Open Access. Powered by Scholars. Published by Universities.®
Molecular and Cellular Neuroscience Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Alzheimer's (1)
- Amyloid Beta (1)
- Astrogliosis (1)
- CNS (1)
- Calcium (1)
-
- Central Nervous (1)
- Cord (1)
- Dementia (1)
- Exitotoxicity (1)
- Free Radical (1)
- Glial (1)
- Injury (1)
- Nervous (1)
- Neurodegeneration (1)
- Neurofibrillary tangles (1)
- Primary injury (1)
- Reactive oxygen species (1)
- Research (1)
- Secondary injury (1)
- Spinal (1)
- Spinal Column (1)
- Spinal Cord (1)
- Spine (1)
- Tau (1)
- Therapies (1)
- Therapy (1)
- Trauma (1)
- Treatment (1)
Articles 1 - 2 of 2
Full-Text Articles in Molecular and Cellular Neuroscience
Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast
Alzheimer's And Amyloid Beta: Amyloidogenicity And Tauopathy Via Dyshomeostatic Interactions Of Amyloid Beta, Jordan Tillinghast
Senior Honors Theses
This paper reviews functions of Amyloid-β (Aβ) in healthy individuals compared to the consequences of aberrant Aβ in Alzheimer’s disease (AD). As extraneuronal Aβ accumulation and plaque formation are characteristics of AD, it is reasonable to infer a pivotal role for Aβ in AD pathogenesis. Establishing progress of the disease as well as the mechanism of neurodegeneration from AD have proven difficult (Selkoe, 1994). This thesis provides evidence suggesting the pathogenesis of AD is due to dysfunctional neuronal processes involving Aβ’s synaptic malfunction, abnormal interaction with tau, and disruption of neuronal homeostasis. Significant evidence demonstrates that AD symptoms are partially …
Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin
Senior Honors Theses
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is …