Open Access. Powered by Scholars. Published by Universities.®
Molecular and Cellular Neuroscience Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 8 of 8
Full-Text Articles in Molecular and Cellular Neuroscience
Characterizing The Rogfp2-Orp1 Fluorescent Biosensor For Detecting Oxidative Stress In Mammalian Cells, Sara A. Doan, Stevie Norcross, Mathew Tantama
Characterizing The Rogfp2-Orp1 Fluorescent Biosensor For Detecting Oxidative Stress In Mammalian Cells, Sara A. Doan, Stevie Norcross, Mathew Tantama
The Summer Undergraduate Research Fellowship (SURF) Symposium
Parkinson’s disease is a neurodegenerative disease involving the death of neurons in the substantia nigra and loss of the neurotransmitter, dopamine. The disease leads to progressive loss of motor control. Exact causes and mechanisms by which Parkinson’s disease proceeds are unknown, however, previous experiments determine oxidative stress in mitochondria as a factor that results in cell death. Strategies have been implemented to generate fluorescent biosensors to monitor reactive oxygen species (ROS) concentrations while simultaneously measuring the spatiotemporal distribution and correlation between the ROS, cellular function and organelle. Orp1, an enzyme found in yeast, is a sensitive oxidizing species and when …
Analysis Of Mitochondrial Turnover In Neuromuscular Junctions Of Parkin Mutants, Kenny Nguyen, Hyun Sung, Peter J. Hollenbeck
Analysis Of Mitochondrial Turnover In Neuromuscular Junctions Of Parkin Mutants, Kenny Nguyen, Hyun Sung, Peter J. Hollenbeck
The Summer Undergraduate Research Fellowship (SURF) Symposium
The accumulation of dysfunctional or damaged mitochondria in neurons has been linked to the pathogenesis of many neurodegenerative diseases, such as Parkinson’s disease. It has been proposed that proteins PINK1 and Parkin regulate mitochondrial quality control by selectively targeting depolarized mitochondria for autophagic degradation, a process known as mitophagy. Though previously analyzed in the cell bodies and axons of neurons, the role of the PINK1/Parkin pathway in the synapse is unclear, and it is not known whether mitochondrial turnover occurs in the neuromuscular junctions (NMJs). To study this, intact Drosophila nervous systems were analyzed in vivo by performing gentle dissections …
A Screen To Identify Saga-Activated Genes That Are Required For Proper Photoreceptor Axon Targeting In Drosophila Melanogaster, Kaelan J. Brennan, Vikki M. Weake, Jingqun Q. Ma
A Screen To Identify Saga-Activated Genes That Are Required For Proper Photoreceptor Axon Targeting In Drosophila Melanogaster, Kaelan J. Brennan, Vikki M. Weake, Jingqun Q. Ma
The Summer Undergraduate Research Fellowship (SURF) Symposium
The inherited human genetic disease spinocerebellar ataxia type 7 (SCA7) is characterized by progressive neurodegeneration and visual impairment that ultimately leads to blindness. SCA7 results from a mutation in the human ATXN7 gene that causes an expansion of polyglutamine tracts in this gene’s corresponding protein. Human ATXN7 protein serves as a component of the deubiquitylase (DUB) module of the large, multi-subunit complex Spt-Ada-Gcn acetyltransferase, or SAGA. SAGA is a transcriptional coactivator and histone modifier that functions to deubiquitylate histone H2B and allow for transcription of SAGA-mediated genes to occur. In Drosophila, mutations in SAGA DUB’s Nonstop and sgf11 components …
Coding Of Social Signals By Glutamatergic And Gabaergic Neurons In The Social Neural Network, Megan Moore
Coding Of Social Signals By Glutamatergic And Gabaergic Neurons In The Social Neural Network, Megan Moore
Georgia State Undergraduate Research Conference
No abstract provided.
Characterizing Orphan Gpcrs In Molluscan Neurons Through Bioinformatics, Preetham Ganupuru
Characterizing Orphan Gpcrs In Molluscan Neurons Through Bioinformatics, Preetham Ganupuru
Georgia State Undergraduate Research Conference
No abstract provided.
Does The Crayfish Tail Fan Sense Chemicals, Semira Adella, Imon Allen, Tyler Flot
Does The Crayfish Tail Fan Sense Chemicals, Semira Adella, Imon Allen, Tyler Flot
Georgia State Undergraduate Research Conference
No abstract provided.
Establishing A Synaptoneurosome Preparation To Investigate Memory Formation Of A Meal, Alexa Faulkner, Amy P. Ross
Establishing A Synaptoneurosome Preparation To Investigate Memory Formation Of A Meal, Alexa Faulkner, Amy P. Ross
Georgia State Undergraduate Research Conference
No abstract provided.
Circadian Rhythmic Localization Of Tpa And Pai-1 In The Scn 2.2 Cell Culture May Provide Evidence For Determining The Mechanism Of Gating Photic Phase Shifts, Grayson T Hunley
Circadian Rhythmic Localization Of Tpa And Pai-1 In The Scn 2.2 Cell Culture May Provide Evidence For Determining The Mechanism Of Gating Photic Phase Shifts, Grayson T Hunley
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Mammalian circadian rhythms are controlled by a central pacemaker located in the suprachiasmatic nucleus (SCN) of the brain. The SCN exhibits endogenous rhythms in neuronal activity and entrains to external stimuli, particularly light. Interestingly, phase shifts in response to light only occur at night and the mechanisms gating phase shifting are not well characterized. Our lab demonstrated that the extracellular protease, tissue-type plasminogen activator (tPA) and its inhibitor, plasminogen activator inhibitor (PAI-1), help gate phase shifting. Total tPA and PAI-1 expression are rhythmic in mouse SCN. These proteins mediate different functions depending on their exact subcellular localization. Therefore, knowing where …