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Molecular and Cellular Neuroscience Commons™
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- Keyword
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- Neurodegeneration (2)
- Alzheimer's Disease (1)
- As those identified in primary tauopathies (e.g. P301L and G389R) (1)
- BDNF (1)
- Both enhanced vesicular release of tau in the extracellular space (1)
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- Caenorhabditis elegans (C. elegans) (1)
- Due to a process called phase separation. My Thesis tested the hypothesis that tau mutations (1)
- Excitotoxicity (1)
- Gene regulation (1)
- Glutamate receptor (1)
- In both HEK293T and SHSY-5Y cells compared to wild type. However (1)
- Insulin; Insulin‐like growth factor (IGF) (1)
- Into either HEK293T (1)
- It has recently been well accepted that tau is also an intrinsically disordered protein that tends to form membraneless organelles called coacervates (1)
- Might impair the phase separation properties of the protein and impact its pathological role in cells. I first tested the effect of single amino acid substitutions in vitro (1)
- Neuroprotection (1)
- Odorant receptors (1)
- Olfaction (1)
- One third is characterized by the presence of genetic mutations leading to the synthesis of tau proteins with single amino acid substitutions at specific locations and affecting protein function. While most of the initial studies have emphasize the functional role of tau as modulator of the axonal cytoskeleton (1)
- Or in SHSY-5Y neuroblastoma cells (1)
- PAT1 (1)
- Phase Separation (1)
- RNA-binding protein (1)
- SecretionTau is a protein expressed exclusively in glia and neurons in the central nervous system and implicated in several neurogenerative diseases called “tauopathies”. Among all the tauopathies (1)
- Signaling; FoxO (1)
- Synaptogenesis (1)
- Tamalin/GRAS-1 (1)
- Tau (1)
- The expression of tau mutants did not affect cell viability in response to oxidative stress. While the relationship between the biophysical properties of tau and its function in cells remain to be elucidated (1)
- This study suggest potential mechanisms by which specific mutations of tau may induce its release in the extracellular space and suggest a potential role in spreading of the pathology. (1)
Articles 1 - 4 of 4
Full-Text Articles in Molecular and Cellular Neuroscience
Characterization Of Pathological Tau Mutants, Charles J. Mcdonald
Characterization Of Pathological Tau Mutants, Charles J. Mcdonald
Dissertations, Theses, and Capstone Projects
Tau is a protein expressed exclusively in glia and neurons in the central nervous system and implicated in several neurogenerative diseases called “tauopathies”. Among all the tauopathies, one third is characterized by the presence of genetic mutations leading to the synthesis of tau proteins with single amino acid substitutions at specific locations and affecting protein function. While most of the initial studies have emphasize the functional role of tau as modulator of the axonal cytoskeleton, it has recently been well accepted that tau is also an intrinsically disordered protein that tends to form membraneless organelles called coacervates, due to a …
Employing High Probability Gene Choice Elements To Understand Singular Odorant Receptor Expression, Raena Mina
Employing High Probability Gene Choice Elements To Understand Singular Odorant Receptor Expression, Raena Mina
Dissertations, Theses, and Capstone Projects
The ability to detect odorous chemicals in the environment is the oldest of the senses necessary for survival, from escaping danger, finding mates, to locating food. It is said that humans can identify and discriminate up to a trillion different odor mixtures. For chemoreception to have such a high discriminatory power, would require a diverse population of cells dedicated for odor detection. These detector cells are the olfactory sensory neurons (OSNs), which express odorant receptors (ORs) that bind to chemical odors in the environment. In order to increase specificity and sensitivity, an essential property in olfaction is for each OSN …
Tamalin/Gras-1 Connects Glutamate Receptor Activity To The Insulin/Igf Signaling Cascade To Regulate Neuroprotection In A Nematode Model Of Excitotoxicity, Ayesha Chowdhury
Tamalin/Gras-1 Connects Glutamate Receptor Activity To The Insulin/Igf Signaling Cascade To Regulate Neuroprotection In A Nematode Model Of Excitotoxicity, Ayesha Chowdhury
Dissertations, Theses, and Capstone Projects
Brain ischemia is a major cause of debilitation and death in the United States. Excitotoxicity, a condition that arises from the accumulation of glutamate (Glu) in the synapse that leads to overactivation of Glu receptors (GluRs), is the major mechanism of neuronal damage in brain ischemia / stroke. Although it is commonly acknowledged that over activation of GluRs leads to neurodegeneration, it has been recently shown that even during excitotoxicity Glu has a concurrent important role in regulating neuroprotection. GluR-activated transcription factors seem to mediate this neuroprotection, but it remains unclear which signaling cascades and transcription factors are regulated by …
A Novel Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Synapse Development, Hao Wu
A Novel Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Synapse Development, Hao Wu
Dissertations, Theses, and Capstone Projects
Cytoskeleton based active transport with motor proteins is essential for mRNA localization and local protein translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased screen for interaction between mRNA binding proteins (RBP) and motor proteins, we identified protein interacting with APP tail 1 (PAT1) as a potential direct adapter between the β-actin mRNA Zipcode-binding protein 1 (ZBP1) and Kinesin-1 motor complex.
Mouse PAT1 is similar to the Kinesin Light Chain (KLC) in amino acid sequence and binds directly to KLC. High-resolution images from structured illumination microscopy (SIM) indicates that synaptic stimulation …