Human and Clinical Nutrition Commons^™

The Short- And Long-Term Effects On The Microbiome Of Infants Who Are Exposed To Opioids In Utero, Dawson Brown-Ezell

Undergraduate Honors Theses

Introduction: The gut microbiome is believed to have a significant impact on health throughout the lifespan, and the influence of infant nutrition and other environmental factors are of particular interest in its development. The aim of this research project was to learn more about the microbiome and short chain fatty acid (SCFA) composition of toddlers of differing weights, considering birth history, environment, and diet. In East Tennessee, opioid misuse is a growing issue, and a number of participants in this study were exposed in utero. We also hoped to identify related effects on infant’s SCFA composition. Finally, it is known …

Nutrition Education And The Effects On Athletic Performance In Collegiate Athletes With Low Energy Availability, Karleigh Sudenga

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Current research suggests that collegiate athletes lack nutritional knowledge needed for optimal athletic performance. The absence of basic nutritional knowledge in college athletes puts them at an increased risk for RED-S and its sports performance consequences. The objective of this narrative review is to evaluate the literature on low energy availability in collegiate athletes and determine if nutrition education can improve athletic performance. Multiple studies concluded that nutrition education may improve dietary intake in collegiate athletes, while there was one contradicting study that found that athletes improved nutritional knowledge but did not improve dietary intake. 3 studies found that low …

Narrative Review Of The Relationship Between Depression And Low Blood Folate And Vitamin B12 Levels, Jennifer Sip

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Depression is a common psychological mood disorder that impacts more than 16 million adults in the United States. It can impact several areas of a person’s life including physical activity, diet and daily activities. The role of nutrition in depression therapy has been researched for several years, with folate and vitamin B12 being the main highlights. Folate and vitamin B12 play a vital role in the development of the central nervous system and conversion of homocysteine to methionine. Past research has found inconsistent findings regarding the relationship between folate, vitamin B12 and their role in depression. This article dives into …

Association Of Diet Qualitymeasured By Three A Priori-Defined Dietary Patterns With Gut Microbiota And Intestinal Permeability Among Obese Individuals, Sarah Eaton, Heather Rasmussen, Weiwen Chai

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: The human gastrointestinal tract (GI)may play a critical role in the prevention of obesity and metabolic diseases. Considering the importance of a healthy diet for optimal health, this study examined associations of diet quality assessed by three a priori-defined dietary patterns (Healthy Eating Index 2010 [HEI-2010],Mediterranean Eating Pattern for Americans [MEPA], and Dietary Approaches to Stop Hypertension [DASH] with gut microbiota, short-chain fatty acids (SCFA) and intestinal permeabilitymarkers in adult obese participants.

Conclusions: Blautia abundance and inversely associated with intestinal permeability markers such as urinary 24-h sucralose levels suggesting diet quality may have positive impact on the human GI …

Intracellular Fate Of Bovine Milk Exosomes In Murine Bone Marrow-Derived Macrophages, Afsana Khanam, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Milk exosomes (MEs) and their microRNA cargos constitute novel bioactive food compounds, and bovine MEs (BMEs) are being considered for use in drug delivery. The internalization of MEs by macrophages and degradation in lysosomes (in all cells) limit biological activities. Here, we determined whether BMEs internalized by murine bone marrow-derived macrophages (BMDMs) retrofuse with the intralumenal membrane in the multivesicular body (MVB) for subsequent release into the extracellular space or whether BMEs are destined for degradation in lysosomes.

Conclusions: The retrofusion of BME-derived intralumenal MVBs and secretion of BME into the extracellular space is quantitatively minor in BMDMs. The majority …

Genetically Altered Bovine Milk Exosomes (Bmes) Evade Elimination Bymurine Bone Marrow-Derived Macrophages (Bmdms), Alice Ngu, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: To develop BMEs that evade elimination by BMDMs.

Conclusions: The elimination of BMEs UNL1 and UNL2 is significantly reduced compared unmodified BMEs in BMDM cultures. This is of great importance when using BMEs for delivering therapeutics.

Γ-Glutamyl Valine, Found In Dry Edible Beans, Is Anti-Diabetic In Db/Db Mice, Bikram Upadhyaya, Kaustav Majumder, Regis Moreau

Department of Nutrition and Health Sciences: Faculty Publications

Objectives: Dietary γ -glutamyl peptides (γ -GPs) found in dry edible beans exhibit biological activities (antioxidant, anti-inflammatory) with potential benefits against chronic metabolic disorders. γ -GPs are responsible for the desirable Kokumi flavor through allosteric activation of the Calcium Sensing Receptor (CaSR) present in multiple mammalian tissues. In this study, we investigated the metabolic effects of γ -glutamyl valine (γ -EV) in diabetic obese mice.

Conclusions: γ -EV improved the diabetic condition of db/db mice via modulation of glucose and lipid metabolism.

The Impact Of Covid-19 On Perceived Barriers And Facilitators To The Healthfulness Of Communities With Low-Income, Elder Varela, Jamie Zeldman, Alison Kuch, Yanli Wang, Mohammad Shushari, Elizabeth L. Hall, Jade Mcnamara, Jesse Stabile Morrell, Terezie Tolar-Peterson, Onikia Brown, Melissa D. Olfert, Lisa Franzen-Castle, Tandalayo Kidd, Sarah Colby, Geoffrey Greene, Karla P. Shelnutt

Department of Nutrition and Health Sciences: Faculty Publications

Background: The COVID-19 pandemic brought new challenges affecting the wellbeing of individuals in communities with low income. Understanding where people live and how those environments can facilitate or hinder living a healthy lifestyle is essential for developing interventions that target behavior change and health promotion. Objective: This study compares Extension Nutrition Educators’ (NEs) perceptions of the barriers and facilitators impacting the healthfulness of the environment of communities with low income in eleven states before and during the COVID-19 pandemic.

Associations Between Atherogenic Markers And Hearing Loss: National Health And Nutrition Examination Survey: 2011-2012, 2015-2016, Anna Anya Rombakh

All Master's Theses

Importance Hearing loss (HL) is a major public health problem that has been previously found to be associated with abnormal atherogenic markers.

Objective To investigate the associations between such atherogenic markers and the degree of HL using continuous NHANES data from cycle years 2011-2012 and 2015-2016.

Design, Study, and Participants This observational study used data from two National Health and Nutrition Examination Survey (NHANES) cycle years 2011-2012 and 2015-2016. NHANES continuously conducts data collection via home interviews and physical exams completed in their Mobile Examination Centers. NHANES participants ages 20-69 who partook in audiometry, anthropometric and laboratory testing were included. …

Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.

Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.

Methods. A sequential explanatory mixed-methods design was used for aims 1 …

Implementation Of An Inpatient To Outpatient Communication Pathway To Improve Outcomes In High-Risk Oncology Patients., Kimberly Procaccino Mba, Rd, Ldn, Janine Gilboy Rd, Ldn, Jennifer Brennan Rd, Cso, Erin Levine Rd, Cso, Ldn, Amanda Stone, Alyse Wittman

Clinical Nutrition Service

No abstract provided.

Comparing Retrospective Psu Measurements With The Leep-Covid 2020 Study To Ascertain Similarities In Calories Per Kilogram Of Body Weight For Ventilator-Dependent Covid-19 Patients, Kimberly Cephas

Clinical Nutrition Service

No abstract provided.

Navigating The Perfect Storm: Staffing Crisis During The Pandemic, Melissa Faura Rd, Ldn, Ann Flickinger Ms, Rd, Ldn, Kimberly Procaccino Mba, Rd, Ldn

Clinical Nutrition Service

No abstract provided.

The Role Of Ovarian Hormones In Appetite-Regulation: Examining The Post-Exercise Appetite Response In Pre- Vs Post-Menopausal Females, Jessica A.L. Tucker

Theses and Dissertations (Comprehensive)

INTRODUCTION: Appetite fluctuates across the menstrual cycle, suggesting ovarian hormones are involved in the regulation of appetite hormones and energy intake. Exercise is another regulator of appetite with higher intensity exercise generating a greater and more consistent suppression. Considering there is limited evidence investigating the role of ovarian hormones in appetite regulation, menopause represents a stage of life where ovarian function declines, thus providing an opportunity to further explore the role of ovarian hormones in the appetite-regulatory response to exercise. PURPOSE: To examine the role of ovarian hormones on appetite-regulating hormones in pre- and post-menopausal females following a …