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Molecular and Cellular Neuroscience Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Cataract (2)
- Cholesterol (2)
- Cholesterol biosynthesis (2)
- Development (2)
- Eye lens (2)
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- Hippocampus (2)
- Myelin (2)
- Oligodendrocyte (2)
- Protein aggregation (2)
- Qki (2)
- Srebp2 (2)
- ALL (1)
- Acute lymphoblastic leukemia (1)
- Agalychnis callidryas (1)
- Aging (1)
- Anaxyrus americanus (1)
- Anuran (1)
- Astrocyte (1)
- Brain morphology (1)
- CCN (1)
- Cerebral hemisphere (1)
- Chemobrain (1)
- Cognitive deficits (1)
- Computerized cognitive training (1)
- Corpus callosum (1)
- Cortex (1)
- Cystine (1)
- DCCN (1)
- Developmental Cortical Malformation (1)
- Drug-resistant Epilepsy (1)
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Articles 1 - 12 of 12
Full-Text Articles in Molecular and Cellular Neuroscience
Qki-Mediated Cholesterol Biosynthesis In Eye Lens And Myelin Of The Central Nervous System, Seula Shin, Seula Shin
Qki-Mediated Cholesterol Biosynthesis In Eye Lens And Myelin Of The Central Nervous System, Seula Shin, Seula Shin
Dissertations & Theses (Open Access)
Cells obtain cholesterol in two ways, de novo biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion of cholesterol. Brain is the most cholesterol-rich organ, which accounts for 23% of total cholesterol. Genetic mutations of cholesterol biosynthesis enzymes in humans and animal models present cataracts and hypomyelinating disorders linked to neurological impairment. Yet, it remains unclear how gene expression of cholesterol biosynthesis is regulated in lens and brain. Therefore, studying cholesterol biosynthesis in both tissues …
Qki-Mediated Cholesterol Biosynthesis In Eye Lens And Myelin Of The Central Nervous System, Seula Shin, Seula Shin
Qki-Mediated Cholesterol Biosynthesis In Eye Lens And Myelin Of The Central Nervous System, Seula Shin, Seula Shin
Dissertations & Theses (Open Access)
Cells obtain cholesterol in two ways, de novo biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion of cholesterol. Brain is the most cholesterol-rich organ, which accounts for 23% of total cholesterol. Genetic mutations of cholesterol biosynthesis enzymes in humans and animal models present cataracts and hypomyelinating disorders linked to neurological impairment. Yet, it remains unclear how gene expression of cholesterol biosynthesis is regulated in lens and brain. Therefore, studying cholesterol biosynthesis in both tissues …
Methylmercury Cytotoxicity On Developing Neuronal Lineages And Differences In Susceptibility Based On Media Type, Madeline Henley
Methylmercury Cytotoxicity On Developing Neuronal Lineages And Differences In Susceptibility Based On Media Type, Madeline Henley
The Journal of Purdue Undergraduate Research
No abstract provided.
Characterization Of Neuronal Differentiation And Activity In Human-Induced Pluripotent Neural Stem Cells, Allison Biddinger
Characterization Of Neuronal Differentiation And Activity In Human-Induced Pluripotent Neural Stem Cells, Allison Biddinger
The Journal of Purdue Undergraduate Research
No abstract provided.
Preliminary Evidence Of The Role Of Medial Prefrontal Cortex In Self-Enhancement: A Transcranial Magnetic Stimulation Study, Birgitta Taylor-Lillquist, Vivek Kanpa, Maya Crawford, Mehdi El Filali, Julia Oakes, Alex Jonasz, Amanda Disney, Julian Keenan
Preliminary Evidence Of The Role Of Medial Prefrontal Cortex In Self-Enhancement: A Transcranial Magnetic Stimulation Study, Birgitta Taylor-Lillquist, Vivek Kanpa, Maya Crawford, Mehdi El Filali, Julia Oakes, Alex Jonasz, Amanda Disney, Julian Keenan
Department of Biology Faculty Scholarship and Creative Works
Humans employ a number of strategies to improve their position in their given social hierarchy. Overclaiming involves presenting oneself as having more knowledge than one actually possesses, and it is typically invoked to increase one’s social standing. If increased expectations to possess knowledge is a perceived social pressure, such expectations should increase bouts of overclaiming. As the medial prefrontal cortex (MPFC) is sensitive to social pressure and disruption of the MPFC leads to decreases in overclaiming, we predicted that transcranial magnetic stimulation (TMS) applied to the MPFC would reduce overclaiming and the effects would be enhanced in the presence of …
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice, Gabrielle Emily Samulewicz
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice, Gabrielle Emily Samulewicz
Biology - All Scholarship
Astrocytes play a vital role in orchestrating the precise brain wiring that occurs during development and are essential for maintaining homeostasis into adulthood. The cystine/glutamate antiporter, system xc-, in the central nervous system is especially abundant in astrocytes and itself is known to contribute importantly to the basal extracellular glutamate concentration as well as the intracellular and extracellular glutathione levels, either of which, if perturbed, could alter brain development and/or contribute to degeneration. Thus, to determine whether loss of astrocyte system xc- might alter brain morphology, I studied a conditional astrocyte system xc- knockout mouse (AcKO). Tissue was harvested from …
Neurocognitive Risk Factors And Current Intervention Strategies For Survivors Of Pediatric Acute Lymphoblastic Leukemia, Abigail Taber
Neurocognitive Risk Factors And Current Intervention Strategies For Survivors Of Pediatric Acute Lymphoblastic Leukemia, Abigail Taber
Senior Honors Theses
The improved survival rate for pediatric cancer patients is one of the greatest triumphs of recent medicine, but the late effects faced by these survivors have been uncovered through this new population of survivors. Many survivors of pediatric acute lymphoblastic leukemia (ALL) experience cognitive deficits in areas such as attention, memory, processing speed, and academic achievement following cancer treatment. Recent research has pointed to chemotherapeutic agents, host risk factors, and genetic predispositions as perpetrators of these deficits, although other factors are also under investigation. Consequently, the search for appropriate interventions for the amelioration of these deficits has dominated the literature …
Developing Tadpoles Exhibit Metabolic And Organ Size Plasticity In Competitive Rearing Environments, Emma Kimberly
Developing Tadpoles Exhibit Metabolic And Organ Size Plasticity In Competitive Rearing Environments, Emma Kimberly
Undergraduate Honors Thesis Projects
Abstract
Plasticity is the ability of an organism to respond to environmental variation by expressing different phenotypes. In Red-eyed treefrog tadpoles, Agalychnis callidryas, competitive environments induce long guts and short tails. Despite having a larger gut, tadpoles reared with competition do not increase intake when food becomes available. Pilot data suggest that this is because they have lower metabolic rates. The ability to maintain a larger gut with a depressed metabolic rate is confusing because guts are energetically expensive, and suggests that another energetic trade-off is taking place. The purpose of this study was to investigate the effect of …
Effect Of Reduced Neurogenesis On Microglial Activation, Amelia Smith
Effect Of Reduced Neurogenesis On Microglial Activation, Amelia Smith
Honors Scholars Collaborative Projects
The geriatric population of America has grown exponentially in the past century. Health degradations and expensive medical care are characteristic of this population with many of these costs due to age-related cognitive decline. It is essential to completely understand the mechanisms of normal and abnormal aging in the search for treatments for cognitive decline. A reduction of neurogenesis is a common factor in aging, but this reduction is even more drastic in individuals experiencing cognitive decline. It is unclear what effect reduced neurogenesis has on the extracellular environment, including glial cells. In particular, changes in microglial activation could be related …
Tissue-Specific Regulation Of Pnmt By Intron Retention During Neural Development, Meeti Mehta
Tissue-Specific Regulation Of Pnmt By Intron Retention During Neural Development, Meeti Mehta
Digital Repository: Showcase of Undergraduate Research Excellence
No abstract provided.
Focal Augmentation Of Somatostatin Interneuron Function And Subsequent Circuit Effects In Developmentally Malformed, Epileptogenic Cortex, Nicole Ekanem
Theses and Dissertations
Drug-resistant epilepsy (DRE) is a common clinical sequela of developmental cortical malformations such as polymicrogyria. Unfortunately, much remains unknown about the aberrant GABA-mediated circuit alterations that underlie DRE's onset and persistence in this context. To address this knowledge gap, we utilized the transcranial freeze lesion model in optogenetic mice lines (Somatostatin (SST)-Cre or Parvalbumin (PV)-Cre x floxed channelrhodopsin-2) to dissect features of the SST, PV, and pyramidal neuron microcircuit that are potentially associated with DRE. Investigations took place within developmental microgyria’s known pathological substrate, the adjoined and epileptogenic paramicrogyral region (PMR). As well, microcircuit relationships within the previously unexplored range …
Characterizing The Requirements For The Matricellular Protein, Dccn, In Nervous System Function, Elizabeth L. Catudio Garrett
Characterizing The Requirements For The Matricellular Protein, Dccn, In Nervous System Function, Elizabeth L. Catudio Garrett
Graduate Student Theses, Dissertations, & Professional Papers
The brain is organized as a complex network of specialized neurons that communicate via a combination of electrical and chemical signals. Our brains function to generate movement, control organ function, or direct complex behaviors; all of which requires the ability to regulate the flow of communication between circuits and networks. Work in this thesis addresses two areas of neuron communication: first, how does the release of more than one neurotransmitter from a single neuron impact behavior, and second, are matricellular proteins (MCPs) key contributors to synaptic transmission and neuron function? The conserved CCN family of MCPs have a …