Other Neuroscience and Neurobiology Commons^™

Beyond Ssris: Omega-3 Fatty Acids And The Neurobiology Of Impulsivity In Borderline Personality Disorder, Sujean Doo

Scripps Senior Theses

Impulsivity is a central and clinically significant dimension of Borderline Personality Disorder (BPD), and is strongly associated with self-harm, aggression, and suicide risk. Despite its prognostic importance, pharmacologic management of impulsivity in BPD remains inconsistent. Selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed; however, randomized controlled trials demonstrate limited efficacy for impulsive-aggression, and some patients experience a paradoxical behavioral activation. Meta-analytic and systematic reviews further suggest that mood stabilizers and second-generation antipsychotics may outperform antidepressants, yet no specific medication is indicated to target impulsive behavioral dyscontrol.

This thesis synthesizes findings from systematic reviews, randomized trials, and neuroimaging research to evaluate …

A Spectroscopy Study Of The Brain: Exploring Sex Differences In Healthy Older Adults, Angela Gushue

CMC Senior Theses

Cognitive decline and aging-related disorders, such as Alzheimer’s, disproportionately affect patients based on sex, but the mechanisms underlying these skewed effects are unknown. This proton magnetic resonance spectroscopy (H-MRS) study seeks to understand if sex disparities in aging exist in neurometabolite concentrations of older adult brains. Sixty-seven participants, ranging from 60 to 85 years of age, underwent the Montreal Cognitive Assessment (MoCA) and H-MRS of the brain. Concentrations of myo-inositol, total creatine, total NAA, and total choline were calculated in the dorsal posterior cingulate cortex, left hippocampal cortex, left medial temporal gyrus, left primary sensorimotor cortex, and right dorsolateral prefrontal …

The Standing Of Anger: Insights From The Debate(S) On Constructed Emotion, Andrew Holzer

CMC Senior Theses

In her book, Anger and Forgiveness: Resentment, Generosity, Justice, Martha Nussbaum argues that anger is inherently flawed because it fundamentally contains the desire for payback. To support her argument, she posits specific metaphysical claims about the nature of emotions like anger. This thesis is an extended critique of her metaphysical foundation from the perspective of empirical research in the neuroscience of emotion. The first reason to dispute this picture is descriptive; this view of anger is based on an outdated version of cognitive appraisal theory, which sees emotions as triggered directly by static moments of cognitive appraisal. The second …

Making The Invisible Visible: Mapping Chronic Pain Through Art, Caroline Young

Scripps Senior Theses

This Studio Art thesis explores how I use my art practice as a chronic pain healing process. It draws on the fundamentals of the neuroscience behind pain and the implications of this science for people with chronic pain. People with chronic pain often turn to alternative healing techniques in their search for relief; my own alternative healing approach comes from my art practice of “pain mapping."

The artistic healing process that I have developed takes inspiration from chronically ill artists such as Frida Kahlo and Anna Cowley Ford. The artistic mapping of my pain that I have developed primarily uses …

From Rainman To Rainmaker: A Presentation Of Jim’S Journey And Rapidly Advancing Technologies: Integrating Proven Behavioral Therapies With Emergent Measurement And Testing Advances Will Result In Transformational Progress In Autistic Individuals, Richard Zajac

CMC Senior Theses

The autism treatment status quo was reviewed and accompanied by a narrative contextualizing past and present progress with my younger brother Jim’s journey with the condition, sharing proposed next steps for bettering the current state of affairs in the space. The impetus for this piece was to share in the lessons of Jim’s life thus far and the revelations of those who have supported him, as well as to determine ways to create more impactful, lasting change in the limited window of early intervention therapy whilst empowering individuals on the spectrum to optimize for their skills and talents rather than …

Neural Responses To Vibration During Wobble Board Balancing, Michael Nguyentat

CMC Senior Theses

Falling, an epidemic most prevalently seen in the elderly population, accounts for the majority of injury-related cases seen by emergency departments across the United States. Unfortunately, with no large-scale institutionalization of a solution, the problem is only expected to exacerbate as our planet’s population approaches the 7 billion mark. In the wake of the recent surge of falls among the elderly, Japan has implemented a program to include unicycling in the physical education curriculum for elementary schools across the country. The goal for this program is to encourage children to establish strong fundamental balancing skills, which could potentially alleviate the …