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Full-Text Articles in Molecular and Cellular Neuroscience
Comparison Of Nickel And Cobalt Induced Hypoxic Cell Models Using Cell Proliferation Assay, Melissa Delcasale
Comparison Of Nickel And Cobalt Induced Hypoxic Cell Models Using Cell Proliferation Assay, Melissa Delcasale
Seton Hall University Dissertations and Theses (ETDs)
Hypoxia is an imbalance in oxygen delivery and oxygen consumption, ultimately affecting cell survival. Low levels of oxygen diminish adenosine triphosphate synthesis resulting from a decline in oxidative phosphorylation in the mitochondria, therefore inducing apoptosis and cell death. To create a hypoxia mimicked environment, we used hypoxia mimetic compounds cobalt and nickel to treat human neuroblastoma (NMB) cells. Using hypoxic mimic human neuronal cell models, we examined and compared the effects of compound-induced hypoxia on NMB cell proliferation. The cells were treated with 100mM and 300mM concentrations of each compound at 24- and 48-hour intervals. To investigate cell proliferation, the …
Investigating The Role Of Tp53inp1 And Tp53inp2 In Neuronal Autophagy And Mitophagy, Vidhyasree Shyam
Investigating The Role Of Tp53inp1 And Tp53inp2 In Neuronal Autophagy And Mitophagy, Vidhyasree Shyam
Electronic Thesis and Dissertation Repository
Autophagy is highly conserved cellular process that functions in ensuring the turnover of proteins and organelles in a number of different cell types. Mitophagy is a selective form of autophagy which serves to target and rid the cell of damaged or superfluous mitochondria. The process is central to preventing the accumulation of defective mitochondria and is particularly important in neurons, which rely exclusively on mitochondria to sustain their immense metabolic needs. Dysregulation of autophagy is believed to contribute to the neurodegeneration seen in such disorders as Parkinson’s disease and cerebral ischemia. However, further understanding of the role of neuronal autophagy …