-Adolescent And Adolescent Athletes, Marni E. Shoemaker, Zachary M. Gillen, Brianna D. Mckay, Nicholas A. Bohannon, Sydney M. Gibson, Karsten Koehler, Joel T. Cramer

Department of Nutrition and Health Sciences: Faculty Publications

Background: The purpose of this study was to examine relationships among biomarkers of iron status, athletic performance, growth and development, and dietary intakes in pre-adolescent and adolescent male and female athletes.

Methods: Two-hundred and forty-nine male (n = 179) (mean ± standard deviation for age = 12.0 ± 2.1 years, height = 156.3 ± 13.9 cm, and weight = 49.1 ± 16.5 kg) and female (n = 70) (12.0 ± 2.2 years, 152.4 ± 12.3 cm, 45.3 ± 14.5 kg) athletes volunteered for capillary blood sample, anthropometric, athletic performance, and dietary intake assessments. Outcomes included maturity offset from peak height …

A Low-Carbohydrate Ketogenic Diet Combined With Six Weeks Of Crossfit Training Improves Body Composition And Performance, Rachel M. Gregory

Masters Theses, 2010-2019

A low-carbohydrate ketogenic diet (LCKD) is a popular approach to weight and fat loss. CrossFit is a high-intensity power training (HIPT) type exercise for all levels of age and fitness that has gained recognition as one of the fasting growing sports in America. No previous research has been found which examines body composition changes or performance in individuals consuming a LCKD and participating in CrossFit training. PURPOSE: The purpose of this research was to examine the effects of a 6-week LCKD and CrossFit program on body composition and performance. METHODS: Twenty-seven non-elite CrossFit subjects (mean ± SD age = …

Low Energy Availability In Exercising Men Is Associated With Reduced Leptin And Insulin But Not With Changes In Other Metabolic Hormones, Karsten Koehler, Neele R. Hoerner, Jenna C. Gibbs, Christoph Zinner, Hans Braun, Mary Jane De Souza, Wilhelm Schaenzer

Department of Nutrition and Health Sciences: Faculty Publications

Low energy availability, defined as low caloric intake relative to exercise energy expenditure, has been linked to endocrine alterations frequently observed in chronically energy-deficient exercising women. Our goal was to determine the endocrine effects of low energy availability in exercising men. Six exercising men (V_O2peak : 49.3 ± 2.4 ml · kg⁻¹ · min⁻¹) underwent two conditions of low energy availability (15 kcal · kg⁻¹ fat-free mass [FFM] · day⁻¹) and two energy-balanced conditions (40 kcal · kg⁻¹ FFM · day⁻¹) in randomized order. During one low energy availability and …

The Role Of Exercise In Polychlorinated Biphenyl Induced Cardiovascular Disease, Margaret O'Bryan Murphy

Theses and Dissertations--Nutritional Sciences

Cardiovascular disease remains the leading cause of death in Western societies. Endothelial dysfunction is one of the initiating steps in the development of atherosclerosis. While there is a strong correlation with a person’s genetics, lifestyle factors including smoking, physical activity, and diet can significantly increase a person’s susceptibility to the development of atherosclerosis. In addition to these lifestyle factors, there is a strong body of evidence linking exposure to environmental pollutants including persistent organic pollutants such as polychlorinated biphenyls to increased cardiovascular disease and mortality. It has been well-established that exercise protects against cardiovascular disease, but whether exercise can modulate …