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Molecular and Cellular Neuroscience Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Molecular and Cellular Neuroscience
Investigating The Effects Of Excitotoxic Stimuli On The Suprachiasmatic Nucleus, Rachel A. Brandes
Investigating The Effects Of Excitotoxic Stimuli On The Suprachiasmatic Nucleus, Rachel A. Brandes
Chancellor’s Honors Program Projects
No abstract provided.
The Effects Of A Ketone Body On Synaptic Transmission, Alexandra Elizabeth Stanback
The Effects Of A Ketone Body On Synaptic Transmission, Alexandra Elizabeth Stanback
Theses and Dissertations--Biology
The ketogenic diet is commonly used to control epilepsy, especially in cases when medications cannot. The diet typically consists of high fat, low carb, and adequate protein and produces a metabolite called acetoacetate. Seizure activity is characterized by glutamate excitotoxicity and therefore glutamate regulation is a point of research for control of these disorders. Acetoacetate is heavily implicated as the primary molecule responsible for decreasing glutamate in the synapse; it is believed that acetoacetate interferes with the transport of glutamate into the synaptic vesicles. The effects on synaptic transmission at glutamatergic synapses was studied in relation to the ketogenic diet …