Open Access. Powered by Scholars. Published by Universities.®
Molecular and Cellular Neuroscience Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Addiction (1)
- Adolescence (1)
- Anxiety Disorders (1)
- Autophagy (1)
- BDNF (1)
-
- Calcium ions (1)
- Depressive Disorders (1)
- Dopamine (1)
- Drosophila melanogaster (1)
- Estrogen (1)
- GABA (1)
- Glutamate (1)
- Ion channels (1)
- Myelination (1)
- Neural development (1)
- Neurodevelopment (1)
- Nicotine (1)
- Nucleus Accumbens (1)
- Oligodendrocyte (1)
- Prefrontal Cortex (1)
- RNAseq (1)
- SERCA (1)
- Sensitivity (1)
- Sex Differences (1)
- Spinal cord injury (1)
- Translatome (1)
- Tumor model (1)
- Ventral Tegmental Area (1)
Articles 1 - 3 of 3
Full-Text Articles in Molecular and Cellular Neuroscience
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Sex Differences In Mood And Anxiety-Related Outcomes In Response To Adolescent Nicotine Exposure, Tsun Hay Jason Ng
Electronic Thesis and Dissertation Repository
Nicotine dependence is causally linked to increased risk of mood/anxiety disorders in later life. Females are reported to experience a higher prevalence of anxiety/depressive disorders and challenges in smoking cessation therapies, suggesting a potential sex-specific response to nicotine exposure and mood/anxiety disorder risk. However, pre-clinical evidence of sex-specific responses to adolescent nicotine exposure is unclear. Thus, to determine any sex differences in anxiety/depressive-related outcomes, adolescent male and female Sprague Dawley rats received nicotine (0.4 mg/kg; 3x daily) or saline injections for 10 consecutive days, followed by behavioural testing, in-vivo electrophysiology and Western Blot analyses. Our results revealed that adolescent nicotine …
Novel Insights Into Oligodendrocyte Biology From Developmental Myelination Studies In Autophagy Deficient Mice And Analysis Of Oligodendrocyte Translatome Response To Contusive Spinal Cord Injury., Michael David Forston
Novel Insights Into Oligodendrocyte Biology From Developmental Myelination Studies In Autophagy Deficient Mice And Analysis Of Oligodendrocyte Translatome Response To Contusive Spinal Cord Injury., Michael David Forston
Electronic Theses and Dissertations
Loss of myelin causes severe neurological disorders and functional deficits in white matter injuries (WMI) such as traumatic spinal cord injury (SCI). This dissertation is focused on autophagy in OL development and the OL translatome after SCI. Chapter I describes the history of myelin, OL development, and their involvement in neurodegenerative diseases and SCI. The proteostasis network, in particular autophagy, and its contributions to white matter pathology is discussed. It concludes examining advantages and disadvantages of unbiased omics tools, like RiboTag, to study transcriptional/translational landscapes after SCI. Chapter II focuses on autophagy in OPC/OL differentiation, survival, and proper myelination in …
The Role Of Serca In Neural Development And Brain Tumors, Hannah M. Christman
The Role Of Serca In Neural Development And Brain Tumors, Hannah M. Christman
Undergraduate Theses, Professional Papers, and Capstone Artifacts
Ion channels are essential for neural function, playing a variety of necessary cellular roles including excitability, maintaining ion gradients, and volume control. While the role of ion channels in neurons is well-defined, much less is known about excitability in neural progenitor cells. Recently it has emerged that these neural precursors may be affected by channelopathies, indicating a critical role of ion channels in neural development. Using the model system Drosophila melanogaster (fruit fly), I investigated the role of the ion channel SERCA (sarco/endoplasmic reticulum Ca2+ATPase). SERCA is a vital calcium ion pump located on the wall of the endoplasmic reticulum, …