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Molecular, Genetic, and Biochemical Nutrition Commons™
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- Adipocytes (1)
- Adrenal gland (1)
- Aryl hydrocarbon receptor (1)
- Cardiovascular disease (1)
- Coregulators (1)
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- Diabetes (1)
- Diet (1)
- Endothelial function (1)
- Exercise (1)
- FOXS1 (1)
- Kinase signaling (1)
- MASLD (1)
- Nuclear receptor (1)
- Oxidative stress (1)
- Polychlorinated biphenyl (1)
- Polychlorinated biphenyls (1)
- Progenitor thymic homing (1)
- Resveratrol (1)
- Scavenger receptor class B type I (1)
- T cell development (1)
- Thymic recovery (1)
Articles 1 - 4 of 4
Full-Text Articles in Molecular, Genetic, and Biochemical Nutrition
Nutrient-Driven Transcription Factor-Dna Interactions And Their Signaling Mechanisms In Metabolic Disease, Evelyn A. Bates
Nutrient-Driven Transcription Factor-Dna Interactions And Their Signaling Mechanisms In Metabolic Disease, Evelyn A. Bates
Theses and Dissertations--Nutritional Sciences
Metabolic homeostasis is maintained through tightly coordinated signaling networks that integrate diverse physiological inputs. Central to this regulation are transcription factors, which sense nutrient, hormonal, and vitamin-derived signals and translate them into coordinated gene expression programs. Transcription factor activity is governed by DNA binding, recruitment of coregulatory proteins, and interactions with specific response elements in gene promoters, which allows them to selectively modulate diverse metabolic pathways. Owing to their multifactorial and tunable nature, transcription factors have emerged as promising targets for the treatment and diagnosis of metabolic diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). This dissertation explores the molecular …
Role Of Scavenger Receptor Class B Type I In Thymopoiesis, Zhong Zheng
Role Of Scavenger Receptor Class B Type I In Thymopoiesis, Zhong Zheng
Theses and Dissertations--Nutritional Sciences
T cells, which constitute an essential arm in the adaptive immunity, complete their development in the thymus through a process called thymopoiesis. However, thymic involution can be induced by a couple of factors, which impairs T cell functions and is slow to recover. Therefore, understanding how thymopoiesis is regulated may lead effort to accelerate thymic recovery and improve immune functions in thymocyte-depleted patients. In this project, we identified scavenger receptor BI (SR-BI), a high density lipoprotein (HDL) receptor, as a novel modulator in thymopoiesis. In mice, absence of SR-BI causes a significant reduction in thymus size after puberty and a …
The Role Of Exercise In Polychlorinated Biphenyl Induced Cardiovascular Disease, Margaret O'Bryan Murphy
The Role Of Exercise In Polychlorinated Biphenyl Induced Cardiovascular Disease, Margaret O'Bryan Murphy
Theses and Dissertations--Nutritional Sciences
Cardiovascular disease remains the leading cause of death in Western societies. Endothelial dysfunction is one of the initiating steps in the development of atherosclerosis. While there is a strong correlation with a person’s genetics, lifestyle factors including smoking, physical activity, and diet can significantly increase a person’s susceptibility to the development of atherosclerosis. In addition to these lifestyle factors, there is a strong body of evidence linking exposure to environmental pollutants including persistent organic pollutants such as polychlorinated biphenyls to increased cardiovascular disease and mortality. It has been well-established that exercise protects against cardiovascular disease, but whether exercise can modulate …
Polychlorinated Biphenyl Ligands Of The Aryl Hydrocarbon Receptor Promote Adipocyte-Mediated Diabetes, Nicki A. Baker
Polychlorinated Biphenyl Ligands Of The Aryl Hydrocarbon Receptor Promote Adipocyte-Mediated Diabetes, Nicki A. Baker
Theses and Dissertations--Nutritional Sciences
Numerous epidemiology studies suggest a correlation between exposures to polychlorinated biphenyls (PCBs) and the development and severity of type 2 diabetes (T2D); however, mechanisms remain largely unknown. Previous studies demonstrated that PCBs that are ligands of the aryl hydrocarbon receptor (AhR) promote the expression of proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), that are linked to insulin resistance in adipocytes. To explore potential mechanisms linking PCB exposures to diabetes, we developed a mouse model of glucose and insulin intolerance induced by acute and chronic exposures to PCB-77. We hypothesized that PCB ligands of AhR result in adipocyte-specific elevations in TNF-α …