Nutrition Commons^™

Mcdonald’S Users’ Perceptions Of Health And Nutrition, Quality, And Value On Visit Frequency, Claire Adams

Electronic Theses and Dissertations

With the vast amount of quick service restaurants (QSRs) that are available to consumers in the United States (U.S.), the hospitality industry has become an integral part of Americans’ diet and lifestyle. This study examines how McDonald’s customers’ perceptions of health and nutrition, quality, and value vary demographically (gender, age, ethnicity, educational level, and body mass index [BMI]) by McDonald’s visit frequency. An online survey was employed to collect data of participants who were 18 years of age and older, McDonald’s customers, and a resident of the U.S. Of the 843 respondents who filled out the survey, 607 (72%) surveys …

Evaluation Of Parent Involvement In Families In Transformation (Fit) Wellness Program For Children, Heather Walker

Electronic Theses and Dissertations

No abstract provided.

Risk Factors For The Female Athlete Triad In College Age Athletes Compared To Non-Athletes, Micaela Shirley Miller

Graduate Research Theses & Dissertations

The Female Athlete Triad (Triad) is the three interrelated conditions of low energy availability with or without disordered eating, menstrual irregularity or amenorrhea, and osteoporosis, and is a health concern that affects active women of all ages who participate in physical activity. Although associations have been found between the individual components of the Triad, research is still limited on all Triad components occurring simultaneously in athletes. In addition, research on the college-age female population is currently limited. The purpose of this study was to examine Triad risk factors in the college-age female athlete population compared to the non-athlete population, specifically …

Probiotic Bifidobacterium Strains And Galactooligosaccharides Improve Intestinal Barrier Function In Obese Adults But Show No Synergism When Used Together As Synbiotics, Janina A. Krumbeck, Heather E. Rasmussen, Robert W. Hutkins, Jennifer L. Clarke, Krista Shawron, Ali Keshavarzian, Jens Walter

Department of Food Science and Technology: Faculty Publications

Background: One way to improve both the ecological performance and functionality of probiotic bacteria is by combining them with a prebiotic in the form of a synbiotic. However, the degree to which such synbiotic formulations improve probiotic strain functionality in humans has not been tested systematically. Our goal was to use a randomized, double-blind, placebo-controlled, parallel-arm clinical trial in obese humans to compare the ecological and physiological impact of the prebiotic galactooligosaccharides (GOS) and the probiotic strains Bifidobacterium adolescentis IVS-1 (autochthonous and selected via in vivo selection) and Bifidobacterium lactis BB-12 (commercial probiotic allochthonous to the human gut) when used …

St. John’S Wort Regulates Proliferation And Apoptosis In Mcf-7 Human Breast Cancer Cells By Inhibiting Ampk/Mtor And Activating The Mitochondrial Pathway, Mi-Kyoung You, Hwa-Jin Kim, Ji Hyun Kook, Hyeon-A Kim

Department of Nutrition and Health Sciences: Faculty Publications

St. John’s Wort (SJW) has been used as an estrogen agonist in the systems affected by menopause. Also, hypericin, a bioactive compound of SJW, has been used as a photosensitizer in photodynamic therapy. In the present study, we investigate the anti-proliferative and pro-apoptotic effects of SJWto demonstrate the chemo-preventive effect in human breast cancer cells. MCF-7 cellswere culturedwith DMSO or various concentrations of SJWethanol extract (SJWE). Cell viability, proliferation, apoptosis, the expression of proteins involved in cell growth and apoptosis, and caspase-3/7 activity were examined. SJWE dose-dependently suppressed cell growth and induced apoptosis ofMCF-7 cells. Mechanistically, SJWE enhanced the phosphorylation …

Health Disparities Score Composite Of Youth And Parent Dyads From An Obesity Prevention Intervention: Icook 4-H, Melissa D. Olfert, Makenzie L. Barr, Rebecca L. Hagedorn, Lisa Franzen-Castle, Sarah E. Colby, Kendra K. Kattelmann, Adrienne A. White

Department of Nutrition and Health Sciences: Faculty Publications

iCook 4-H is a lifestyle intervention to improve diet, physical activity and mealtime behavior. Control and treatment dyads (adult primary meal preparer and a 9–10-year-old youth) completed surveys at baseline and 4, 12, and 24 months. A Health Disparity (HD) score composite was developed utilizing a series of 12 questions (maximum score = 12 with a higher score indicating a more severe health disparity). Questions came from the USDA short form U.S. Household Food Security Survey (5), participation in food assistance programs (1), food behavior (2), level of adult education completed (1), marital status (1), and race (1 adult and …

Milk Exosomes Are Bioavailable And Distinct Microrna Cargos Have Unique Tissue Distribution Patterns, Sonia Manca, Bijaya Upadhyaya, Ezra Mutai, Amy T. Desaulniers, Rebecca A. Cederberg, Brett R. White, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs, proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be obtained from dietary sources such as the inter-species transfer of exosomes and RNAs in bovine milk to humans. Here, we assessed the bioavailability and distribution of exosomes and their microRNA cargos from bovine, porcine and murine milk within and across species boundaries. Milk exosomes labeled with fluorophores or fluorescent fusion proteins accumulated in liver, spleen and brain following suckling, oral gavage and intravenous administration in …

The Contributions Of Arterial Cross‑Sectional Area And Time‑Averaged Flow Velocity To Arterial Blood Flow, Ethan C. Hill, Terry J. Housh, Cory M. Smith, Josh L. Keller, Richard J. Schmidt, Glen O. Johnson

Department of Nutrition and Health Sciences: Faculty Publications

Background: Ultrasound has been used for noninvasive assessments of endothelial function in both clinical and athletic settings and to identify changes in muscle blood flow in response to exercise, nutritional supplementation, and occlusion. The purposes of the present study were to examine the reliability and relative contributions of arterial cross‑sectional area and time‑averaged flow velocity to predict muscle blood flow as a result of fatiguing exercise in men and women. Methods: Eighteen healthy men and 18 healthy women performed 50 consecutive eccentric repetitions of the elbow flexors at 60% of their pretest eccentric peak torque at a velocity of 180° …

การพัฒนาอุปกรณ์วิเคราะห์ฐานกระดาษสำหรับหาปริมาณสารเพรดนิโซโลนและเดกซาเมทาโซนที่ปลอมปนในผลิตภัณฑ์สมุนไพรด้วยวิธีเคมีไฟฟ้า, วิศรุต พริ้มพราย

Chulalongkorn University Theses and Dissertations (Chula ETD)

การปลอมปนของสารสเตียรอยด์ชนิดเดกซาเมทาโซนและเพรดนิโซโลนในผลิตภัณฑ์สมุนไพรเป็นปัญหาสำคัญที่ก่อผลเสียร้ายแรงต่อสุขภาพของผู้ใช้ ในหลาย ๆ ประเทศทั่วโลก โดยเฉพาะอย่างยิ่งในประเทศกำลังพัฒนา งานวิจัยนี้ ประสบความสำเร็จในการพัฒนาอุปกรณ์สำหรับแยกและตรวจวัดปริมาณการปลอมปนของสารสเตียรอยด์ดังกล่าว โดยใช้อุปกรณ์ตรวจวิเคราะห์ฐานกระดาษและใช้หลักการทางเคมีไฟฟ้า (electrochemical paper-based analytical device หรือ ePAD) ซึ่งประกอบด้วยกระดาษ Whatman SG81 ตลับพลาสติกจากการพิมพ์สามมิติ และขั้วไฟฟ้าชนิด screen printed electrode โดยกระดาษ Whatman SG81 ใช้สำหรับแยกสารสเตียรอยด์ชนิดเดกซาเมทาโซนและเพรดนิโซโลน โดยใช้วัฏภาคเคลื่อนที่เป็นสารละลาย 60% ethyl acetate ใน cyclohexane ซึ่งผลการศึกษาพบว่าสามารถแยกสารสเตียรอยด์ดังกล่าวออกจากสิ่งเจือปนต่าง ๆ ได้ภายใน 7 นาที สารสเตียรอยด์ที่แยกออกจากกันบนกระดาษ นำมาวัดปริมาณด้วยเทคนิคเคมีไฟฟ้าชนิด differential pulse voltammetry โดยใช้ตลับพลาสติกจากการพิมพ์สามมิติที่ถูกออกแบบทำให้สารละลายอิเล็กโทรไลต์ถูกขังอยู่บนกระดาษ ทำให้สามารถตรวจวัดสัญญาณทางเคมีไฟฟ้าได้คงที่ ซึ่งอุปกรณ์ที่พัฒนาขึ้นสามารถตรวจวัดปริมาณปลอมปนของสารสเตียรอยด์ทั้งชนิดเดกซาเมทาโซนและ เพรดนิโซโลนได้ในช่วงความเข้มข้นระหว่าง 10 ถึง 500 µg/mL โดยมีค่าสัมประสิทธิ์สหสัมพันธ์เท่ากับ 0.988 และ 0.994 ตามลำดับ มีขีดจำกัดในการตรวจวิเคราะห์เชิงคุณภาพเท่ากับ 3.59 µg/mL และ 6.00 µg/mL ตามลำดับ และขีดจำกัดในการตรวจวิเคราะห์เชิงปริมาณมีค่าเท่ากับ 11.98 µg/mL และ 20.02 µg/mL ตามลำดับ การตรวจวัดปริมาณปลอมปนของสารสเตียรอยด์ทั้งสองชนิดในสิ่งตัวอย่างผลิตภัณฑ์สมุนไพรจริงด้วยวิธีที่พัฒนาขึ้นมีค่าสอดคล้องกับผลที่ตรวจด้วยวิธี HPLC และเป็นวิธีที่ใช้งานง่าย มีต้นทุนต่ำ รวดเร็ว และมีศักยภาพนำไปใช้ตรวจหาสิ่งตัวอย่างผลิตภัณฑ์สมุนไพรที่สงสัยว่ามีการปลอมปนของสารสเตียรอยด์ ในระดับภาคสนาม

The Effect Of Nac And Carnosine On Alzheimer’S Disease-Related In Vitro Model Through Rage-Age Signaling Pathway, Suphasarang Sirirattanakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Alzheimer’s disease (AD) is the most common dementia which found increasing with age. It involves neurodegeneration which leads to various abnormalities especially memory loss, inability to learn new things, lack of creativity, lack of decision making ability, lack of critical thinking, calculation inability, inability to live normal daily life, inability to recognize person, time and place, emotional disturbance, and difficulty to use language. Since AD has severe impact in various aspects on both the patients and their families, so we are interested to study the neurodegenerative mechanism when neuronal cells are under oxidative stress which will induce neuroinflammation through the …

Development Of Value Added Unripe Papaya Flour From Waste Product Of Fruit Industry, Waralee Joymak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Papaya fruit (Carica papaya L.) belonging to Caricaceae family is recognized as a good source of dietary fiber and antioxidants. The objective of this study was to develop the unripe papaya flour (UPF) from waste fruit product. The study was also investigated physicochemical, functional properties of UPF and its addition of pancake. First, the small pieces of unripe papaya were heated by hot air oven, then ground by using a high-speed universal grinder and sieved through a 100-mesh sieve. The particle size of UPF was 140.8±2.1 µm with randomly irregular shape. The hydration properties of UPF was higher than wheat …

Effect Of Bitter Gourd Extracts On The Mutagenicity Of 1-Aminopyrene Reacted With Nitrite Using Ames Test, Korkiat Panpasuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was conducted to investigate the mutagenic activity of raw and cooked bitter gourd (Momordica charantia) including raw fruit extract (RW), blanching water (BW), hot water extract from blanched fruit (HB), stir-fried fruit extract (SF), and stir-fried fruit (pre-squeezed with salt) extract (SS). In addition, the effects of extracts in modifying the mutagenic activity of mutagen freshly prepared by the reaction between 1-aminopyrene and sodium nitrite and the effects when adding each extract at the beginning of the same reaction using Ames test on Salmonella typhimurium strains TA98 and TA100 without enzymatic activation were also determined. The data for …

Antioxidant And Antimutagenic Activity Of Extracts From Pericarp And Seed Of Zanthoxylum Limonella Alston, Patamawan Wipoosanapan

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was conducted to investigate the antioxidant and antimutagenic activity of Zanthoxylum limonella seed extract and that of Z. limonella pericarp extract. The total phenolic contents and antioxidant activity assay including DPPH assay and FRAP assay were performed. The results showed that the antioxidant activity of pericarp extract was higher than that of the seed extract. The direct mutagenicity assay was determined, with and without nitrite treatment using the Ames test towards Salmonella typhimurium strains TA98 and TA100. The mutagenic modification assay was performed by measuring the interfering effect of the pericarp extract and the seed extract on the …

Carbohydrate Content Of The Medications For Epileptic Children Treated With Ketogenic Diet At King Chulalongkorn Memorial Hospital, Thanarat Sawangrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purposes of this study were to establish a database of the carbohydrate content of medications and investigate carbohydrate content of medications in epileptic children treated with ketogenic diet (KD) at King Chulalongkorn Memorial Hospital. One hundred sixty-nine KD order forms in 3 events (KD initiation, follow-up visit, and hospital re-admission) for epileptic children whose aged younger than 18 years old during 2009-2017 were selected. Clinical and nutritional data were obtained from medical records and KD order forms from the pediatric nutrition unit. The study showed that oral liquid dosage forms had the highest carbohydrate content in the formulations as …

The Effects Of Two Different Sports Drinks On Rpe And Finishing Speed Of An Endurance Run In Highly Trained Distance Runners, Matthew J. Feldhake

Masters Theses

The purpose of this study was to compare the effects of a protein-containing sport drink with a traditional non-protein sport drink has on ratings of perceived exertion (RPE) and finishing speed of an half marathon. Of the possible factors that would support including protein in a sport drink the primary one was its inhibitory effect on serotonin release in the brain. This could help attenuate perceived exertion, thus allowing individuals to compete at a higher level for longer durations (Davis, Alderson, & Welsh, 2000).

This study was conducted using nine members of the Eastern Illinois University Men's Cross Country team. …

Resolution Of The Nutritional Requirements And Metabolic Profile Of Clostridium Scindens Atcc 35704, A Major Bile Acid-Dehydroxylating Anaerobe In The Human Gut, Rachana Shrestha

Masters Theses

Bile acids (cholate and chenodeoxycholate) are synthesized from cholesterol in the human liver, and secreted in small intestine for food digestion. However, a portion of these primary bile acids is converted in the colon to toxic secondary bile acids, deoxycholate and lithocholate. Secondary bile acid formation is the result of 7α-dehydroxylating anaerobes, and one of the key players in this conversion is Clostridium scindens. Interestingly, little is known about the basic physiology and nutrition of C. scindens. Therefore, the goal of this research was to understand the nutritional requirement, and determine the 7α-dehydroxylation activity and end products from …

Investigating University Students' Cultural Competency In Relation To Time Spent Abroad, Elizabeth Baylee Edwards

Honors Theses

Background: The world is becoming increasingly interconnected through the globalization of economy, resources, and social interactions, creating an environment where individuals must be able to respect, understand, and work closely with people of different cultures. The purpose of this research was to investigate how traveling abroad affects university students' level of competency in five cultural dimensions. Methods: An electronic survey, designed to evaluate cultural competency, was distributed to 6,000 randomly selected undergraduate students in January, 2018. Descriptive statistics were used to demonstrate sample profiles. Exploratory factor analysis (EFA) was used to determine factors of competency dimensions for global mindedness. A …

Effects Of Point Of Purchase Marketing On Selection Of Vegetables In A University Greek House Foodservice, Shelton Wittenberg

Honors Theses

Weight gain is common for undergraduate college students because of factors such as body maturation, increased consumption of fast food, and less physical activity. Weight gain may continue after college if diet and exercise habits do not improve, so learning healthy habits during college can contribute to a healthy adulthood. Recent research has reported that weight gain is inversely related to fruit and vegetable consumption. Because a large portion of college students' diets come from on-campus dining options, fruit and vegetable intake may be lacking because many of these venues may not serve these items or serve them in a …

Beyond The Breakfast Club: The Influence Of Breakfast Type On Cognition, Jillian D. Saccogna

Senior Independent Study Theses

The glycemic index (“GI”) of a food refers to the magnitude with which the food elevates an individual’s blood glucose levels, and this value can be used to calculate the glycemic load (“GL”) of a specific portion of food. Some evidence suggests that blood glucose levels may play a key role in self-control. Emerging research suggests that consuming low GI or GL breakfasts may enhance memory performance and result in greater levels of positive affect compared to high GI or GL breakfasts. Participants in the present study were randomly assigned to consume either a low GI/GL breakfast or a high …

Independent And Interactive Associations Of Negative Affect, Restraint, And Impulsivity In Relation To Binge Eating Among Women, Tyler B. Mason, Kathryn E. Smith, Jason M. Lavender, Robin J. Lewis

Psychology Faculty Publications

There is growing recognition that impulsivity may serve as an underlying risk factor for binge eating. In addition, the association of impulsivity with binge eating may be moderated by other affective and cognitive risk factors. This study examined independent and interactive associations of negative affect, dietary restraint, and facets of impulsivity with binge eating. A diverse sample of 566 undergraduate women completed online questionnaires of study variables. Results revealed a three-way interaction of negative affect, dietary restraint, and attentional impulsivity in relation to binge eating. Women who were high on each of these three variables reported the greatest levels of …

Sports Nutrition Newsletters, Michelle Dilling

Williams Honors College, Honors Research Projects

The purpose of my project is to teach athletes that nutrition is important to their performance, to introduce them to new topics, and to separate fact from fiction by citing evidence-based research. Additionally, the purpose of my project is to design a template for this newsletter that can be used to continue publications.

Examining The Credentials Of Food Bloggers And The Online Environment Of Food Blogs, Jessica Coburn

Master's Theses and Doctoral Dissertations

This study evaluated characteristics of food blogs and food bloggers that potentially affect food choices. It was hypothesized that most food bloggers would not have a nutrition-related degree and food blog environments wouldn’t be supportive of health-conscious food choices. A cross-sectional study was conducted using a novel evaluation tool on 187 blogs, out of which 100 blogs met inclusion criteria. Because some blogs had multiple bloggers, two samples were investigated: 111 bloggers (n1 = 111) and 100 food blogs (n2 = 100). Data were gathered from a randomized list of blogs taken from americanfoodbloggers.com. Results showed that 6% of bloggers …

A Qualitative Study Of Families’ Experiences With Food Insecurity In Addis Ababa, Ethiopia, Elias Omer

Theses and Dissertations (Comprehensive)

Ethiopia has shown considerable progress in alleviating the decades-long food insecurity problem, but still, in the context of urban areas such as Addis Ababa families continue to struggle to make ends meet. The overall purpose of this research is to explore families’ lived experiences and coping mechanisms with food insecurity. Framed with the narrative-empowerment theoretical framework this ethnographic study outlines the findings of semi-structured interviews and focus group discussion of 35 adults and children and observational notes. Participants were able to tell their perception, causes, and impacts of food insecurity in their families. They outlined the daily strategies they employ …

A Nutritional Analysis Of Food Menus Offered At Local Older Adult Assisted Living Facilities, Chloe R. Schmir

Honors Theses and Capstones

Nutrition is important in all stages of life, especially in the later years. The purpose of this study was to analyze the food offerings from local assisted living facilities on a nutritional basis. Upon collecting weekly food menus, they were evaluated based on the 2015-2020 Dietary Guidelines for Americans (DGAs) in the domains of food groups, food variety, and excess fats, sugars, and salt. Not a single facility met the DGA requirements completely in food groups or food variety. The food groups facilities were most deficient in were fruits and dairy. Furthermore, each of the menus had items rich in …

Vulnerable, Single And Living In Poverty: Women’S Challenges To Accessing Food In The Australian Capital Territory, Tanya Lawlis, Amanda Devine, Penney Upton

Research outputs 2014 to 2021

Objective: To explore challenges to food access faced by vulnerable women living in the Australian Capital Territory and surrounds.

Method: Qualitative study comprising semi‐structured interviews supplemented with quantitative demographic data.

Results:Forty‐one women, mean age of 43 years, living in government and community housing who had an income of

Conclusion: Access to safe, nutritious and healthy food is difficult for women living in poverty. Acknowledgement of challenges that contribute to women’s food insecurity by all stakeholders is essential to address the problem and build sustainable actions and solutions.

Implications for public health: Collaboration from all stakeholders within our food system …

Snac_Oshc: Exploring A Multifaceted Approach To Develop Outside Of School Hours Care As A Health Promoting Setting, Karen Forde

Theses : Honours

Background: Outside of school hours care (OSHC) services are underutilised as health promoting settings, yet are well positioned to influence health behaviours. OSHC Professionals are ideally placed to become positive influencers in this setting, although may require training to confidently perform this role.

Aim: This research trialed a multifaceted intervention strategy to increase OSHC Professional’s confidence and competencies, to support a health promoting OSHC environment with a nutrition and PA activity focus.

Design and Methods: This exploratory study adopted a mixed methods approach. The three-pronged, multifaceted intervention included: a workshop, a closed Facebook group, and a website. 19 OSHC Professionals, …

Waste Not, Want Not: Using Source-Separated Urine To Cultivate Maize In The Southern Highlands, Tanzania, Lucy Hatfield

Dissertations, Master's Theses and Master's Reports

In Sub-Saharan African countries, soil fertility is low due to unsustainable agricultural practices and little to no access to chemical fertilizer. Poor yields have resulted in many of these countries struggling to produce enough food to feed their growing populations. Human urine has been used as an effective, low-cost alternative to chemical fertilizers in greenhouse and plot trials on a variety of vegetables, but its effects on elemental grain composition in cereal crops are largely unknown. Here we tested whether diluted human urine applied as a fertilizer can increase maize crop growth, yield and nutritional content on small family-owned plots. …

Role Of 3-Hydroxy Fatty Acid-Induced Hepatic Lipotoxicity In Acute Fatty Liver Of Pregnancy, Sathish Kumar Natarajan, Jamal A. Ibdah

Department of Nutrition and Health Sciences: Faculty Publications

Acute fatty liver of pregnancy (AFLP), a catastrophic illness for both the mother and the unborn offspring, develops in the last trimester of pregnancy with significant maternal and perinatal mortality. AFLP is also recognized as an obstetric and medical emergency. Maternal AFLP is highly associated with a fetal homozygous mutation (1528G>C) in the gene that encodes for mitochondrial long-chain hydroxy acyl-CoA dehydrogenase (LCHAD). The mutation in LCHAD results in the accumulation of 3-hydroxy fatty acids, such as 3-hydroxy myristic acid, 3-hydroxy palmitic acid and 3-hydroxy dicarboxylic acid in the placenta, which are then shunted to the maternal circulation leading …

Gardening Experience Is Associated With Increased Fruit And Vegetable Intake Among First-Year College Students: A Cross-Sectional Examination, Jennifer Loso, Daniel Staub, Sarah E. Colby, Melissa D. Olfert, Kendra Kattelmann, Melissa Vilaro, James Colee, Wenjun Zhou, Lisa Franzen-Castle, Anne E. Matthews

Department of Nutrition and Health Sciences: Faculty Publications

Background Gardening interventions have been shown to increase fruit and vegetable (F/V) intake among school-aged children. It is unknown whether these effects persist into later adolescence or adulthood, and little is known about whether gardening in later adolescence is related to F/V intake. Objective To identify the relationship between both childhood and recent (within the past 12 months) gardening experiences and current F/V intake among college students. Design/participants A cross-sectional evaluation of 1,121 college freshmen with suboptimal F/V consumption from eight US universities. Main outcome measures Participants completed the National Cancer Institute Fruit and Vegetable Screener and questions about gardening …

Inhibitory Effects Of Toll-Like Receptor 4, Nlrp3 Inflammasome, And Interleukin-1Β On White Adipocyte Browning, Meshail Okla, Walid Zaher, Musaad Alfayez, Soonkyu Chung

Department of Nutrition and Health Sciences: Faculty Publications

Adipose tissue expansion is accompanied by infiltration and accumulation of pro-inflammatory macrophages, which links obesity to pathologic conditions such as type 2 diabetes. However, little is known regarding the role of pro-inflammatory adipose tissue remodeling in the thermogenic activation of brown/beige fat. Here, we investigated the effect of pattern recognition receptors (PRR) activation in macrophages, especially the toll-like receptor 4 (TLR4) and Nod-like receptor 3 (NLRP3), on white adipocyte browning. We report that TLR4 activation by lipopolysaccharide repressed white adipocyte browning in response to β3-adrenergic receptor activation and caused ROS production and mitochondrial dysfunction, while genetic deletion of TLR4 protected …