Molecular, Genetic, and Biochemical Nutrition Commons^™

Essential Amino Acid (Eaa) Regulation Of Skeletal Muscle Protein Turnover With Age, Mary Komp

Graduate Theses and Dissertations

Skeletal muscle (SM) is vital for both long term health and quality of life. Recent research suggests an increase in catabolic signals with age triggers pathologic conditions, such as sarcopenia. Although results from in vitro studies model how EAA can regulate muscle protein synthesis (MPS), the relevance of these models to muscle protein breakdown (MPB) and the presence of physiological EAA concentrations remains to be established. Therefore, the objective of this study was to determine the effects of a low, normal, and supra physiological dose of EAA (0.2, 1.0, and 3.0 x EAA) in a young (passages 2-10) and aging …

Efficacy Of Multivitamin-Mineral Supplementation On Measures Of Anxiety, Depression, Self-Esteem, Dysregulation, And Perceived Stress In Young Adults, Courtney Gorden

Graduate Theses and Dissertations

Mental health in the United States is at an all-time low with 21% of adults 18+ suffering from depression or anxiety. When compared with other categories, emerging adults (18-25 years old) have the highest prevalence of mental health disorders at 30%. Young adults face an inordinate amount of stress given the COVID-19 pandemic, being in a unique developmental stage, experiencing new relationships, and transitioning from high school to their professional lives. Vitamins and minerals have roles in neurobiochemistry and have been investigated for effects on mental health with mixed results. Few studies factor in the unique emerging adult developmental stage …

Exercise Is Medicine: Health And Fitness At The U Of A And Beyond, Erin Howie Hickey

Seminars

Dr. Howie Hickey will discuss the latest research on the benefits of physical activity for physical and mental health, from COVID-19 to depression, including what the science can say about the optimal dose and intensity. She will share recent data collected by the Exercise is Medicine team on physical activity, fitness and wellness in the University of Arkansas community and discuss future directions and opportunities.

The Importance Of Exercise And Nutrition In Early Life, Elisabet Borsheim

Seminars

Dr. Børsheim will present her research on the important of exercise and nutrition in early life. In her presentation Dr. Børsheim will focus on childhood obesity and show that this can increase risk for later life metabolic dysfunction. She will discuss if physical fitness can attenuate negative effects of obesity in children and if there are critical windows of development where physical activity is of specific importance. Finally, she will present data on impact on early physical activity and nutrition on response to exercise later in life.

Anti-Inflammatory Properties Of Blackberry Phenolic And Volatile Compounds, Pauline Morin

Graduate Theses and Dissertations

Berries are known for many health benefits including anti-inflammatory properties that lower risks of chronic diseases. These properties have been linked to high concentrations of phenolic compounds, especially anthocyanins. However, the present study hypothesized that volatiles could contribute to the berries’ bioactive properties. Thus, the objectives of this research are to profile the phenolic and volatile composition of 16 blackberry genotypes harvested at the Fruit Research Center of the University of Arkansas and to evaluate the antiinflammatory capacities of three selected genotypes on inflamed cells. Phenolic and volatile profiles were evaluated using chromatographic techniques. The three genotypes A2528T, A2587T and …

The Effect Of Epa And Dha On Skeletal Muscle Physiology And Energy Balance, Saeed Jebor Ghnaimawi

Graduate Theses and Dissertations

Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) supplementation commonly suggested during pregnancy confers many health benefits on offspring and more recently improves fetal BAT development and induces myoblast trans-differentiation into adiopocytes through activating PPARs expression. Embryonic myoblast is a highly flexible cell showing great capacity to change its phenotype into adipocyte in response to EPA and DHA supplementation in many in vitro models. However, a little is known about the identity of derived adipocytes, whether, they change into brown or white adipocyte, and in vivo evidence is still missing. Given that the myogeneis process is initiated at the mid of …

Antioxidant Properties And Anti-Cancer Effects Of Polyphenols In Sweetpotato Leaves, Josue Bolanos

Graduate Theses and Dissertations

Although the root is widely consumed, sweetpotato leaves (SPL) are often discarded and are only consumed in a few countries. In the United States, SPL consumption is limited to private gardens, particularly in the Southeastern United States. Not only are SPL a good source of nutrients such as vitamins and minerals, but they also contain polyphenol compounds including the caffeoylquinic acid derivatives and carotenoids such as lutein. Several studies have shown the polyphenol contents and antioxidant capacities of SPL, which vary based on year and variety, while few studies have shown anti-colon cancer effects of SPL. Therefore, this study investigated …

Effects Of Broccoli And Carrots On Fecal Microrna Expression In Infants: A Short-Term Feeding Study, Kaleigh E. Beane

Graduate Theses and Dissertations

Diets, through multiple mechanisms, cause significant impact on human health and disease etiology; proposed modes of action include modulation of non-coding RNAs and influences on the gut microbiome. Specifically, phytochemicals change human miRNA expression thereby impacting gut microbiome and/or increasing host immune functions. Apiaceous and cruciferous vegetables have been linked to decreased chronic inflammation, which is closely related with the host immune system, yet it is not investigated how these two classes of vegetables influence the colonic miRNA profile. In this study, therefore we aimed to determine the effects of short-term feeding of broccoli and carrot to infants on fecal …

Nutritional Supplementation And Skeletal Muscle Health In Chronic Diseases, Hexirui Wu

Graduate Theses and Dissertations

Prevalence of chronic diseases in the United States keeps increasing in recent years. There are approximately four in ten adults having chronic diseases in America. Chronic diseases include obesity, aging, heart diseases, cancer and many others. This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body composition. Therefore, the first objective of the thesis is to determine gene expression of selected pathways in …

Development Of Arkansas Net Energy Equation, Katie Hilton

Graduate Theses and Dissertations

The modern broiler is growing at a rapid rate generating tremendous amounts of heat. A sensitive Net Energy (NE) system is needed to measure body heat production (HP) generated primarily by daily maintenance and synthesis and degradation of myofibrillar and sarcoplasmic protein. The first two chapters present evaluation of the classic way to calculate NE versus a new methodology; the Arkansas NE (Ark NE) system, with birds from two genetic lines fed diets with different AA content or different ME content in two different environmental temperatures.

Utilizing together the Net Energy maintenance (NEm), determined from indirect calorimetry, and Net Energy …

Liver Transcriptomic Analysis After Short- And Long-Term Feeding Of Soy Protein Isolate And Its Ability To Reduce Liver Steatosis In Obese Zucker Rats, Melisa Kozaczek

Graduate Theses and Dissertations

According to the Centers for Disease Control and Prevention (CDC) the prevalence of obesity in adults in the United States during 2017-2018 was a 42.4%, a high number considering all the risks factors associated with this disorder, such as cardiovascular disease, insulin resistance, diabetes type 2, and fatty liver disease, among others. Fatty liver disease is the accumulation of lipids in the liver that can account for more than 5 to 10% of the liver’s weight. There are two types of fatty liver disease, alcoholic fatty liver disease (AFLD), and non-alcoholic fatty liver disease (NAFLD). AFLD is the detrimental accumulation …

Effects Of Mitochondrial Nadp+-Dependent Isocitrate Dehydrogenase Deficiency On Fructose-Induced Obesity In Mice, Allison Michelle Montalbano, Kaleigh Elizabeth Beane

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia. Among many contributing factors to obesity, fructose may be one of the major reasons as it disrupts the antioxidant system thereby resulting in an accumulation of reactive oxidative species and leading to obese conditions. The enzyme, isocitrate dehydrogenase 2 (IDH2), reduces nicotinamide adenine dinucleotide phosphate from the TCA Cycle, hence might be implicated with not only energy metabolism but also cellular redox homeostasis. Therefore, the hypothesis was that IDH2 deficiency in mice would exacerbate hepatic lipid …

Antiproliferative Activity Of Carotenoids, Phenolic Compounds, And Volatile Terpenoids In Carrots (Daucus Carota L.), Brittany Frederick

Graduate Theses and Dissertations

Epidemiological studies have shown an association between high carrot consumption and low prevalence of cancer. This observation has been thought to be attributed to carrot carotenoids. Despite this, various intervention trials have displayed no changes in incidence or increased incidence of cancer with carotenoid supplementation. It is possible that carrot phenolics are responsible for this association, though this has not been widely accepted. Volatile terpenoids from carrots have not been studied in this regard. Therefore, the primary objective of this study was to compare the antiproliferative effects of carotenoids, phenolics, and volatile terpenoids extracted from carrots on Caco-2 colon cancer …

Effect Of Endophyte-Infected Tall Fescue Toxins On Growth Performance And The Microbial Community In The Rumen And Feces In Pregnant Ewes, Saleh Alrashedi

Graduate Theses and Dissertations

Fifty pregnant Katahdin ewes grazed pastures with high (HE) and moderate (MI) levels of Neotyphodium coenophialum-infected tall fescue between February 1 and May 24 to determine the impacts of tall fescue toxins on body weight (BW), body condition scores, FAMACHA scores, fecal egg counts (FEC), and serum Cu, Zn, prolactin, and non-esterified fatty acids (NEFA). Within those 50 ewes, 15 were selected randomly for fecal and rumen sampling to assess the impacts of HE and MI on the microbiome community. Total bacterial DNA was extracted from rumen and fecal samples, and alpha and beta diversities were used to relate microbiome …

The Effect Of Omega-3 Fatty Acids On Energy Metabolism, Energy Intake, And Metabolic Response In Normal Weight And Overweight And Obese School Aged Children (8-12 Years), Charlayne Mitchell

Graduate Theses and Dissertations

Background: Obesity is a major health concern in the United States. Omega-3 fatty acids (O3FA) have been observed to improve metabolic health and therefore might be useful in treatment of obesity. However, little is known regarding the effect of O3FA on school aged normal weight and overweight children.

Objective: The objective of this thesis was to determine if habitual intake of O3FA at breakfast improves energy metabolism, appetite, and metabolic response in overweight and obese school-aged children.

Design: Twenty healthy, normal weight (NW; n = 11) and overweight (OW; n = 9) children aged 8-12 years were randomly assigned to …

The Effect Of Protein Quantity And Quality At Breakfast On Energy Metabolism, Appetite And Metabolic Health, Brianna Lynne Neumann

Graduate Theses and Dissertations

Obesity is a global health concern and, within the United States, the current obesity rate is 36% and projected to double within the next two decades. Obesity is linked to many chronic diseases such as cancer, heart disease and type 2 diabetes. In young females, weight gain (5-11 kg) between the ages of 20-30 years increases the risk of developing type 2 diabetes and cardiovascular disorders later in life. The cause of obesity is multifactorial in nature, however fundamentally weight gain occurs when energy intake is greater than energy expended (i.e. calories in > calories out). Therefore, identifying and validating nutritional …

Evaluation Of Phytate And Phytase Interactions And Phytase Phase-Feeding On Bird Performance, Bone Characteristics And Meat Quality In Young Growing Broilers, Chance L. Williams

Graduate Theses and Dissertations

Two trials were performed using one-day-old male Cobb x Cobb 500 broilers to determine how dietary phytate and phytase levels as well as phytase phase feeding impacted bird performance parameters, tibia characteristics, and malonaldehyde (MDA) content of the liver, breast and thigh tissues. The first experiment consisted of 1,008 birds randomly placed in 48 floor pens within two commercial broiler houses at the Applied Broiler Research Farm (ABRF; 21 birds per pen; 0.76 ft2 per bird). A 2 X 3 factorial design was used with two levels of dietary phytate (0.21 and 0.31 %) and three levels of phytase supplementation …

Effects Of Grain Sorghum Muffin On Blood Glucose And Insulin Responses In Prediabetic Men, Xuan Gu

Graduate Theses and Dissertations

Prediabetes is a sub-health condition in the development to type 2 diabetes, which has been long overlooked. Grain sorghum contains functional starch fractions, which have been widely reported for their potential on blood glucose control and diabetes prevention. A human study with prediabetic men was conducted to investigate the effects of sorghum starch on postprandial blood glucose and insulin levels. Grain sorghum and wheat (control) muffins containing 50 g total starch were consumed by 15 prediabetic male subjects on two mornings with a 1-week washout period. Plasma samples were collected on -15 (baseline), 0, 15, 30, 45, 60, 75, 90, …

Evaluation Of Betaine And Methionine Replacement For Improving Performance And Meat Quality For Broilers Reared Under Higher Temperature Conditions, Malea Graham Frank

Graduate Theses and Dissertations

4,096 broiler chicks were randomly allocated to 128 floor pens (32 birds/pen). 2,048 day-old male broilers were placed in the east end of a barn, and the following week 2,048 day-old male broilers were placed in the west end. At each placement day, half of the chicks were Cobb 500 and half were Ross 708, and each pen contained only one breed source. East end birds received coccidiostat in the feed, west end received coccidial vaccine, and each end was under separate environmental control. Eight diets contained two levels of coccidiostat (0, 1 lb./ton), methionine (deficient, adequate), and betaine (0, …

Effect Of Functional Starch In Brown Rice And Grain Sorghum On Plasma Glucose And Insulin Responses In Humans, Nicole Marie Poquette

Graduate Theses and Dissertations

Diabetes and obesity are chronic illnesses increasing at dramatic rates in the U.S. and around the world. Research has looked to prevent or control diabetes and obesity through functional ingredients such as healthy-dietary carbohydrates to control blood glucose levels. Starch is a principle carbohydrate, which influences blood glucose levels, and measuring starch digestibility fractions can help predict the glucose response in the body. The objectives of this study were to investigate the functional starch content of parboiled brown rice flour and grain sorghum flour, and measure the effects on postprandial plasma glucose and insulin levels of 14 and 10 healthy …

In Vitro Analysis Of Short Chain Fatty Acids And Human Fecal Microbiota Stimulated By Pectin Sources, Byungjick Min

Graduate Theses and Dissertations

As interest increases for colonic health, various studies have been conducted to investigate functional ingredients for host health and prevention of chronic disease in humans such as colon cancer and Type 2 diabetes. In particular dietary fiber has been reported to have beneficial effects on colonic health. More recently, dietary fiber has been categorized based on its characteristics and numerous studies have been conducted to determine correlations with chronic diseases. Pectin is a naturally occurring biopolymer that has been used in various applications for purposes of pharmaceutical and biotechnology. Pectin is a soluble dietary fiber and can be entirely fermented …

Physio-Chemical And Sensory Properties Of A Nutrient-Fortified Extruded Product, Tajudini Lassissi Akande

Graduate Theses and Dissertations

Protein malnutrition is responsible for half the deaths of children under the age of five each year in developing countries. More than 4%, 26%, and 70% of children with protein malnutrition live in Latin America/the Caribbean, Africa, and Asia, respectively. The objective of this research was to develop a novel snack made with millet, black eye bean (from Niger Republic), and rice flour fortified with soybean meal protein using extrusion technology. Proximate analysis of the four flours was carried out to determine their chemical composition. Central composite design (CCD) was used to obtain best extrusion conditions to develop a protein-enriched …

Nutrition Knowledge Of Pre-Medical Students, Jennifer Newcome, Cynthia Moore

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Nutrition knowledge has been shown to be increasingly critical in physician practice. Therefore, education has also become very critical. Medical schools have been working over the last few decades to include nutrition education in their curriculum, but due to many barriers, it is difficult to fulfil requirements. It is the purpose of this descriptive study to determine the nutrition knowledge of pre-medical students at the University of Arkansas and conclude if a nutrition class for these students would be beneficial. The average score of the nutrition knowledge assessment was 11.2 ± 3.04 out of a possible 23. Because the literature …

Subcritical Water Hydrolysis Of Whey Proteins, Ashley Dawn Espinoza

Graduate Theses and Dissertations

Hydrolyzing food by-products is a unique approach to potentially increase by-product value and reduce waste. An abundant by-product of cheese production, whey, contains all essential amino acids and some distinctive peptides with functional and nutraceutical properties. Typically, proteins from whey are tailored for specific uses by chemical or enzymatic hydrolysis; however, subcritical water hydrolysis is a novel alternative used successfully to hydrolyze various substrates. Nevertheless, minimal research exists on: (1) the hydrolysis of whey protein; (2) the incorporation of additives; (3) the hydrolysis of whole whey; and (4) the production of volatiles when using subcritical water hydrolysis.

Therefore, whey protein …

Effectiveness Of Weight Control Through Weight Watch Programs, V. A. Black, P. Boumtje

Journal of the Arkansas Academy of Science

Linear probability estimation and survey data are employed to quantify the influence of the lifestyles of individuals on the change in their body mass index (BMI). The analysis also explores the effects of demographic characteristics (age, gender, and ethnicity) in weight management. Results suggest evidence of association between changes in lifestyle and changes in the BMI of individuals.