Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (5)
- Behavioral Neurobiology (3)
- Cell and Developmental Biology (3)
- Cognitive Neuroscience (3)
- Developmental Biology (3)
-
- Medical Sciences (3)
- Molecular and Cellular Neuroscience (2)
- Neurosciences (2)
- Psychology (2)
- Social and Behavioral Sciences (2)
- Artificial Intelligence and Robotics (1)
- Arts and Humanities (1)
- Cell Biology (1)
- Cognition and Perception (1)
- Cognitive Psychology (1)
- Computational Neuroscience (1)
- Computer Sciences (1)
- Developmental Psychology (1)
- Discourse and Text Linguistics (1)
- Education (1)
- Educational Sociology (1)
- First and Second Language Acquisition (1)
- Laboratory and Basic Science Research (1)
- Linguistics (1)
- Medical Biophysics (1)
- Medical Neurobiology (1)
- Medical Physiology (1)
- Institution
- Keyword
-
- Autism (2)
- Differentiation (2)
- AUTISM (1)
- Age Factors (1)
- Angelman syndrome (1)
-
- Animals (1)
- Applied psychology (1)
- Axon (1)
- Brain Mapping (1)
- Cadherin (1)
- Catenin (1)
- Clinical psychology (1)
- Cognitive behavioral therapy (1)
- Cyclic peptides (1)
- Dendrites (1)
- Desmosome (1)
- Disability (1)
- EEG (1)
- Education (1)
- Educational psychology (1)
- Educational psychology and counseling (1)
- Ets (1)
- Etv1 (1)
- Hippocampus (1)
- Hyperthermia (1)
- Hyperthermia, Induced (1)
- IQ (1)
- Induced (1)
- Intellectual & developmental disabilities (1)
- Isoform (1)
- Publication
- Publication Type
- File Type
Articles 1 - 11 of 11
Full-Text Articles in Developmental Neuroscience
Developmental And Molecular Functions Of Plakophilin-3, William A. Munoz
Developmental And Molecular Functions Of Plakophilin-3, William A. Munoz
Dissertations & Theses (Open Access)
Plakophilin-3, the less studied member of the plakophilin-catenin subfamily, and the larger catenin family, binds directly to desmosomal cadherin cytoplasmic domains and enhances desmosome formation and stability. In mammals, plakophilin-3 is expressed at the highest levels in desmosome-enriched tissues such as epithelia, with the knock-out in mice producing corresponding reductions in ectodermal integrity. In tissue, cellular and intracellular contexts where plakophilin-3 is not at the desmosomal plaque, little is known about its functions in the cytoplasm or nucleus, where it also localizes.
My work employed embryos of the amphibian, Xenopus laevis, to examine plakophilin-3’s developmental roles. I first evaluated …
Social Compass Curriculum: Three Descriptive Case Studies Of Social Skills Outcomes For Students With Autism, Louanne E. Boyd, Deborah M. Ward
Social Compass Curriculum: Three Descriptive Case Studies Of Social Skills Outcomes For Students With Autism, Louanne E. Boyd, Deborah M. Ward
Engineering Faculty Articles and Research
The Social Compass Curriculum (SCC) was investigated for its effectiveness in improving core social skills in three descriptive case studies of students with autism. Treatment fidelity of the SCC was also measured in the school setting. The Social Responsiveness Scale and the Autism Social Skills Profile were completed by parents to measure pre- and postintervention social skills for three students aged 8 to 11 years who participated in the present multisite pilot study. Fidelity of implementation data were collected via a checklist during observations for three educators who implemented the intervention. Results indicate that the SCC improved core social deficits …
Behavioral, Biochemical, And Molecular Indices Of Stress Are Enhanced In Female Versus Male Rats Experiencing Nicotine Withdrawal, Laura O'Dell
Laura Elena O'Dell
Stress is a major factor that promotes tobacco use and relapse during withdrawal. Although women are more vulnerable to tobacco use than men, the manner in which stress contributes to tobacco use in women versus men is unclear.Thus, the goal of this study was to compare behavioral and biological indices of stress in male and female rats during nicotine withdrawal. Since the effects of nicotine withdrawal are age-dependent, this study also included adolescent rats. An initial study was conducted to provide comparable nicotine doses across age and sex during nicotine exposure and withdrawal. Rats received sham surgery or an osmotic …
Magnetic Resonance Imaging Of Brain Tissue Abnormalities: Transverse Relaxation Time In Autism And Tourette Syndrome And Development Of A Novel Whole-Brain Myelin Mapping Technique, Yann Gagnon
Electronic Thesis and Dissertation Repository
The transverse relaxation time (T2) is a fundamental parameter of magnetic resonance imaging sensitive to tissue microstructure and water content, thus offering a non-invasive approach to evaluate abnormalities of brain tissue in-vivo. Prevailing hypotheses of two childhood psychiatric disorders were tested using quantitative T2 imaging and automated region of interest (ROI) analyses. In autism, the under-connectivity theory, which proposes aberrant connectivity within white matter (WM) was assessed, finding T2 to be eleveted in the frontal and parietal lobes, while dividing whole brain data into neurodevelopmentally relevant WM ROIs found increased T2 in bridging and radiate WM. In Tourette syndrome, tissue …
Loss Of Dendritic Inhibition In The Hippocampus After Repeated Early-Life Hyperthermic Seizures In Rats., Richard Boyce, L Stan Leung
Loss Of Dendritic Inhibition In The Hippocampus After Repeated Early-Life Hyperthermic Seizures In Rats., Richard Boyce, L Stan Leung
Physiology and Pharmacology Publications
Seizures are relatively common in children and are a risk factor for subsequent temporal lobe epilepsy. To investigate whether early-life seizures themselves are detrimental to the proper function of the adult brain, we studied whether dendritic excitation and inhibition in the hippocampus of adult rats were altered after hyperthermia-induced seizures in immature rats. In particular, we hypothesized that apical dendritic inhibition in hippocampal CA1 pyramidal cells would be disrupted following hyperthermia-induced seizures in early life. Seizure rats were given three hyperthermia-induced seizures per day for three days from postnatal day (PND) 13 to 15; control rats were handled similarly but …
Impairment Of Trkb-Psd-95 Signaling In Angelman Syndrome, Cong Cao, Mengia S. Rioult-Pedotti, Paolo Migani, Crystal J. Yu, Rakesh Tiwari, Keykavous Parang, Mark R. Spaller, Dennis J. Goebel, John Marshall
Impairment Of Trkb-Psd-95 Signaling In Angelman Syndrome, Cong Cao, Mengia S. Rioult-Pedotti, Paolo Migani, Crystal J. Yu, Rakesh Tiwari, Keykavous Parang, Mark R. Spaller, Dennis J. Goebel, John Marshall
Pharmacy Faculty Articles and Research
Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal expression of the maternally inherited Ube3A ubiquitin protein ligase, required for the proteasomal degradation of proteins implicated in synaptic plasticity, such as the activity-regulated cytoskeletal-associated protein (Arc/Arg3.1). Mice deficient in maternal Ube3A express elevated levels of Arc in response to synaptic activity, which coincides with severely impaired long-term potentiation (LTP) in the hippocampus and deficits in learning behaviors. In this study, we sought to test whether elevated levels of Arc interfere with brain-derived neurotrophic factor (BDNF) …
Pleiotropic And Isoform-Specific Functions For Pitx2 In Superior Colliculus And Hypothalamic Neuronal Development, Mindy Waite
Pleiotropic And Isoform-Specific Functions For Pitx2 In Superior Colliculus And Hypothalamic Neuronal Development, Mindy Waite
Mindy Waite
Retinal Ganglion Cell Differentiation And Transplantation, Jonathan Hertz
Retinal Ganglion Cell Differentiation And Transplantation, Jonathan Hertz
Jonathan Hertz
Adult central nervous system (CNS) neurons fail to regenerate following injury, and there is no repair or replacement of cells lost after injury or in neurodegenerative diseases. There is much interest in transplanting stem cell-derived neurons into the injured nervous system and enhancing the differentiation of donor cells into mature, integrated and functional neurons. Little is known, however, about what signals control the differentiation and integration of neurons, either during development or in the adult. Generating appropriate types of donor neurons from stem cells has been challenging because the signals that regulate neural subtype-specific fates are largely unknown. Therefore, it …
Brain Function Differences In Language Processing In Children And Adults With Autism, Diane L. Williams, Vladimir L. Cherkassky, Robert A. Mason, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just
Brain Function Differences In Language Processing In Children And Adults With Autism, Diane L. Williams, Vladimir L. Cherkassky, Robert A. Mason, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just
Marcel Adam Just
No abstract provided.
Brain Activity Of Normal And Low Iq Children: The Neural Efficiency Hypothesi, Fabio T. Rocha, Armando F. Rocha, Sueli Angeloti
Brain Activity Of Normal And Low Iq Children: The Neural Efficiency Hypothesi, Fabio T. Rocha, Armando F. Rocha, Sueli Angeloti
Armando F Rocha
The neural efficiency hypothesis (NEH) of intelligence claims that subjects performing a complex task may well use a limited number of brain circuits and/or fewer neurons while poor performers use more circuits and/or neurons, some of which are inessential or detrimental to task performance. The present paper studies the EEG activity associated with reading and arithmetic calculation by normal and mental retarded children. Correlation analysis of the electrical activity recorded by 10/20 electrode system was used to calculate the amount of information allocated by individuals to solve these tasks. Multiple regression analyses showed that IQ linearly correlates with the amount …
Substituting The Senses, Mirko Farina, Julian Kiverstein, Andy Clark
Substituting The Senses, Mirko Farina, Julian Kiverstein, Andy Clark
Mirko Farina
Sensory substitution devices are a type of sensory prosthesis that (typically) convert visual stimuli transduced by a camera into tactile or auditory stimulation. They are designed to be used by people with impaired vision so that they can recover some of the functions normally subserved by vision. In this chapter we will consider what philosophers might learn about the nature of the senses from the neuroscience of sensory substitution. We will show how sensory substitution devices work by exploiting the cross-modal plasticity of sensory cortex: the ability of sensory cortex to pick up some types of information about the external …