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Dopaminergic Innervation Of The Subventricular Zone In The Murine Brain, Linda Beth Drozdowicz
Dopaminergic Innervation Of The Subventricular Zone In The Murine Brain, Linda Beth Drozdowicz
Honors Scholar Theses
The subventricular zone (SVZ) is one of two areas in the brain that, in a healthy mouse, continually generate neurons throughout adulthood. While it was previously thought that only the A9 neurons of the substantia nigra sent dopaminergic afferents to the SVZ, recent studies suggest that the A10 neurons of the ventral tegmental area may innervate this area. This project has aimed to discover which, if either, model is correct.
Examination of the Aphakia (AK) mouse was used to determine the role of distinct midbrain regions in SVZ regulation. Additionally, intraperitoneal injections of the chemical MPTP were used to deduce …