Molecular and Cellular Neuroscience Commons^™

Phosphorylation Of Tau Protein At Thr175 Is A Toxic Event Associated With Neurodegeneration, Alexander Moszczynski

Electronic Thesis and Dissertation Repository

Aberrant phosphorylation and pathological deposition of the microtubule associated protein tau (tau protein) is associated with toxicity and cellular death in a number of neurodegenerative diseases (tauopathies). Specific phosphorylation sites are of interest in the processes leading to tau protein toxicity. One site of interest on tau protein is Thr¹⁷⁵ (pThr¹⁷⁵), which has been identified in diseased brain tissue from individuals with amyotrophic lateral sclerosis with cognitive impairment (ALSci) and Alzheimer’s disease. In vitro, pseudophosphorylation at this residue has been shown to induce the formation of pathological tau fibrils and, apoptotic cell death.

In my thesis, …