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Molecular and Cellular Neuroscience Commons™
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Full-Text Articles in Molecular and Cellular Neuroscience
Step Regulation Of Seizure Thresholds In The Hippocampus, Janice R. Naegele
Step Regulation Of Seizure Thresholds In The Hippocampus, Janice R. Naegele
Janice R Naegele
Purpose: To investigate whether striatal enriched protein tyrosine phosphatase (STEP) influences ictogenesis. Methods: STEP knockout mice were compared to wild-type (WT) mice in pilocarpine-induced seizures. Hippocampal slices were also prepared from these two mouse populations, allowing the examination of ictal-like stimulation in these slices using calcium imaging and electrophysiologic recordings. Key Findings: To examine seizure thresholds, increasing doses of pilocarpine were administered to adult mice and seizures were scored behaviorally. Significantly fewer STEP knockout mice developed seizures that progressed to the stage of status epilepticus compared to WT mice. To examine potential differences in neural circuits that might account for …
Migration Of Transplanted Neural Stem Cells In Experimental Models Of Neurodegenerative Diseases., Janice Naegele
Migration Of Transplanted Neural Stem Cells In Experimental Models Of Neurodegenerative Diseases., Janice Naegele
Janice R Naegele
No abstract provided.
Tangled Roots: Digging Deeper Into Astrocyte Or Interneuron Dysfunction In Temporal Lobe Epilepsy., Janice R. Naegele
Tangled Roots: Digging Deeper Into Astrocyte Or Interneuron Dysfunction In Temporal Lobe Epilepsy., Janice R. Naegele
Janice R Naegele
No abstract provided.