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Full-Text Articles in Molecular and Cellular Neuroscience
Hyaluronan At The Brain-Environment Interface, Donald M. Thevalingam
Hyaluronan At The Brain-Environment Interface, Donald M. Thevalingam
Dissertations, Theses, and Capstone Projects
Hyaluronan (HA; Hyaluronic Acid), a primary scaffolding component of the brain extracellular matrix, serves as an integral structural component to the brain extracellular space (ECS). The fossorial African naked mole-rat (Heterocephalus glaber; NM-R), a mammal which lives in a low-oxygen environment and is capable of tolerating hypoxia and hypercapnia, has been shown to synthesize and sustain a unique high-molecular-mass variant of hyaluronan macromolecule (HMM-HA). This body of work highlights HA’s role in mediating the interplay between brain ECM composition, ECS structure, and cell viability.
Here we employ the NM-R as a unique animal model to observe the role of the …