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Molecular and Cellular Neuroscience Commons™
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Articles 1 - 5 of 5
Full-Text Articles in Molecular and Cellular Neuroscience
The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen Kw Wong
The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen Kw Wong
Undergraduate Student Research Internships Conference
Clinical and preclinical studies indicate prenatal cannabis exposure (PCE) pathologically affects fetal brain development and may increase vulnerability to neuropsychiatric disorders, including schizophrenia and mood/anxiety disorders. In review research from our lab suggests that fetal exposure to Δ9-THC sex-selectively impairs mesocorticolimbic (MCL) circuit function. However, there is a distinct lack of focus on PCE models on the BLA. The BLA plays a central role within the MCL where it directly interacts with the VTA, PFC and HIPP. Importantly, our model exhibits significant VTA hyperdopaminergic activity, and sex-specific alterations to PFC/HIPP glutamate firing, alongside region- and sex-specific changes in dopamine (DA), …
Estimating Glutamate Transporter Surface Density In Mouse Hippocampal Astrocytes, Anca R. Radulescu, Annalisa Scimemi
Estimating Glutamate Transporter Surface Density In Mouse Hippocampal Astrocytes, Anca R. Radulescu, Annalisa Scimemi
Biology and Medicine Through Mathematics Conference
No abstract provided.
Morphine-Induced Hyperactivity Is Attenuated By Intra-Accumbens Administration Of The Highly-Selective Dopamine D3 Receptor Antagonist Vk4-40, Mansi Patel, Desta M. Pulley, Daniel Manvich
Morphine-Induced Hyperactivity Is Attenuated By Intra-Accumbens Administration Of The Highly-Selective Dopamine D3 Receptor Antagonist Vk4-40, Mansi Patel, Desta M. Pulley, Daniel Manvich
Rowan-Virtua Research Day
Opioids exert their abuse-related effects by enhancing dopamine (DA) neurotransmission within the brain’s mesolimbic reward system, a neural projection involving DA neurons in the ventral tegmental area (VTA) that project to medium spiny neurons within the nucleus accumbens (NAc). Mu (MOR) are expressed by several populations of GABAergic neurons that tonically inhibit VTA DA neurons. By inhibiting these GABAergic neurons in a MOR-dependent manner, opioids indirectly enhance DA neurotransmission via disinhibition of DAergic neurons. Accumulating evidence indicates that selective pharmacological antagonism of the dopamine D3 receptor (D3R) attenuates the abuse-related effects of several opioids, but the neurobiological mechanisms mediating this …
Trkb Activity Alters Voluntary Alcohol Consumption In Nondependent Mice, Alfred Amendolara
Trkb Activity Alters Voluntary Alcohol Consumption In Nondependent Mice, Alfred Amendolara
Annual Research Symposium
No abstract provided.
Novel Methodology For The Investigation Of Dmrt3a Interneurons In Larval Zebrafish, Alfred Amendolara
Novel Methodology For The Investigation Of Dmrt3a Interneurons In Larval Zebrafish, Alfred Amendolara
Annual Research Symposium
No abstract provided.