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Molecular and Cellular Neuroscience Commons™
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Hypothalamic-pituitary-adrenal axis; corticotrophin releasing hormone neurons; prostaglandin E2; GABA; restraint stress; inflammation
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Full-Text Articles in Molecular and Cellular Neuroscience
Psychological Stress Modulates Synaptic Mechanisms For Prostaglandin E2-Mediated Hpa Axis Activation, Meagan Wiederman
Psychological Stress Modulates Synaptic Mechanisms For Prostaglandin E2-Mediated Hpa Axis Activation, Meagan Wiederman
Electronic Thesis and Dissertation Repository
Immune-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis elevates glucocorticoids, anti-inflammatory hormones, promoting the effective resolution of inflammation. Psychological stress can modulate this anti-inflammatory mechanism, but the mechanisms underlying this modulation remain largely unknown. The immune-induced HPA axis activation is, in large part, mediated by prostaglandin E2 (PGE2), an inflammatory mediator. In the brain, PGE2 attenuates GABAergic synaptic transmission onto corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) that act as the apex of the HPA axis. The removal of GABA-mediated inhibition (i.e. disinhibition) excites CRH neurons and, consequently, activates the HPA axis. …