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Full-Text Articles in Molecular and Cellular Neuroscience
Characterization Of The Transporter Protein Sodium-Potassium Adenosine Triphosphatase In The Myelin Membrane, Dara E C Schaefer
Characterization Of The Transporter Protein Sodium-Potassium Adenosine Triphosphatase In The Myelin Membrane, Dara E C Schaefer
Theses and Dissertations (Comprehensive)
Sodium-potassium adenosine triphosphatase (Na+/K+-ATPase) is an integral membrane protein with known involvement in the maintenance of resting membrane potentials, nutrient uptake, cellular signal transduction, and cell-cell adhesion. The functional enzyme contains a catalytic alpha subunit and a glycosylated beta subunit, of which three isoforms of each are known to exist in the central nervous system (CNS). Altered expression and/or activity of Na+/K+-ATPase subunit isoforms has been previously implicated in the pathophysiology of several neurological disorders. This study characterized Na+/K+-ATPase expression and distribution in the myelin membrane, identified its …