Open Access. Powered by Scholars. Published by Universities.®
Other Neuroscience and Neurobiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (2)
- Molecular and Cellular Neuroscience (2)
- Amino Acids, Peptides, and Proteins (1)
- Analytical, Diagnostic and Therapeutic Techniques and Equipment (1)
- Biochemistry, Biophysics, and Structural Biology (1)
-
- Biology (1)
- Cancer Biology (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Cellular and Molecular Physiology (1)
- Chemicals and Drugs (1)
- Disease Modeling (1)
- Diseases (1)
- Genetics and Genomics (1)
- Molecular Biology (1)
- Nervous System Diseases (1)
- Other Cell and Developmental Biology (1)
- Other Genetics and Genomics (1)
- Physiology (1)
- Psychology (1)
- Social Psychology (1)
- Social and Behavioral Sciences (1)
- Therapeutics (1)
- Translational Medical Research (1)
- Keyword
-
- BDNF (2)
- Artificial Insertions (1)
- Axonal transport (1)
- Basigin (1)
- Brain Derived Neurotrophic Factor (1)
-
- Brain derived neurotrophic factor (1)
- Chlorotoxin (1)
- Cre-Lox Recombination (1)
- Dynactin (1)
- EMMPRIN (1)
- FNIRS (1)
- GBM (1)
- Genetic Models (1)
- Glioblastoma Treatment (1)
- JIP3 (1)
- Knockout Model (1)
- MPFC (1)
- Motor neuron (1)
- Nature (1)
- Neuromuscular disease (1)
- Open Field Test (1)
- Prepulse Inhibition (1)
- Sciatic nerve ligation (1)
- Scorpion (1)
- Self-diminishment (1)
- Skeletal muscle (1)
- Small Gene Inserts (1)
- Theranostic (1)
- TrkB (1)
- Unexpected Phenotype (1)
Articles 1 - 4 of 4
Full-Text Articles in Other Neuroscience and Neurobiology
Situation Mouse All Floxed Up: Exploring Phenotypic Abnormalities In Bdnf Floxed Mice, Marissa A. Burkman
Situation Mouse All Floxed Up: Exploring Phenotypic Abnormalities In Bdnf Floxed Mice, Marissa A. Burkman
All NMU Master's Theses
Animal research is a contentious topic in both the scientific and general communities. It is essential that our animal models accurately and predictably depict intended phenotypes, necessitating careful colony monitoring and maintenance. Volunteer animal staff in the Ottem Laboratory became concerned when mice with LoxP sites flanking the BDNF gene depicted anxiety-like behaviors such as aggression, difficulty handling, and increased agitation. Though many studies have noted behavioral and phenotypic abnormalities related to large gene inserts, few have noted abnormalities with small gene inserts such as the 34 bp LoxP site. Brandt (2018) performed a three-stage behavioral protocol on these mice …
Medial Prefrontal Cortex Fnirs Activity While Viewing Nature And Urban Scenes: The Search For Neurological Evidence Of Nature's Transcendent Self-Diminishment Effect, Haylee V. Snyder
All NMU Master's Theses
Prior research suggests that exposure to nature increases prosociality. One of the theories as to why this happens is that nature can elicit self-diminishment which leads to the positive experience of paying less attention to oneself. To better understand the neural processes behind this, this study used functional near-infrared spectroscopy (fNIRS) to measure activity in the medial prefrontal cortex (mPFC) which is related to the self-concept. Participants were shown 12 images divided into four blocks separated by image types. Six were entirely natural scenes (three pleasant and three unpleasant), and six were entirely urban scenes (three pleasant and three unpleasant). …
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
All NMU Master's Theses
Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent antitumor activity, blood-brain barrier permeability, and capability for tumor-specific drug deliverance and intraoperative visualization (termed theranostic) were of focus. Confocal microscopy was employed to characterize in vitro specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of extracellular matrix metalloproteinase inducer (EMMPRIN; Basigin) isoform …
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
All NMU Master's Theses
Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor …