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Modulation Of Gabaa Receptor By Neurosteroids And Protein Kinases In Health And Disease, Jaymin Jeong

Electronic Thesis and Dissertation Repository

γ-aminobutyric acid type A receptors (GABA_A receptors) underlie the majority of inhibitory synaptic transmission in the brain. Modulation of GABAergic activity occurs in development and normal physiological functioning of the brain, and changes to GABAergic function has been implicated in numerous neurological disorders including epilepsy. Neurosteroids, metabolites of steroid hormones, and kinases are known to modulate GABA_A receptor mediated currents in health and disease. This thesis aims to investigate the effects of kinases and neurosteroids on modulating GABA_A receptor-mediated currents in cortical pyramidal cells and their effects on the piriform cortex (PCtx) circuit in naïve rats and …