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Full-Text Articles in Molecular and Cellular Neuroscience
Voltage-Gated K+ Channels And Hiv-1-Induced Neural Injury: Implications For Pathogenesis Of Hiv-1-Associated Neurocognitive Disorders, Han Liu
Theses & Dissertations
Human immunodeficiency virus-1 (HIV-1)-associated neurocognitive disorder (HAND) is a subcortical disease involving neuronal loss and myelin damage. Myelin is deposited by oligodendrocytes through a complex process including oligodendrocyte progenitor cell (OPC) proliferation and maturation. Oligodendrocytes/OPCs are susceptible to viral proteins such as Tat and that myelin damage is associated with oligodendrocyte number decrease. It has been shown that activation of voltage-gated K+ (KV) channels mediates apoptosis in various cell types. KV1.3 is the most predominant KV channel expressed in OPCs/oligodendrocytes and potentially involved in OPC developmental regulation. We studied the involvement of KV …